Clinical and Experimental Pediatrics

Review Article

Cardiology

Application of CRISPR-Cas9 gene editing for congenital heart disease

Heeyoung Seok, Rui Deng, Douglas B. Cowan, Da-Zhi Wang

Clin Exp Pediatr. 2021;64(6):269-279. Published online March 2, 2021

Clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR-Cas9) system has made a big step in the genome editing which still requires technical developments for the efficient applications in the many fields including congenital heart diseases (CHDs), closely related to the genomic abnormality. In this review, we tried to cover the most updated researches of CRISPR-Cas9 in the CHDs to understand the current technologies, eventually becoming therapeutic bases for the CHD patients.

DOI: https://doi.org/10.3345/cep.2020.02096

Respiratory syncytial virus infection in children with congenital heart disease: global data and interim results of Korean RSV-CHD survey

Jo Won Jung

Clin Exp Pediatr. 2011;54(5):192-196. Published online May 31, 2011

Crossref 18

Respiratory syncytial virus (RSV) is a main cause of hospitalization for bronchiolitis and pneumonia in infants worldwide. Children with hemodynamically significant congenital heart disease (HS-CHD), as well as premature infants are at high risk for severe RSV diseases. Mortality rates for CHD patients hospitalized with RSV have been reported as about 24 times higher compared with those without RSV infection....

DOI: https://doi.org/10.3345/kjp.2011.54.5.192

Right-sided heart failure in congenital heart diseases

Jo Won Jung

Clin Exp Pediatr. 2007;50(11):1055-1060. Published online November 15, 2007

Right-sided heart failure is a major problem among patients with congenital heart diseases, due to the prevalence of congenital heart defects and the association of pulmonary hypertension. More attention is focused on the structure of the right heart particularly in association with congenital heart defects and chronic lung disease. The right ventricle (RV) may support the pulmonary circulation, and sometimes...

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