Search

  • HOME
  • Search
Original Article
Neonatology (Perinatology)
The protective effect of CXC chemokine receptor 2 antagonist on experimental bronchopulmonary dysplasia induced by postnatal systemic inflammation
Seung Hyun Lee, Chang Won Choi
Clin Exp Pediatr. 2021;64(1):37-43.   Published online July 15, 2020
Question: Can CXC chemokine receptor 2 (CXCR2) antagonist preserve alveolarization by attenuating the inflammation induced by systemic lipopolysaccharide (LPS) administration in a rat model of bronchopulmonary dysplasia (BPD)?
Finding: CXCR2 antagonist significantly decreased neutrophil counts in bronchoalveolar lavage fluid and peripheral blood induced by systemic LPS administration and restored alveolarization in newborn rats.
Meaning: CXCR2 antagonist protected the lungs from the inflammation in a rat model of BPD.
Effect of red blood cell transfusion on short-term outcomes in very low birth weight infants
Eui Young Lee, Sung Shin Kim, Ga Young Park, Sun Hyang Lee
Clin Exp Pediatr. 2020;63(2):56-62.   Published online February 6, 2020
Question: Does RBC transfusion affect the short-term outcomes of VLBW infants?
Finding: The results showed that RBC transfusion was significantly related to the incidence of BPD (OR, 5.42; P<0.001) and NEC (OR, 3.40; P=0.009).
Meaning: Careful consideration of the patient’s clinical condition and appropriate guidelines is required before administering RBC transfusions.
Review Article
Neonatology (Perinatology)
Bronchopulmonary dysplasia: how can we improve its outcomes?
Tae-Jung Sung
Clin Exp Pediatr. 2019;62(10):367-373.   Published online May 17, 2019
Bronchopulmonary dysplasia (BPD) is a chronic lung disease of preterm infants with multiple factors affected from prenatal to postnatal periods. Despite significant advances in neonatal care over almost 50 years, BPD rates have not decreased; in fact, they may have even increased. Since more preterm infants, even at periviable gestational age, survive today, different stages of lung development affect the...
Original Article
Neonatology (Perinatology)
Association between vitamin D level at birth and respiratory morbidities in very-low-birth-weight infants
Ian Kim, Sung Shin Kim, Jee In Song, Seock Hwa Yoon, Ga Young Park, Yong-Wha Lee
Clin Exp Pediatr. 2019;62(5):166-172.   Published online October 24, 2018

Purpose: This study aimed to evaluate vitamin D status at birth in very-low-birth-weight infants (VLBWIs: <1,500 g) and to determine the association between vitamin D level and respiratory morbidity. Methods: A retrospective study was conducted at Soonchunhyang University Bucheon Hospital between November 2013 and November 2017. We collected blood samples and data on respiratory morbidity from 230 VLBWIs on the first...
Review Article
Neonatology (Perinatology)
Chorioamnionitis: Is a major player in the development of bronchopulmonary dysplasia?
Chang Won Choi
Clin Exp Pediatr. 2017;60(7):203-207.   Published online July 31, 2017

Chorioamnionitis is an inflammation in the fetal membranes or placenta. When chorioamnionitis develops, fetal lungs are exposed to inflammatory cytokines and mediators via amniotic fluid. Because inflammation plays a pivotal role in the development of bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity, fetal lung inflammation induced by chorioamnionitis has been considered to be one of the major pathogenetic...

Respiratory support with heated humidified high flow nasal cannula in preterm infants
Ga Won Jeon
Clin Exp Pediatr. 2016;59(10):389-394.   Published online October 17, 2016

The incidence of bronchopulmonary dysplasia (BPD) has not decreased over the last decade. The most important way to decrease BPD is by weaning the patient from the ventilator as soon as possible in order to reduce ventilator-induced lung injury that underlies BPD, and by using a noninvasive ventilator (NIV). Use of a heated, humidified, high flow nasal cannula (HHHFNC), which...

Original Article
Low levels of tissue inhibitor of metalloproteinase-2 at birth may be associated with subsequent development of bronchopulmonary dysplasia in preterm infants
Choae Lee, Jaewoo An, Ji Hee Kim, Eun Sun Kim, Soo Hyun Kim, Yeon Kyung Cho, Dong Hyun Cha, Man Yong Han, Kyu Hyung Lee, Youn Ho Sheen
Clin Exp Pediatr. 2015;58(11):415-420.   Published online November 22, 2015
Purpose

Bronchopulmonary dysplasia (BPD) is characterized by inflammation with proteolytic damage to the lung extracellular matrix. The results from previous studies are inconsistent regarding the role of proteinases and antiproteinases in the development of BPD. The aim of the present study was to investigate whether matrix metalloproteinase (MMP)-8, MMP-9, tissue inhibitor of metalloproteinase (TIMP)-2, and TIMP-1 levels in the serum of...

