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Case Report
Neonatology (Perinatology)
Case of mucinous adenocarcinoma of the lung associated with congenital pulmonary airway malformation in a neonate
Juneyoug Koh, Euiseok Jung, Se Jin Jang, Dong Kwan Kim, Byong Sop Lee, Ki-Soo Kim, Ellen Ai-Rhan Kim
Clin Exp Pediatr. 2018;61(1):30-34.   Published online January 22, 2018

Congenital pulmonary airway malformation (CPAM), previously known as congenital cystic adenomatoid malformation, is a rare developmental lung abnormality associated with rhabdomyosarcoma, pleuropulmonary blastoma, and mucinous adenocarcinoma of the lung. We report an unusual case of a 10-day-old male newborn with a left lower lobe pulmonary cyst who underwent lobectomy, which revealed type II CPAM complicated by multifocal mucinous adenocarcinoma. KRAS...

Oncology
Unusual malignant neoplasms of ovary in children: two cases report
Ali Ghribi, Aicha Bouden, Manef Gasmi, Mourad Hamzaoui
Clin Exp Pediatr. 2016;59(Suppl 1):S107-S111.   Published online November 30, 2016

Sex cord tumors with annular tubules are known to originate from the sex cord of embryonic gonads that synthesize Sertoli cells, Leydig cells, granulosa cells, and theca cells of the ovarian stroma, while ovarian small cell carcinoma of the hypercalcemic type is a type of neuroendocrine tumor. Both these tumors are uncommon, potentially malignant neoplasms in children. We report the...

Hand-Foot syndrome induced by sorafenib, a multitargeted tyrosine kinase inhibitor, in a patient with advanced renal cell carcinoma
Seung Hyun Lee, Sung Hun Noh, Sun Young Kim, Kyu Yun Jang, Pyoung Han Hwang
Clin Exp Pediatr. 2009;52(1):119-123.   Published online January 15, 2009
Renal cell carcinoma (RCC) arising from epithelial cells of the renal tubules is a highly aggressive and malignant tumor in all ages; however, it rarely occurs in children. the standard treatment for RCC is radical nephrectomy with lymph node dissection when the tumor is localized and can be completely resected. Adjuvant chemotherapy, radiotherapy, and immunotherapy are used for pediatric patients...
Original Article
Jagged1 mutation analysis in Alagille syndrome patients
Jae Sung Ko, Hye Ran Yang, Kyung Mo Kim, Jeong Kee Seo
Clin Exp Pediatr. 2006;49(5):519-522.   Published online May 15, 2006
Purpose : Alagille syndrome is an autosomal dominant disorder with developmental abnormalities affecting the liver, heart, eyes, vertebrae, and craniofacial region. The Jagged1(JAG1) gene, which encodes a ligand of Notch, has been found mutated in Alagille syndrome. The aim of the study was to investigate the mutation analysis of JAG1 gene in Korean patients with Alagille syndrome. Methods : Genomic DNA...
Case Report
A Case of Basaloid Squamous Cell Lung Carcinoma in an 11-year-old Boy
Nyeon Cheon Kim, Seung Soo Kim, Won Suk Seo, Kyeong Bae Park, Joon Soo Park, Sang Mann Shin, Hyun Deuk Cho
Clin Exp Pediatr. 2005;48(2):208-211.   Published online February 15, 2005
Primary lung cancer is unusual in children; the squamous cell variant is extremely rare. Lung cancer is classified by histologic types into small-cell lung cancer, non-small cell lung caner, carcinoid, mucoepidermoid carcinoma, and adenoid cystic carcinoma. Furthermore, non-small cell lung cancer is subclassified into adenocarcinoma, large-cell carcinoma, and squamous cell carcinoma. The incidence of lung cancer is influenced by smoking,...
A Case of Teratocarcinoma with Central Diabetes Insipidus
Jong Hoon Kim, In Seok Lim, Eung Sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2004;47(4):453-457.   Published online April 15, 2004
Central diabetes insipidus is a rare disorder that can result as a consequence of diverse etiologies, including malformations, autoimmune, infiltrative(e.g. neoplastic or histiocytosis) or traumatic processes, as well as mutations in the gene encoding arginine vasopressin. Idiopathic central diabetes insipidus is a diagnosis of exclusion, one that has been made less frequently through the decades. Idiopathic central diabetes insipidus in...
