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Original Article

Hematology

Effects of α-tocopherol on hemolysis and oxidative stress markers on red blood cells in β-thalassemia major

Nora Sovira, Munar Lubis, Pustika Amalia Wahidiyat, Franciscus D. Suyatna, Djajadiman Gatot, Saptawati Bardosono, Mohammad Sadikin

Clin Exp Pediatr. 2020;63(8):314-320. Published online August 15, 2020

Web of Science 10 Crossref 9

Question: Is the α-tocopherol as an exogenous antioxidant supplementation effective in improving hemolysis and oxidative stress on β-thalassemia major?
Finding: We found significant enhancements in plasma haptoglobin were noted in the α-tocopherol group (3.01 mg/dL; range, 0.60–42.42 mg/dL; P=0.021).
Meaning: The α-tocopherol can improve hemolysis by increasing the haptoglobin level as hemolysis marker.

DOI: https://doi.org/10.3345/cep.2019.00542

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