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Original Article
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Risk factors and screening timing for developmental dysplasia of the hip in preterm infants
Ga Won Jeon, Hye Jung Choo, Yong Uk Kwon
Clin Exp Pediatr. 2022;65(5):262-268.   Published online November 5, 2021
Question: When is the best screening timing and what is the risk factor for developmental dysplasia of the hip (DDH) in preterm infants?
Finding: Ultrasonography performed earlier than 38 weeks of postmenstrual age caused unnecessary subsequent ultrasonography. DDH did not occur predominantly on the left side or in breech infants.
Meaning: The screening timing, etiology, and risk factors for DDH in preterm infants are somewhat different from those in term infants.
Case Report
Candida tropicalis arthritis of the elbow in a patient with Ewing's sarcoma that successfully responded to itraconazole
Seung Youn Kim, Jung Sub Lim, Dong Hwan Kim, Hyeon Jeong Lee, Joong Bum Cho, Jun Ah Lee, Dong Ho Kim
Clin Exp Pediatr. 2011;54(9):385-388.   Published online September 30, 2011

Fungal infections are rarely responsible for arthritis. Few cases of fungal arthritis have been reported, even in immunocompromised hosts susceptible to low-virulence organisms. Herein, the authors report the first case of Candida tropicalis arthritis in a child with a solid tumor. A 13-year-old boy with Ewing's sarcoma developed arthritis in his elbow during the neutropenic period after chemotherapy. Despite treatment...

A case of reactive arthritis after Salmonella enteritis in in a 12-year-old boy
Peter Chun, Young Jin Kim, Young Mi Han, Young Mi Kim
Clin Exp Pediatr. 2011;54(7):313-315.   Published online July 31, 2011

Reactive arthritis comprises a subgroup within infection-associated arthritides in genetically susceptible hosts. Researchers and clinicians recognize two clinical forms of reactive arthritis which occurs after genitourinary tract infection and after gastrointestinal tract infection. Chlamydia infection has been implicated as the most common agent associated with post-venereal reactive arthritis. Studies have proposed Shigella infection, Salmonella infection, or Yersinia infection as the...

Review Article
Treatment of juvenile rheumatoid arthritis
Kwang Nam Kim
Clin Exp Pediatr. 2010;53(11):936-941.   Published online November 30, 2010

The systematic approach to pharmacologic treatment is typically to begin with the safest, simplest, and most conservative measures. It has been realized that the more rapidly inflammation is under control, the less likely it is that there will be permanent sequelae. Nonsteroidal anti-inflammatory drugs (NSAIDs) are the mainstay of initial treatment for inflammation. In addition, the slow-acting antirheumatic drugs (SAARDs)...

Juvenile idiopathic arthritis: Diagnosis and differential diagnosis
Ki Hwan Kim, Dong Soo Kim
Clin Exp Pediatr. 2010;53(11):931-935.   Published online November 30, 2010

Juvenile idiopathic arthritis (JIA) is comprised of a heterogeneous group of several disease subtypes that are characterized by the onset of arthritis before the age of 16 years and has symptoms lasting at least 6 weeks. The previous classification of JIA included seven different categories, whereas its current classification was compiled by the International League of the Association for Rheumatology,...

Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis
Youn-Soo Hahn, Joong-Gon Kim
Clin Exp Pediatr. 2010;53(11):921-930.   Published online November 30, 2010

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve...

