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Original Article
Applying the bacterial meningitis score in children with cerebrospinal fluid pleocytosis: a single center's experience
Jungpyo Lee, Hyeeun Kwon, Joon Soo Lee, Heung Dong Kim, Hoon-Chul Kang
Clin Exp Pediatr. 2015;58(7):251-255.   Published online July 22, 2015

The widespread introduction of bacterial conjugate vaccines has decreased the risk of cerebrospinal fluid (CSF) pleocytosis due to bacterial meningitis (BM) in children. However, most patients with CSF pleocytosis are hospitalized and treated with parenteral antibiotics for several days. The bacterial meningitis score (BMS) is a validated multivariate model derived from a pediatric population in the postconjugate vaccine era and...

Case Report
Severe dapsone hypersensitivity syndrome in a child
So Yoon Choi, Ho Yeon Hwang, Jung Hyun Lee, Jae Sun Park, Min Soo Jang
Clin Exp Pediatr. 2013;56(6):260-264.   Published online June 21, 2013

Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity syndrome, which is characterized by fever, hepatitis, generalized exfoliative dermatitis, and lymphadenopathy. Here, we describe the case of an 11-year-old Korean boy who initially presented with high fever, a morbilliform...

A case of acute aseptic meningitis associated with herpes zoster
Myong A Kim, Rita Miyoung Yu, Kee Hyuck Kim, Hee Jung Chung
Clin Exp Pediatr. 2009;52(6):705-709.   Published online June 15, 2009
Herpes zoster is caused by the varicella-zoster virus (VZV), which affects nerve ganglions. VZV infection may be associated with neurologic complications, which are usually observed after vesicular exanthem. Acute aseptic meningitis is a rare complication of VZV reactivation. We report the case of a previously healthy 14-year-old boy who suffered from aseptic meningitis that was attributed to reactivated VZV infection...
Kikuchi-Fujimoto disease with aseptic meningitis
Se Jin Park, Won Jin Moon, Wan Seop Kim, Kyo Sun Kim
Clin Exp Pediatr. 2009;52(5):622-626.   Published online May 15, 2009
Kikuchi-Fujimoto disease was initially described as a self-limiting histiocytic necrotizing lymphadenitis in Japan in 1972, and is predominantly observed in women under the age of 30 year and in Asian populations. The pathogenesis is still poorly understood but is thought to include infections, and autoimmune and neoplastic diseases. The most common clinical manifestations are fever and painless cervical lymphadenitis. Diagnosis...
Original Article
A study of neuropeptides related to headaches in children with meningeal irritation signs
Bo Gil Seo, Myung Hwan Yoo, Jae Won Shim, Jung Yeon Shim, Hye Lim Jung, Moon Soo Park, Deok-Soo Kim
Clin Exp Pediatr. 2006;49(5):533-538.   Published online May 15, 2006
Purpose : The headache, one of the symptoms of meningitis, is related to abrupt elevation of intracranial pressure(ICP) or stimulation of intracranial nociceptive structure. However, in cases of mild elevation of ICP or normal findings of cerebrospinal fluid(CSF) analysis, patients sometimes complain of headaches. Therefore, other pathways may contribute to the occurrence of headaches in aseptic meningitis or meningismus. We...
Serum and Cerebrospinal Fluid(CSF) Nitric Oxide, Macrophage Inflammatory Protein-1α and Lactoferrin Levels in Aseptic Meningitis
Young Seo, Jung Yeon Shim, Jae Won Shim, Deok Su Kim, Hye Lim Jung, Moon Soo Park
Clin Exp Pediatr. 2005;48(1):48-54.   Published online January 15, 2005
Purpose : The pathologic mechanisms of central nervous system(CNS) injuries in human meningitis are not yet completely understood. Recent studies indicate that the host inflammatory responses are as important in brain damage as the infecting organisms and toxins. There have been some reports on the relationship of nitric oxide(NO), macrophage inflammatory protein-1α(MIP-1α), and lactoferrin in bacterial meningitis, but few reports...