The relationship between eosinophilia and bronchopulmonary dysplasia in premature infants at less than 34 weeks' gestation
Joo Yun Yang, Jihei Cha, So-Yeon Shim, Su Jin Cho, Eun Ae Park
Clin Exp Pediatr. 2014;57(4):171-177.   Published online April 30, 2014
Purpose

Eosinophilia is common in premature infants, and its incidence increases with a shorter gestation period. We investigated the clinical significance of eosinophilia in premature infants born at <34 weeks gestation.

Methods

We analyzed the medical records of premature infants born at <34 weeks gestation who were admitted to the neonatal intensive care unit at Ewha Womans University Mokdong Hospital between January 2003...

Serological investigation of Ureaplasma urealyticum in Korean preterm infants
Ho Seon Eun, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
Clin Exp Pediatr. 2013;56(11):477-481.   Published online November 27, 2013
Purpose

Ureaplasma colonization is related with perinatal complications in preterm infants. Little is known about the difference in virulence among various Ureaplasma urealyticum serovars. The aim of this study was to determine U. urealyticum serovars of preterm infants in order to assess whether any of the serovars were associated with bronchopulmonary dysplasia (BPD).

Methods

Three hundred forty-four preterm infants with a gestational age...

Review Article
Lung interstitial cells during alveolarization
Chang Won Choi
Clin Exp Pediatr. 2010;53(12):979-984.   Published online December 31, 2010

Recent progress in neonatal medicine has enabled survival of many extremely low-birth-weight infants. Prenatal steroids, surfactants, and non-invasive ventilation have helped reduce the incidence of the classical form of bronchopulmonary dysplasia characterized by marked fibrosis and emphysema. However, a new form of bronchopulmonary dysplasia marked by arrest of alveolarization remains a complication in the postnatal course of extremely low-birth-weight infants....

Pulmonary hypertension in infants with bronchopulmonary dysplasia
Gi Beom Kim
Clin Exp Pediatr. 2010;53(6):688-693.   Published online June 23, 2010

An increase in the number of preterm infants and a decrease in the gestational age at birth have resulted in an increase in the number of patients with significant bronchopulmonary dysplasia (BPD) and secondary pulmonary hypertension (PH). PH contributes significantly to the high morbidity and mortality in the BPD patients. Therefore, regular monitoring for PH by using echocardiography and B-type...

Original Article
The effects of neonatal ventilator care or maternal chorioamnionitis on the development of bronchopulmonary dysplasia
Ki Tae Yun, Whan Dong Lee, Sang Geel Lee
Clin Exp Pediatr. 2009;52(8):893-897.   Published online August 15, 2009