A Case of Primary Small Cell Bronchogenic Carcinoma Detected by Bronchoscopy in a Child
Seon Ju Song, Chang Keun Kim, Churl Young Chung
Clin Exp Pediatr. 1999;42(11):1599-1603.   Published online November 15, 1999
While the frequency of primary carcinoma of the lung has recently increased in adults, it is rare in the pediatric age group. The various adult types of bronchogenic carcinoma such as squamous cell, small cell, large cell, and adenocarcinoma, are extremely rare in children. Twenty to 30 cases of primary bronchogenic carcinoma of the lung in children under 15 years...
A Case of Bronchial Mucoepidermoid Carcinoma in Child
In Jeong Kim, Jin Soo Hwang, In Seok Kim, Byung Ju Kim, Jae Sook Ma
Clin Exp Pediatr. 1999;42(4):580-583.   Published online April 15, 1999
Bronchial mucoepidermoid carcinoma is very rarely encountered in children. We report a case of bronchial mucoepidermoid carcinoma in a 10-year-old boy who presented with persistent cough and atelectasis. Bronchoscopic examination showed a tumor mass occluding the right bronchus intermedius, and the mass was removed by bronchoscopy. The results of the pathological examination revealed low-grade mucoepidermoid carcinoma. He underwent right middle...
Two Cases of Thymic Carcinoma in Childhood
Young Ah Lee, Jin Young Park, Hye Lim Jung, Moon Soo Par, Hyoung Soo Choi, Eun Sun Yoo, Hyo Seop Ah
Clin Exp Pediatr. 1999;42(3):424-429.   Published online March 15, 1999
Thymic carcinoma is a malignant neoplasm arising from the thymic epithelium, and is known to be extremely uncommon in the pediatric population. The tumor is clinically highly aggressive with frequent local intrathoracic spread and extrathoracic metastases detected in the majority of patients at initial diagnosis and often shows minimal or no response to conventional chemotherapy. We experienced two pediatric patients...
Mucoepidermoid Carcinoma of the Bronchus in A 9-year-old Child
Jin Ah Son, Hong Hoe Koo, Sang Il Lee, Jhingook Kim
Clin Exp Pediatr. 1998;41(6):837-840.   Published online June 15, 1998
The appearance of mucoepidermoid carcinoma of the lung during in childhood is an uncommon neoplasm. Symptoms of progressive bronchial obstruction proceed the recognition of this lesion. Adequate surgical resection precludes the need for further radiation therapy or chemotherapy. The patient underwent bronchoscopy to investigate the cause of chronic coughing, which revealed a tumor. Histological examination confirmed the diagnosis of mucoepidermoid...
Original Article
Results of Chemotherapy of Hepatoblastoma and Hepatocellular Carcinoma in Children
Kyung Duk Park, Gi Woong Seong, Jae Kyung Lee, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1995;38(2):195-206.   Published online February 15, 1995
Purpose : Surgical excision has been the primary treatment for hepatoblastoma and hepatocellular carcinoma. However, at presentation, only one third of such tumors are surgically resectable. Without operation, the disease is fatal. Therefore, neoadjuvant chemotherapy has been introduced for conversion of the unresectable tumors into the resectable ones. We studied th e effects of chemotherapy for hepatic malignancy in children. Methods...
Case Report
A Case of Childhood Adenocarcinoma
Mi Jung Park, Moon Sung Psrk, Seunng Hwang Oh, Chuhl Joo Lyu, Ki Sup Chung, Byung Soo Kim
Clin Exp Pediatr. 1994;37(1):109-114.   Published online January 15, 1994
Gastric adenocarcinoma in childhood is an extremely rare disease with poor prognosis. We experienced a case in which a 14 year old female patient who was admitted with complaints of abdominal pain, indigestion and obstipation. Her physical examination revealed positive Blumer's rectal shelf, positive ascitic fluid cytology and typical radiologic and endoscopic findings suggesting gartric adenocarcinoma. She showed symptomatic improvement...
Original Article
Carcinomas in Childhood -A 10-Year Experience in Seoul National University Hospital-
Hong Hoe Koo, Kyung Duk Park, Hye Lim Jung, Sang Kyu Park, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(10):1369-1376.   Published online October 15, 1992
Carcinomas in childhood differ from those in adults in their frequency, histologic type, and distribution of primary sites. In children, carcinomas are rare and few series have been published containing sufficient mumbers of cases to permit a reliable account of the incidence and survival of children with carcinoma. During a 10-year period, 1982-1991, we observed 40 patients less than 16...
A case of primary hepatocellular carcinoma following vertical transmission of hepatitis B virus in a child.
Soo Kyoung Lee, Ki Sup Chung, Sun Won Hong, Chan Il Park
Clin Exp Pediatr. 1991;34(11):1573-1580.   Published online November 30, 1991
Authors experienced a case of primary hepatocellular carcinoma in a 7 year 9 month old male patient, who was admitted to our hospital due to abdominal pain on right upper quadrant and anorexia during last two months. On family history, his mother was HBs Ag and HBe Ag carrier. On past history, he was admitted to a hospital due to persistant jaundice at...