Epidemiologic Study of Aseptic Meningitis in Daejeon, Korea(1987 through 2003)
Jung-Hoon You, Kyung-Yil Lee, Hyung-Shin Lee, Ja-Hyun Hong, Mi-Hee Lee, Byung-Chul Lee
Clin Exp Pediatr. 2004;47(11):1181-1185.   Published online November 15, 2004
Purpose : To evaluate the epidemiologic characteristics of aseptic meningitis in Daejeon, Korea from 1987 to 2003. Methods : A total of 2201 medical records of children with aseptic meningitis admitted to the Catholic University of Korea, Daejeon St. Mary's Hospital, was retrospectively analyzed. Results : The mean annual number of cases was 129, with a higher rate of occurrence in the...
Is Acute Nonspecific Mesenteric Lymphadenitis Associated with Acute Abdominal Pain in Epidemic Aseptic Meningitis?
Hae Rim Kim, Kiyoung Ku, Young Hwan Lee, Sin Kam, Jin-Bok Hwang
Clin Exp Pediatr. 2004;47(6):623-627.   Published online June 15, 2004
Purpose : Acute abdominal pain in an epidemic aseptic meningitis which is mostly an enterovirus as causative agent, is noted in 23-55% of patients. An enterovirus is also known as one of the causes of acute nonspecific mesenteric lymphadenitis(ANML). The purpose of this study was to see if ANML was associated with acute abdominal pain in epidemic aseptic meningitis. Methods :...
Aseptic Meningitis Secondary to High-Dose Intravenous Immunoglobulin Therapy in Kawasaki Disease
Ae Ra Cho, Jee Yoon Park, Kyung Hyo Kim, Young Mi Hong
Clin Exp Pediatr. 2004;47(5):561-566.   Published online May 15, 2004
Purpose : Kawasaki disease is a multisystemic inflammatory vasculitis and associated with neurologic features such as aseptic meningitis. High-dose intravenous immunoglobulin(IVIG) is used to treat Kawasaki disease and generally considered to be safe, but rare cases of aseptic meningitis with unknown etiology have been reported. The aseptic meningitis associated with Kawasaki disease was compared with meningitis as the adverse reaction...
Interpretation of Traumatic Lumbar Puncture in Aseptic Meningitis
Su Jin Sung, Jung Kim
Clin Exp Pediatr. 2004;47(5):543-546.   Published online May 15, 2004
Purpose : This study was undertaken to find out a useful method that can predict the true leukocytosis in blood-contaminated cerebrospinal fluid(CSF) due to traumatic lumbar puncture(LP), using white and red cell counts of sanguineous CSF and peripheral blood. Methods : From May 2001 to December 2002, among 1,247 patients presenting symptoms of meningitis who had received LP at Chonnam Hospital,...
Clinical and Virologic Study of Aseptic Meningitis
Hyun Ji Kim, Hae Kwan Cheong, Cheoll Jung, Kyu Man Lee, Young Mee Jee, Won Duck Kim, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi
Clin Exp Pediatr. 2004;47(4):392-398.   Published online April 15, 2004
Purpose : The cause of aseptic meningitis remains mostly unknown because viral culture and identification is difficult. Thus, we report a study on 123 children with aseptic meningitis in Gyeongju in 2002 to identify the causing virus and the relationship with the clinical manifestation. Methods : We prospectively investigated the patients, admitted to Dongguk University Hospital, into two groups between April...
A Clinical Study of Aseptic Meningitis in the Busan Area in 2002
Ji Hyun Park, Na Young Lee, Gil Hyun Kim, Jin Hwa Jung, Kyung Soon Cho, Sung Mi Kim
Clin Exp Pediatr. 2003;46(9):858-864.   Published online September 15, 2003
Purpose : There was a outbreak of aseptic meningitis in Busan, 2002. We report the clinical features and causative viruses. Methods : Two hundred seventy six children with aseptic meningitis who were admitted to the Department of Pediatrics, Maryknoll Hospital between January and December, 2002 were included. CSF, stool and throat swab viral cultures were done in 244 of these...
