Clinical and Experimental Pediatrics

Review Article

Allergy

Eosinophil-derived neurotoxin levels can predict allergic disease development and atopic march in children

Zak Callaway, Chang-Keun Kim

Clin Exp Pediatr. 2025;68(6):398-405. Published online February 3, 2025

· Allergic march occurs in a subset of children, beginning with atopic dermatitis and progressing to food allergies, allergic rhinitis, and/or asthma. Its early diagnosis is important to slowing its progression.
· Eosinophil-derived neurotoxin (EDN), an excellent biomarker of eosinophil activity, is often elevated in allergic diseases.
· EDN levels have been used to predict allergic disease development and diagnose, treat, and monitor allergic diseases.

DOI: https://doi.org/10.3345/cep.2024.01382

Montelukast use over the past 20 years: monitoring of its effects and safety issues

Yong Ju Lee, Chang-Keun Kim

Clin Exp Pediatr. 2020;63(10):376-381. Published online February 5, 2020

Web of Science 20 Crossref 18

Although the efficacy of montelukast is inferior to that of ICS, both physicians and parents prefer montelukast to ICSs.
EDN may be a useful biomarker for the treatment and monitoring of preschool children with asthma.
The US FDA requires boxed warning about serious neuropsychiatric events of montelukast, therefore, physicians should consider the benefits and risks of montelukast before prescribing it.

DOI: https://doi.org/10.3345/cep.2019.00325

Eosinophil-derived neurotoxin: a novel biomarker for diagnosis and monitoring of asthma

Chang-Keun Kim

Clin Exp Pediatr. 2013;56(1):8-12. Published online January 29, 2013

Crossref 40

Asthma is associated with increased levels of eosinophils in tissues, body fluids, and bone marrow. Elevated levels of eosinophil-derived neurotoxin (EDN) and eosinophil cationic protein (ECP) have been noted in asthma patients. Higher levels of EDN and ECP are also associated with exacerbated asthmatic conditions. Thus, EDN, along with ECP, may aid the diagnosis and monitoring of asthma. Several groups...

DOI: https://doi.org/10.3345/kjp.2013.56.1.8

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