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Original Article
Development of a Screening Kit for Early Diagnosis and Prevention of Wilson`s Disease
Sihoun Hahn, Soo-Young Lee, Young-Ju Jang, Soon-Nam Kim, Ha-Cheol Shin, Sun-Young Park, Joo-Hyoung Kang, Eun-Sun You
Clin Exp Pediatr. 2001;44(12):1374-1380.   Published online December 15, 2001
Purpose : Wilson`s disease is an autosomal recessive disorder characterized by copper accumulation in the liver, brain, and other organs due to defected copper metabolism. The incidence of Wilson`s disease is approximately one in 30,000 population in the world, more common than phenylketonuria in Korea. The early diagnosis or presymptomatic diagnosis of Wilson`s disease is critical in order for them...
HDL Cholesterol, Copper, Ceruloplasmin, Zinc, Iron Values of the Blood in Newborn
Kyeong Sang Kim, Chun Hang Lee, Hong Jin Lee, Won Ill Park, Kyung Ja Lee, Tae Hyon Yoon, Won Chan Tae
Clin Exp Pediatr. 1992;35(8):1096-1101.   Published online August 15, 1992
HDL choleaterol, copper, ceruloplasmin, zinc, and iron values of the blood of 85 newborns delivered at hallym University hospital from September, 1989 to February, 1991 were analysed. The results were as follows: 1) The mean value of HDL cholesterol in 50 normal newborns was 31.37¡¾9.47mg/dl, that of copper 80.54¡¾17.54ug/dl, that of ceruloplasmin 11.34¡¾6.37mg/dl, that of zinc 92.81¡¾79.74ug/dl, that of iron 198.98¡¾86.07 ug/dl. 2)...
A clinical studies on Wilson's disease.
Won Kyu Lee, Ki Sup Chung, Chang Jun Coe
Clin Exp Pediatr. 1989;32(11):1496-1502.   Published online November 30, 1989
The 12 cases of Wilson disease younger than the age of 18 years were observed at Severance hospital between Jan. 1980 and July 1988 and we obtained following results. 1) The mean age was 14 years old and male to female ratio was 2:1 2) The younger the patient, the clinical symptoms predominantly manifested hepatic dysfunction and the older patient manifested neurologic symptoms. 3) Kayser-Fleischer’s ring was the...
Case Report
Two Cases of Wilson's Disease.
Myung Ho Kang, Byoung Tae Kim, Jae Ock Park, Sang Jhoo Lee
Clin Exp Pediatr. 1986;29(3):336-341.   Published online March 31, 1986
The authors experienced two cases of hepatic from of Wilson* s disease, which diagnosis were confirmed by family history, their characteristic clinical manifestations with hepatic symptoms, Kayser-Fleischer ring and laboratory data with decreased serum ceruloplasmin and copper level and increased urine copper excretion. Case 1： An 8 8/12 year-old boy with chief complaints of abdominal distension and jaundice showed Kayser-Fleischer ring...
Original Article
Clinical Assessment on Wilson's Disease.
In Sil Lee, Young Yul Koh, Hyung Ro Moon
Clin Exp Pediatr. 1981;24(12):1165-1172.   Published online December 15, 1981
The clinical and laboratory manifestations in ten children with Wilson* s disease are described. The average at onset of symptoms in the eight symptomatic patients was ten years, and male to female ratio was 6 to 4. Kayser-Fleisher rings were present in eight patients. Splenomegaly and hepatomegaly were noted in. four patients and generalized edema was present in six patients. Less...
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