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Original Article
Increased risk of refractory Mycoplasma pneumoniae pneumonia in children with atopic sensitization and asthma
Jeong Eun Shin, Bo Ram Cheon, Jae Won Shim, Deok Soo Kim, Hae Lim Jung, Moon Soo Park, Jung Yeon Shim
Clin Exp Pediatr. 2014;57(6):271-277.   Published online June 30, 2014
Purpose

A nationwide outbreak of Mycoplasma pneumoniae pneumonia (MP) refractory to macrolide antibiotics occurred in Korea during 2011. Steroid therapy has been reported to be both efficacious and well tolerated in pediatric patients with refractory MP. We compared clinical features and laboratory characteristics between children with refractory MP requiring steroid treatment and those with macrolide-responsive MP and evaluated the risk factors...

Review Article
Determinants of sensitization to allergen in infants and young children
Hyeong Yun Kim, Youn Ho Shin, Man Yong Han
Clin Exp Pediatr. 2014;57(5):205-210.   Published online May 31, 2014

Atopic sensitization is a complex phenomenon that changes dynamically with age throughout childhood; its prevalence increases with age in young children. Additionally, with increasing age, the prevalence of sensitization to inhalant allergens and the prevalence of polysensitization to allergens increase. It is also well established that the development of atopic sensitization is the result of a complex interplay of genetic...

Original Article
Bronchial Hyperresponsiveness and Atopy in 6-8 Year Old Children According to the History of Wheezing in Early Childhood
Jinho Yu, Young Yoo, Hee Kang, Young Yull Koh
Clin Exp Pediatr. 2004;47(8):873-878.   Published online August 15, 2004
Purpose : It is becoming generally recognized that wheezing in early childhood is a heterogeneous condition and does not always develop into asthma. This study aimed to determine characteristics of wheezing phenotypes in early childhood and investigate their relation to asthma. Methods : Two hundreds and sixty 6-8 year old children with past or present wheezeing were enrolled, and their history...
The Relationship between House Dust Mite Sensitization and Month Birth Distribution in Children with Respiratory Allergy
Eun Kyeong Kang, Kyu Min Na, Hee Kang, Young Yoo, Young Yull Koh
Clin Exp Pediatr. 2003;46(4):370-375.   Published online April 15, 2003
Purpose : It has been suggested that the exposure to aeroallergens during early infancy after birth is important in the subsequent development of sensitization and allergic diseases. In Korea, the level of house dust mites as one of the important aeroallergens is known to be the highest in autumn. The aim of this study was to test whether the distribution...
Exhaled Nitric Oxide Concentration in Children with Asthma and Allergic Rhinitis : Association with Atopy and Bronchial Hyperresponsiveness
Kyu Min Nah, Yang Park, Eun Kyeong Kang, Hee Kang, Young Yull Koh, Sun Wha Lee, Domyung Paek
Clin Exp Pediatr. 2003;46(3):284-290.   Published online March 15, 2003
Purpose : A new airway inflammatory marker, exhaled nitric oxide(ENO) has been reported to correlate with bronchial hyperresponsiveness(BHR) and atopy. The purpose of this study was to analyze the relationship of ENO with BHR or atopy in patients with asthma and with allergic rhinitis. Methods : The subjects consisted of 55 children with asthma, 17 with allergic rhinitis, and 14 healthy...
Age-related Results of Skin Prick Test in Children with Allergic Asthma
Jae Sung Son, Yang Park, Yong Han Sun, Myung Hyun Lee, Young Yull Koh
Clin Exp Pediatr. 2001;44(2):193-199.   Published online February 15, 2001
Purpose : Skin reactivity to different allergens may vary with age, since the degree and type of sensitization may be related not only to genetic factors but also to the intensity and duration of exposure to the allergens. The aim of this study was to evaluate profile of sensitization to airborne allergens according to age in children with allergic asthma. Methods...
Association between Tuberculin Responses and Serum IgE
Pil Ju Jeong, Yong Dae Ham, Jin Hwa Jeong, Jeong Ho Lee
Clin Exp Pediatr. 2000;43(4):502-505.   Published online April 15, 2000
Purpose : Atopy is a state of allergic response, mediated by IgE, to common environmental allergens. In recent decades, there has been an increase in prevalence of atopic disorders in children in developed countries. The factor associated with the rise of atopy incidence may be declining exposure to some infection opportunities. The aim of this study is to determine if...
Relationship between Bronchial Hyperresponsiveness by Methacholine Provocation and the Severity of Asthma Symptoms, Pulmonary Function and Atopy
Sang Hyug Ma, Jung Mi Lee, Byung Hag Lim, Im Ju Kang
Clin Exp Pediatr. 1995;38(2):223-231.   Published online February 15, 1995
Purpose : Bronchial asthma is a disorder that is characteized by symptoms of reversible airway obstruction and increased responsiveness of the bronchus and to quantify the degree of br onchial hyperresponsivenes can be very helpful in determing the severity of disease and the prognosis. But the Methacholine provocation test is not always easy to be performed in all patients. Thus...
Predictive Capacity of Cord Serum IgE for Developement of Atopy.
Hye Ran Byun, Hye Won Lee, Keun Lee
Clin Exp Pediatr. 1989;32(3):390-395.   Published online March 31, 1989
The incidence of atopic disease has increased in recent years and its symptom begins early in life, in many cases during the first year. It is desirable, therefore, to predict the development of atopic disease early in infancy, preferably in neonatal period, so that it can be prevented or, at least, lessened in symptoms by proper management. One hundred and two fullterm newborn...
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