Case Report
A Case of Aseptic Meningitis Following Administration of Intravenous Immunoglobulin in A Patient with Idiopathic Thrombocytopenic Purpura
Su Jin Kim, Ji Eun Kim, Hei Won Hwang, Ji Sun Mok, Dong Seok Lee, Doo Kwun Kim, Sung Min Choi, Woo Taek Kim
Clin Exp Pediatr. 2001;44(7):823-826.   Published online July 15, 2001
Intravenous immunoglobulin(IVIG) has been widely used to treat idiopathic thrombocytopenic purpura in childhood. Aseptic meningitis has been reported as a rare complication of IVIG therapy. This report is on an 11 year-old boy with ITP who suffered from aseptic meningitis following the administration of IVIG. He was given 1 g/kg of IVIG for 2 days, and on the fourth day...
Original Article
Changes of Interleukin-10 and Granulocyte Colony-Stimulating Factor in Cerebrospinal Fluid of Children with Aseptic Meningitis
Byeong Chan Park, Jung-Yeon Shim, Jeong Mi Lee, Jin-Young Park, Myung Ja Yoon, Hye Rim Jung, Moon Soo Park, Dong Hyeuk Keum, Dong Keug Keum
Clin Exp Pediatr. 1999;42(12):1676-1682.   Published online December 15, 1999
Purpose : Interleukin(IL)-10 is an antiinflammatory cytokine produced by monocytes/macrophages. Granulocyte colony-stimulating factor(G-CSF) plays an important role, not only as a hemopoietic factor but also as a regulating factor for a biologic defense system by neutrophils, in the foci of infection. We studied G-CSF and IL-10 levels in the serum and cerebrospinal fluid(CSF) of patients with aseptic meningitis and investigated...
Clinical Study of Aseptic Meningitis from 1996 to 1998 in Chounju Presbyterian Medical Center, Korea
Seung Woo Paik, Byoung Lae O, Sun Ja Cho, Young Taek Chang
Clin Exp Pediatr. 1999;42(6):765-770.   Published online June 15, 1999
Purpose : There was an explosive prevalence of aseptic meningitis for three years from 1996 to 1998. In this study, we reported the time of outbreak, clinical manifestation, CSF examination of patient, and CSF virus culture. Methods : We reviewed clinical records of 794 aseptic meningitis patient who had been admitted to Chounju Presbyterian Medical Center. The total number of patients...
Clinical Studies of Aseptic Meningitis in Pusan Area in 1996
Ji Yeon Hur, Tag Soo Kim, Woo Je Cho, Sung Won Kim
Clin Exp Pediatr. 1998;41(1):38-46.   Published online January 15, 1998
Purpose : We report clinical features and viral studies on 153 children with aseptic meningitis in the Pusan area in 1996 and compare the results of this study with those of other reports in 1990 and 1993. Methods : One hundred fiffy-three children with aseptic meningitis who have been admitted to the Department of Pediatrics, St. Benedict Hospital between July and October 1996 were...
An Epidemic of Aseptic Meningitis in Summer 1996 and Global Analysis and Comparision of It with 1993
Jung Ah Chung, Young Jun Kim, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1997;40(8):1081-1090.   Published online August 15, 1997
Purpose : In the Summer 1996, there was an outbreak of aseptic meningitis without sequele. 116 cases who were admitted to our Department during a six month period from May to October, 1996. Therefore, we report epidemic of aseptic meningitis in 1996 and analyze and compare it with a epidemic of aseptic meningitis in 1993. Methods : We studies about clinical manefestation and laboratory finding...
Report of Nationwide Epidemiology of Aseptic Meningitis Outbreak in 1993 in Korea
Sung Hee Oh, Moo-Song Lee, Jin Han Kang, Chang Hwi Kim, Chong Young Park, Young Mo Sohn, Hoan Jong Lee, Chung Sik Chun, Sang Mann Shin
Clin Exp Pediatr. 1996;39(1):42-52.   Published online January 15, 1996
Purpose : There has been no nationwide report pertaining to the epidemiology of aseptic meningitis, although a great numer of patients have been diagnosed of the illness. Therefore, we report an explosive outbreak of aseptic meningitis occured in a nationwide scale in 1993. Methods : Aseptic meningitis epidemiology surveillence was performed retrospectively on the patients diagnosed of aseptic meinigitis from January...