Case Report
A case of postoperative nasopharyngeal reflux associated with retropharyngeal lymphangioma in newborn infant
Ah Reum Kwon, Eun Jung Park, Ki Hwan Kim, Dong Soo Kim
Clin Exp Pediatr. 2010;53(2):262-266.   Published online February 15, 2010
Tumor necrosis factor-α (TNF-α) is a major proinflammatory cytokine involved in the pathophysiology of juvenile rheumatoid arthritis. Etanercept is an effective inhibitor of TNF-α and has shown a beneficial effect in patients with JRA. However, the most important cause of concern related to etanercept administration is infection. We report a case of encephalitis in a JRA patient receiving long-term treatment...
Review Article
Juvenile rheumatoid arthritis
Dong Soo Kim
Clin Exp Pediatr. 2007;50(12):1173-1179.   Published online December 15, 2007
The diagnosis of juvenile rheumatoid arthritis (JRA) is based on patient's age at disease onset, symptom duration, gender, and clinical manifestations. JRA is of unknown origin, begins under the age of 16, and persists for a minimum of 6 weeks. JRA is categorized into three principal types, systemic, oligoarticular and polyarticular. Infection, other connective tissue diseases, malignancy, trauma, and immunodeficiency...
Original Article
Clinical observations of juvenile rheumatoid arthritis
Joo Hoon Lee, Jeong Min Ryu, Young Seo Park
Clin Exp Pediatr. 2006;49(4):424-430.   Published online April 15, 2006
Purpose : Juvenile rheumatoid arthritis(JRA) is one of the most common rheumatic diseases of childhood and is an important cause of short- and long-term disability. The purpose of this study was to determine the disease course and outcome in childhood patients with JRA. Methods : Fifty nine patients with JRA who were diagnosed and treated in the Department of Pediatrics, Asan...
Clinical Features of Septic Arthritis in Neonates
Min Jung Kwak, Su Eun Park
Clin Exp Pediatr. 2004;47(11):1161-1166.   Published online November 15, 2004
Purpose : Septic arthritis is uncommon in neonates, and the diagnosis of septic arthritis in newborns is difficult because of non-specific laboratory findings and paucity of signs and symptoms. When appropriate treatment is delayed, permanant sequelae are inevitable. We report a retrospective study of 22 neonates who were diagnosed with septic arthritis. Methods : We reviewed 22 patients, who were diagnosed...
Effect of Histone H1 on Collagen Induced Arthritis in Mice
Jae Ho Yang, Kyung Mi Shin, Dong Soo Kim
Clin Exp Pediatr. 2004;47(7):779-788.   Published online July 15, 2004
Objective : Besides the functions of histones in the nucleus of the cells, there is growing evidence that histones have many other extra-cellular or extra-nuclear functions, such as stabilizing axonemal microtubule of sea urchin sperm flagella. This microtule assembly function of the histone is similar to that of taxol, which has an effect of controlling joint inflammation. In this study,...
Effect of a Flavon Extracted from Artemisia absinthium on Collagen Induced Arthritis in Mice
Kyong Min Choi, Dae Hwan Hwang, Kyung Mi Shin, Do-Young Yoon, Dong Soo Kim
Clin Exp Pediatr. 2004;47(6):677-684.   Published online June 15, 2004
Purpose : In this study, a possible suppressive effect of a flavon extracted from Artemisia absinthium on a mouse collagen-induced arthritis (CIA) model was investigated. Methods : DBA/1 mice were injected intradermally with emulsified chicken type II collagen. Three weeks after immunization, a flavon was introduced p.o. everyday. Clinical incidences of arthritis and arthritis index were measured. Measurement of anti-collagen antibodies...
Case Report
A Case of Multiple Septic Arthritis by Streptococcus pneumoniae in Kawasaki Disease
Jae-Hoon Choe, In-Gyu Lee, Kyung-Bae Park, Joon-Soo Park, Young Chang Kim, Hwa-Yong Song, Byung-Heum Kim
Clin Exp Pediatr. 2004;47(5):579-582.   Published online May 15, 2004
In Kawasaki disease, arthritis may occur, generally affecting the hands, knees, ankles, or hips. Operations have not usually been needed. We report a case of Kawasaki Disease with multiple septic arthritis which was caused by S. pneumoniae and which needed athrotomy with drainage for both hips, both knees, and both ankle joints. A two year, ten-month-old girl was admitted to...
Arthritis in the Subacute Stage of Kawasaki Disease after Responding to Intravenous Immunoglobulin Treatment
Kyung-Yil Lee, Jin-Hee Oh, Dea-Kyun Koh
Clin Exp Pediatr. 2003;46(11):1124-1127.   Published online November 15, 2003
We evaluated the clinical and laboratory characteristics of five children with Kawasaki disease who had showed arthritis after responding to intravenous immunoglobulin(IVIG) treatment. Age distribution was between 13 months and six years of age(mean 3.2?.6 years). There were two males and three females. Arthritis occurred when acute symptoms were subsiding, with the average onset on day 5.8?.8 after final IVIG...
Original Article
Etiologic Agents and Clinical Features of Acute Pyogenic Osteoarthritis in Children
Young Ho Kwak, Su Eun Park, Jung Youn Hong, He Sun Jung, Jin Young Park, Jung Hwan Choi, Hoan Jong Lee, In Ho Choi
Clin Exp Pediatr. 2000;43(4):506-513.   Published online April 15, 2000
Purpose : Though acute pyogenic infections of musculoskeletal system are infrequent in children, delayed diagnosis or inadequate management may cause serious chronic sequelae. We analysed 40 cases of children who were affected by acute septic osteomyelitis and/or septic arthritis to find etiologic agents and to establish proper initial antimicrobial therapy. Methods : Medical records of 40 cases of microbiologically confirmed acute...
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