Purpose:Advances in neonatal intensive care have improved the survival rate of low-birth-weight infants, but mild bronchopulmonary dysplasia (BPD) with the accompanying need for prolonged oxygen supplement remains problematic. Maternal chorioamnionitis and neonatal ventilator care affect the development of BPD. This study aimed to examine whether maternal chorioamnionitis or neonatal ventilator care affect the development of BPD dependently or independently. Methods:We performed a retrospective study...
Montelukast as an add-on therapy in bronchopulmonary dysplasia
He Min Kim, Ji Eun Song, Soon Min Lee, Min Soo Park, Kook In Park, Ran Namgung, Chul Lee
Clin Exp Pediatr. 2009;52(2):181-186.   Published online February 15, 2009
Purpose : Inflammation plays a potential role in the pathogenesis of bronchopulmonary dysplasia (BPD). Strategies for preventing BPD include respiratory management, antioxidants, nutritional treatment, and others such as anti-inflammatory agents. We aimed to assess the safety, tolerability, and efficacy of montelukast (MK), a cysteinyl leukotriene 1 receptor antagonist, as an add-on therapy in BPD. Methods : In addition to currently available...
The effects of early surfactant treatment and minimal ventilation on prevention of bronchopulmonary dysplasia in respiratory distress syndrome
Jong Jin Park, Pil Sang Lee, Sang Geel Lee
Clin Exp Pediatr. 2009;52(1):44-49.   Published online January 15, 2009
Purpose : Early surfactant treatment and minimal ventilation, bronchopulmonary dysplasia needed prolonged oxygen supplement is a problem. This study aimed to report the effects of early surfactant treatment and minimal ventilation on the prevention of bronchopulmonary dysplasia in respiratory distress syndrome. Methods : We retrospectively studied 139 premature newborn infants (gestational age, 36 weeks; birth weight, 1,500 gm) admitted to...
Review Article
Recent progress in the understanding of clinical characteristics, epidemiology, and pathogenesis of new bronchopulmonary dysplasia
Beyong Il Kim
Clin Exp Pediatr. 2009;52(1):6-13.   Published online January 15, 2009
Recent advances in perinatal care have resulted in improved survival of extremely low birth weight infants (ELBWI). However, bronchopulmonary dysplasia (BPD) remains one of the major complications in ELBWI. BPD was originally described over 40 years ago; the clinical characteristics, epidemiology, and pathogenesis of BPD have changed markedly through this period. In this article, I have reviewed recent progress in...
Original Article
The effect of restricted fluid intakes in the first week of life on the risk of bronchopulmonary dysplasia and patent ductus arteriosus in very low birth weight infants
Hoe Kyoung Koo, Eun Na Choi, Ran Namgung, Min Soo Park, Kook In Park, Chul Lee
Clin Exp Pediatr. 2007;50(6):536-542.   Published online June 15, 2007
Purpose : We investigated the effects of restricted fluid in the first 7 days of life on the risk of bronchopulmonary dysplasia (BPD) or patent ductus arteriosus (PDA) in very low birth weight (VLBW) infants. Methods : Eighty three VLBW infants who lived more than 28 days were selected. The amount of daily maintenance fluid was determined by calculation of insensible...
High-resolution computed tomography findings of lung parenchyme changes in very low birth weight infants treated with oxygen
Young Man Jin, David Chanwook Chung, Young Pyo Chang, Yung Suk Lee, En Sun Lee
Clin Exp Pediatr. 2007;50(3):255-261.   Published online March 15, 2007
Purpose : The objective of this study is to observe high-resolution computed tomography (HRCT) findings of lung parenchyme in very low birth weight (VLBW) infants between the corrected age of 38-42 weeks who were treated with oxygen after birth, and to compare them to the clinical severity of bronchopulmonary dysplasia (BPD). Methods : The lungs of fourty-four VLBW infants with gestational...
Medical Lecture Course
Factors Involved in Lung Development and Alveolarization
Min Soo Park
Clin Exp Pediatr. 2004;47(10):1031-1035.   Published online October 15, 2004
Lung development is a sum of processes that involve harmonized orchestration of expressions of various factors in time and space. The mastermind governing these phenomena is not known, but cumulative efforts so far have helped us gain some insights as to what are involved in and how complex the developmental process is. Beginning as primitive foregut, lungs undergo processes called...
Original Article
Peripheral Neutrophil Count and Respiratory Failure in Preterm Infant
Kum Joo Lee, Soo Young Yun, Ran Lee, Jae Ho Hean, Ghee Young Jung, Jin Hee Park, Young Sun Park
Clin Exp Pediatr. 2002;45(5):596-602.   Published online May 15, 2002
Purpose : The purpose of this study was to analyze the association of peripheral neutrophil count with the development of respiratory failure in preterm infants. Methods : A retrospective study was conducted from January 1993 to December 1999 on 44 preterm infants, who were admitted to the neonatal intensive care unit of St. Francisco hospital. Preterm infants(birth weight 500 to 1,350...