Two cases of nasopharyngeal carcinoma in children.
Tae Sun Ha, Chul Ho Jang, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):587-593.   Published online April 30, 1991
Nasopharyngeal carcinoma is a primary malignancy of nasopharyngeal epithelium, firstly de- scribed as a separate entity by Regaud and Schmincke in 1921. Although it is a rare tumor, reprsent- ing less than 1% of pediatric malignancies, it accounts for 9% of the nasopharyngeal neoplasms of childhood, and has not been reported in Korean child. We experienced two cases of nasopharyngeal carcinoma in a 10...
Adrenocortical carcinoma in a twelve month old male infant.
Woo Ryoung Lee, Kyoung Whan Oh, Chang Hwi Kim, Sang Jhoo Lee
Clin Exp Pediatr. 1991;34(1):137-143.   Published online January 31, 1991
Adrenocortical carcinoma is a rare disease in childhood. Most of these carcinomas are functional, produc- ing endocrine abnormalities such as Cushing syndrome, virilization, precocious puberty, hyperaldosteronism or feminization. We experienced a case of adrenocortical carcinoma in a 12 month old male infant who exhibited features of Cushing syndrome, Virilization, precocious puberty and hyperaldosteronism, which were due to functional adrenocortical carcinoma. Microscopic examination revealed cellular pleomorphism...
A Case of Adrenal Cortical Carcinoma.
Ho Won Kang, Hong Ja Kang, Hong Bae Kim, Ji Sub Oh
Clin Exp Pediatr. 1990;33(8):1159-1165.   Published online August 31, 1990
This is a case report of adrenal cortical carcinoma in a 2 year 7 month old male patient who was diagnosed by clinical features, endocrinologic studies, radiologic studies and pathologic examina- tions. Cushing syndrome and virilization caused by adrenal cortical carcinoma were found. Left total adrenalectomy was performed. No evidence of metastasis was found at the time of operation. 3 months later, lung metastases...
A Case of Mucinous Cystadenocarcinoma in a Premenarchal Girl.
Hong Hoe Koo, Sang Oh Na, In Sang Jeon, Hyo Seop Ahn, Wan Suk Park, Suk Koo Lee, Kwi Won Park, Chong Jai Kim, Je Geun Chi
Clin Exp Pediatr. 1990;33(1):124-128.   Published online January 31, 1990
In childhood, cancer of the ovary is highly unusual. It is responsible for only 1—2% of cancers found in patients under the age of 17. The frequency with which the various histologic types of ovarian neoplasm occur in childhood differs from that in adults. Epithelial tumors account for 70% to 80% of ovarian neoplasms in adults but only 20% in patients less than...
Twelves Cases of Thyroid Carcinoma in Children.
Yong Woo Choi, Myung Ho Cho, O Kyung Lee, Myung Ho Lee
Clin Exp Pediatr. 1986;29(6):661-667.   Published online June 30, 1986
We obtained following results by analysis of 12 cases of thyroid carcinoma in patient under 15 years of age who were admitted to Presbyterian Medical Center, Chon-ju from January 1975 to December 1984. 1) The ratio between male and female patients was 1 : 3. Patients over 12 years of age totalled 7 cases(58.3%). The youngest patient was 5 years and...
Case Report
Childhood Bronchial Mycoepidermoid Tumor a Case Report and Review of the Literature.
B Ahn, H D Cha, Y D Kwon, C M Kang
Clin Exp Pediatr. 1985;28(11):1158-1162.   Published online November 30, 1985
Mucoepidermoid carcinoma of the bronchus in a 13-years-old boy was presented. The case was diagnosed by bronchoscopic examination and with the findings of light microscopy. There was no evidence of metastasis and tumor was completely removed by mid and lower lobectomy. Mucoepidermoid carcinoma is a very rare tumor especially in children arising from the bronchial gland.
A Case of Primary Mucinous Adenocarcinoma of the Colon in Children.
Chi Ho Yoon, Kyung Ae Lee, Jung Mo Ryu, Soon Hee Choi, Kyu Geun Cho
Clin Exp Pediatr. 1985;28(11):1136-1140.   Published online November 30, 1985
Malignant diseases of tte colon are rare during childhood. The etiology of disesaes has not not been clearly defined, but diet, exposure to farm chemical, carcinogens, bile acid, clostria, and genetic factors are associated with large bowel cancer. 50% of the adenocarcinoma in children are of the mucin producing variety. The prognosis of childhood cancer of the colon is very poor,...