Epidemic Aseptic Meningitis in 1993 -Focused on Virus Culture-
Ji Yeon Cho, Hyang Ju Kim, Ghee Young Jung, Jin Keun Pang, Du Bong Lee
Clin Exp Pediatr. 1995;38(7):901-906.   Published online July 15, 1995
Purpose : Aseptic meningitis is relatively common disease caused by virus, however in most of casesthe main causes are unnoticed since virus culture and isolation is quiet difficult in our country. Authors of this thesis have conducted virus culture and isolation test to figure out cause of aseptic meningitis that was prevalent through out the country from June to July...
A Clinical Observation of Kawasaki Meningitis and Viral Meningitis
Jae-Ho Hyun, Young-Hoon Kim, Ji-Whan Han, Jong-Wan Kim, Kyung-Tai Whang
Clin Exp Pediatr. 1995;38(6):794-803.   Published online June 15, 1995
Purpose : This study was performed to investigate the clinical characteristics in Kawasaki meningitis and viral meningitis. Methods : A clinical observation and comparison were carried out on 37 patients of Kawasaki disease with meningitis(group A) and 28 patients of Kawasaki disease without meningitis (group B) who were admitted to Catholic Medical Center from July, 1991 to June, 1993 and 100...
Changes of Interleukin-6 Level in Serum and CSF in Aseptic Meningitis
Moon Kyu Kim, Dong Soo Kim
Clin Exp Pediatr. 1995;38(5):625-632.   Published online May 15, 1995
Purpose : Aseptic meningitis is an infection of CNS caused by virus and there are remarka-ble changes in endogenous cytokine level. Interleukin-6 is a pleiotropic and multi-functional cyt-okine and plays a central role in host defense mechanisms. We studied the IL--6 level in serum and CSF with the patients of aseptic meningitis and investigated the relationship of IL-6 with C...
The Variations of CSF Glucose-To-Blood Glucose Ratio according to the Time of Blood Sampling in Asepetic Meningitis
Dong Gui Jang, Yong Seok Choi, Mee Kyoung Lee, Chang Hee Kim, Dong Jin Lee
Clin Exp Pediatr. 1994;37(12):1687-1692.   Published online December 15, 1994
The Measurement of CSF glucose and CSF glucose-to-blood glucose ratio is a very useful laboratory test for the differential diagnosis of meningitis. We have observed the change of blood glucose & CSF glucose-to-blood glucose ratio according to the time of blood sampling in 84 patients with aseptic meningitis who had been admitted to the department of peditrics, Dong Kang hospital...
Clinical and Epidemic Studies of Aseptic Meningitis
Dong Yoon Kim, Koo Pong Jung, Heung Keun Oh, Chang Ok Soh, Jin Young Jung
Clin Exp Pediatr. 1994;37(10):1420-1426.   Published online October 15, 1994
Detection of Enterovirus in Patients with Aseptic Meningitis by Reverse Transcription and Polymerase Chain Reaction
Souck Joong Yoon, Sung Jin Hong, Young Hyuk Lee, Min Hee Kim, Kyo Sun Kim, Kyu Hyun Park, Jae Myun Lee, Won Young Lee
Clin Exp Pediatr. 1994;37(9):1226-1234.   Published online September 15, 1994
The aim of this study was to determine the applicability of reverse transcription and polymerase chain reaction(RT/PCR) for routine diagnostic use and for the detection of enteroviral mentigitis, Primers were selected in the highly conserved part of the 5'-non-coding region of the enteroviral genome. Enteroviral RNA was detected by the RT/PCR in routinely collected cerebrospinal fluids(CSF) of patients with aseptic...
