Clinical and Experimental Pediatrics

Original Article

Nephrology (Genitourinary)

Impaired angiogenesis in the enalapril-treated neonatal rat kidney

Hyung Eun Yim, Kee Hwan Yoo, Eun Soo Bae, Young Sook Hong, Joo Won Lee

Clin Exp Pediatr. 2016;59(1):8-15. Published online January 22, 2016

Purpose

Nephrogenesis is normally accompanied by a tightly regulated and efficient vascularization. We investigated the effect of angiotensin II inhibition on angiogenesis in the developing rat kidney.

Methods

Newborn rat pups were treated with enalapril (30 mg/kg/day) or vehicle (control) for 7 days after birth. Renal histological changes were checked using Hematoxylin & Eosin staining. We also investigated the intrarenal expression of vascular...

DOI: https://doi.org/10.3345/kjp.2016.59.1.8

Effect of angiotensin II inhibition on the epithelial to mesenchymal transition in developing rat kidney

Hyung Eun Yim, Kee Hwan Yoo, In Sun Bae, Young Sook Hong, Joo Won Lee

Clin Exp Pediatr. 2009;52(8):944-952. Published online August 15, 2009

Purpose:To investigate the effects of angiotensin II inhibition on the epithelial to mesenchymal transition (EMT) in the developing kidney, we tested the expression of EMT markers and nestin in angiotensin converting enzyme (ACE) inhibitor-treated kidneys. Methods:Newborn rat pups were treated with enalapril (30 mg/kg/d) or a vehicle for 7 days. Immunohistochemistry for the expression of α-smooth muscle actin (SMA), E-cadherin, vimentin, and nestin were...

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Phenotypic Transformation of Tubular Epithelial Cells and Fibroblasts Following Unilateral Ureteral Obstruction or Angiotensin II Infusion in the S-D Rat

Eui Seong Lee, Min Jee Jeoung, Kee Hwan Yoo, Young Sook Hong, Joo Won Lee, Soon Kyum Kim

Clin Exp Pediatr. 2004;47(4):430-438. Published online April 15, 2004

Purpose : Unilateral ureteral obstruction(UUO), a well established experimental model of renal injury, gives rise to tubulointerstitial fibrosis, tubular dilatation and cellular atrophy. Angiotensin(ANG) II may take the prime role in the regulation of this response. The objectives in the current investigation were to determine whether the renal response to UUO involves the dedifferentiation of tubular epithelial cells to mesenchymal...

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Case Report

Angiotensin Converting Enzyme Inhibition Modulates Mitogen Activated Protein Kinase Family Expressions in the Neonatal Rat Kidney

Byung Min Choi, Mee-Hye Oh, Kee Hwan Yoo

Clin Exp Pediatr. 2004;47(3):325-331. Published online March 15, 2004

Purpose : In a developing kidney, the renin-angiotensin system(RAS) is markedly activated and is thought to play an important role in postnatal renal growth and maturation. We previously demonstrated that angiotensin converting enzyme(ACE) inhibition in a developing rat kidney increases apoptosis and decreases its related gene expressions, which may account for renal growth impairment. Among the mitogen-activated protein kinases(MAPK) family...

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