A Case of Primary Hepatocellular Carcinoma in Infancy .
H Y Kim, S W Ahn, Y S Kim, C Y Kim, J W Yang
Clin Exp Pediatr. 1984;27(12):1227-1233.   Published online December 31, 1984
Primary hepatoma is relatively rare tumor in infants an children. The incidence among 1000 hospitalized children in pediatric clinic is about 0.05-0.06. The author experienced, a case of primary hepatoma occurred, in 3-months-old male who was admitted to the Pusan II Sin Women’s Hospital with symptom of progressively growing palpable mass on the right upper quadrant. Under the procedure of explorative laparatomy, the hard mass...
Adrenal Cortical Carcinoma in a Nineteen Month Old Girl.
Sei Weon Yang, Jong Jin Seo, Hyung Ro Moon
Clin Exp Pediatr. 1984;27(4):413-418.   Published online April 30, 1984
Adrenal carcinoma is a rare disease both in adults and in children. Most of these tumors are functional, especially in children, producing endocrine syndromes such as Cushing syndrome, virilization, feminization or precocious puberty. The authors report a nineteen month old girl who exhibited features of Cushing syndrome and virilization caused by adrenal cortical carcinoma measuring 5.5X5.0X2.8 cm. She was successfully...
A Case of Thyroid Papillary Adenocarcinoma.
Duk Hi Kim, Chul Lee, Pyung Kil Kim, Byung Soo Kim, Yi Ho Hwang, Kyung Sik Lee, Woo Hee Chung
Clin Exp Pediatr. 1984;27(3):288-292.   Published online March 31, 1984
We report a case of thyroid papillary adenocarcinoma in a 5 year 1 month old boy. His major problem was palpable thyroid nodule & cervical lymph nodes. Extensive bilateral pulmonary metastasis was noticed. The metastatic thyroid carcinoma was regressed after therapeutic doses of radioiodine without total thyroidectomy.
Four Cases of Papillary Thyroid Cancer in Childhood.
Sei Weon Yang, Sei Won Park, In Sil Lee, Hyo Seup Ahn, Hyung Ro Moon, Chang Yee Hong, Kwi Won Park, Je Geun Chi
Clin Exp Pediatr. 1984;27(3):282-287.   Published online March 31, 1984
Papaillary thyroid cancer is a rare lesion in children. It progresses slowly and its prognosis is relatively good. A painless nodule in the thyroid or in the neck is the usual first evidence of disease. Cervical lymph node involvement is usually present at the time of the initial diagnosis and is often bilateral. The lungs are the most common site...
A Case of Cushing's Syndrome.
Seong Ja Jeon, Oh Kyung Lee, Keun Chull Choi, Myung Ho Lee, Jong Deok Kim
Clin Exp Pediatr. 1983;26(9):928-933.   Published online September 30, 1983
We experienced a Cushing’s syndrome which was caused by adrenocortical carcinoma in 8-year-old boy. He has suffered from obesity, moonface and growth retardation for 2 years. The diagnosis was confirmed by clinical symptoms, biochemical studies, X-rays and pathologic examinations. A total adrenalectomy was impossible because of far extended mass to adjacent organ, so only tissue biopay was done. After surgery, he received radiation...
A Case of Primary Mucinous Adinocarcinoma (Colloid) of Colon in Children.
Kyoung Nam Kim, Won Ik Lee, Sung Chul Son, Poong Man Lee
Clin Exp Pediatr. 1983;26(4):397-401.   Published online April 30, 1983
Carcinoma of the colon in childhood has remained extremely rare, and especially, primary carcinoma of colon was often escapes early diagnosis because of a lack of awarenss of its occurrence in pediatric age group. Recently we experienced a case of mucinous adenocarcinoma (Colloid carcinoma) of descending colon without predisposing conditions which may increased the risk of development of colorectal cancer in 13...
A Case of Cushing's Syndrome Associatied with Hypertensive Encephalopathy.
Choong Rae Kim, In Soon Park, Do Seung Lee, Jae Sun Park, Kee Ryo Chang, Soon Yong Lee
Clin Exp Pediatr. 1981;24(1):80-84.   Published online January 15, 1981
A 8-yrs-old boy was admitted because of convulsion and coma. The diagnosis of Cushing's syndrome(key word) associated with hypertensive encephalopathy(key word) due to right adrenocortical carcinoma(key word) was made by clinical features, biochemical studies, radiological studies and pathological examination. The tumor was successfully resected by right adrenalectomy. But 22 months later after operation, he died of dyspnea and heart failure....
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