Case Report
A Case of Cerebral Infarction and Subdural Hemorrhage after Aseptic Meningitis
Hyun Mi Kim, Si Whan Koh, Kyung Hwan Oh, Young Chang Kim, Sang Joo Lee
Clin Exp Pediatr. 1994;37(5):707-711.   Published online May 15, 1994
After aseptic or septic meningitis, some neurologic complications such as convulsions, delirium, rigidity, cerebral infarctions and cerebral hemorrhage can be developed. The cerebral infarction after meningitis is caused by arterial or venous occlusions. Involvement of small perforating arteries leads to ganglionic infarcts while severe sapsm of major vessels may lead to massive infarctions in the distribution of middle and/or anterior...
Original Article
Hand, Foot and Mouth Disease Associated with the Aseptic Meningitis in Seoul, 1990
Young Ah Lee, Sei Ho Oh, Soo Jong Hong, Young Hwue Kim, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1993;36(6):842-849.   Published online June 15, 1993
We performed clinical and virological studies on 79 children with hand, foot and mouth disease(HFMD) who had been admitted or visited to the department of Pediatrics, Asan Medical Center from February to August, 1990. The results were as follows; 1) There were total of 79 cases with hand, foot and mouth disease during this period. The aseptic meningitis was combined in 18cases(22.8%) 2)...
Clinical Observation of Aseptic Meningitis Associated with Mucocutaneous Lymph Node Syndrome
Jae Hee Han, Seon Jin Ji, Mee Kyung Namgoong, Hae Yong Lee, Jae Seung Yang, Baek Keun Lim
Clin Exp Pediatr. 1993;36(6):805-809.   Published online June 15, 1993
Clinical observation was carried out for 147 patients with mucocutaneous lymph node syndrome(MCLS) who were admitted to the Department of Pediatrics, Wonju Cristian Hospital during the period from June, 1983 to June, 1992. A spinal tap was performed on 114 of these patients and the following results were obtained. 1) The incidence of aspetic meningitis in patients with MCLS was 52.6%.(60...
Aseptic Meningitis in 1991 - isolation of causative agent -
Yoon Ah Park, Eun Young Cho, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1993;36(4):506-511.   Published online April 15, 1993
To know the causative agent of asptic meningitis, we performed blood and cerebrospinal fluid study on 24 children who had been admitted to the department of Pediatrics, Asan Medical Reference Laboratory, Japan. The most of the patients were young infants, and 15 cases of them were under 3 months of age. The male to female ratio was 1:1.4. We observed the main symptoms...
A Clinical Study on Aseptic Meningitis Combined with Polio-Like Paralysis
Woong Young Moon, Ki Soo Kim, Young Seo Park, Hyung Nam Moon, Chang Yee Hong, Dae Chul Suh, Si Joon Yu, In Young Seong, Young Min Ahn
Clin Exp Pediatr. 1993;36(4):485-494.   Published online April 15, 1993
We clinically reviewed four patients who were suffering from aseptic meningitis combined with polio-like paralysis and performed radiological, neurological and virological studies on them. Three patients were admitted to the department of Pediatrics. Asan Medical Center from March to August 1990, and one patient was admitted to the department of Pediatrics, Kangnam General Hospital. The results were as follows: 1) During the period...
Epidemics of aseptic meningitis in Seoul area during 1989-90.
Eun young Cho, Mi Koo Kang, Soo Jong Hong, Ki Soo Kim, Young Seo Park, In Sook Park, Hyung Nam Moon, Chang Yee Hong
Clin Exp Pediatr. 1991;34(11):1565-1572.   Published online November 30, 1991
We performed clinical and virological studies on 200 children with aseptic meningitis who had been admitted to the department of Pediatrics, Asan Medical Center from June, 1989 to August, 1990. The results were as follows; 1) There were total of 236 meningitis cases during this period, 13(5.5%) with bacterial meningitis, 3(1%) with tuberculous meningitis, 220(93.2%) with aseptic meningitis. Am이lg aseptic meningitis, 20(8.5%) were mumps meningitis. 2) Aseptic meningitis...
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