Classification and Risk Factors for Chronic Lung Disease(CLD) of Prematurity : Classical CLD Versus Atypical CLD
Chang Won Choi, Beyong Il Kim, Heui Seung Jo, Jun Dong Park, Chong Jae Kim, Bo Hyun Yoon, Jung-Hwan Choi
Clin Exp Pediatr. 2001;44(11):1222-1232.   Published online November 15, 2001
Purpose : We tried to classify the different type of CLD and assess the risk factors for classical CLD and atypical CLD. Methods : Retrospective cohort analysis was done in 120 preterm infants with birth weights less than 1,500 g who were admitted to NICU in Seoul National University Children's Hospital between Jan. 1993 and Dec. 1998 and survived more...
Erratum
Association of Early Postnatal Neutropenia and Development of Bronchopulmonary Dysplasia in Preterm Infants
Hee Seok Kim, Jun Dong Park, Beyong Il Kim, Jung-Hwan Choi, Chong Ku Yun
Clin Exp Pediatr. 1998;41(8):1033-1040.   Published online August 15, 1998
Purpose : To see if a similar relationship exists between the decreased number of circulating neutrophils and the development of bronchopulmonary dysplasia(BPD) in preterm infants, we tried to test the hypothesis that claims that preterm infants, who develop BPD, have decreased number of circulating neutrophils than those who do not develop BPD. Methods : A retrospective cohort study was conducted in...
Case Report
A Case of Dexamethasone induced Hypertrophic Cardiomyopathy in Neonate with Bronchopulmonary Dysplasia
Youn Jung Choi, Soon Mi Jung, Jae Kyun Yoon, Ki Hyeng Lee, Chang Sung Son, Chang Tocko
Clin Exp Pediatr. 1998;41(5):711-715.   Published online May 15, 1998
Although hypertrophic cardiomyopathy is uncommon in infant and children, we have experienced a case of dexamethasone induced hypertrophic cardiomyopathy in preterm baby who had bronchopulmonary dysplasia. This patient had hyaline membrane disease. Therefore, he received prolonged mechanical ventilation that resulted in bronchopulmonary dysplasia. After we carried out dexamethasone therapy for 7 days, hypertrophic cardiomyopathy appeared in his echocardiographic finding. We...
Original Article
Risk Factors of Bronchopulmonary Dysplasia in Premature Infants Treated with Mechanical Ventilation and Restrictive Fluid Therapy
Min Soo Park, Kook In Park, Hye Jung Choo, Moon Sung Park, Ran Namgung, Chul Lee, Dong Gwan Han
Clin Exp Pediatr. 1994;37(10):1357-1363.   Published online October 15, 1994
In addition to many of the widely accepted risk factors of bronchopulmonary dysplasia(BPD), such as prematurity, oxygen toxicity, barotrauma, and infection, the amount of fluid intake during the early phase of life has recently been reported to be an important factor, especially the amount of colloid. Forty-one premature infants who were admitted to the NICU of Severance Hospital, Yonsei University...
Risk Factors and Outcome of Bronchopulmonary Dysplasia
Beyong Il Kim, Yun Sil Chang, Dong Woo Son, Hae Kyung Han, Jung-Hwan Choi, Chong Ku Yun, In One Kim, Kyung Mo Yeon, Je G. Chi
Clin Exp Pediatr. 1994;37(1):78-88.   Published online January 15, 1994
The 45 neonates with bronchopulmonary dysplasia among 355 neonates who were managed with mechanical ventilation and oxygen therapy in NICU of Seoul National University Chhildren's Hospital from January 1, 1968 to December 31, 1991, were analyzed for risk factors and outcome. The results were as follows: 1) The incidence of bronchopulmonary dysplasia was 12.7% 2) Respiratory Distress Syndrome was most common underlying problem. 3)...
The Therapeutic Effects of Dexamethasone in Bronchopulmonary Dysplasia
Min Joong Kwon, Kook In Park, Min Soo Park, Ran Namgung, Chul Lee, Dong Kwan Han
Clin Exp Pediatr. 1993;36(12):1672-1680.   Published online December 15, 1993
We observed clinical features of 18 bronchopulmonary dysplasia (BPD) patients who were admitted to the neonatal intensive care unit in the Severance Hospital of Yonsei University College of Medicine from January 1. 1987 to June 30. 1991. Eight patients in whom ventilator settings were unchanged from for more than 5 days because of lack of improvement in pulmonary function. ...
A case of bronchopulmonary dysplasia.
Sun A Chun, Byung Jun Choi, Bo Kyung Cho, Chung Sik Chun, Sung Hoon Cho
Clin Exp Pediatr. 1989;32(11):1553-1559.   Published online November 30, 1989
The development of respiratory management of the newborn has improved the survival rates of respiratory distress syndrome in these two decades. But the incidence of complication associated with this management has been increased. Although the pathogenesis of bronchopulmonary dysplasia has not been clearly established yet, bronchopulmonary dysplasia is one of the major complication of the mechanical ventilation. There are several factors in the development of...
  • PubMed Central
  • PubMed
  • Scopus
  • Directory of Open Access Journals (DOAJ)