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Original Article
Specific Antibody Response in House Dust Mite Asthmatics on Immunotherapy.
Won Sup Shin, Bub Sung Kim, Sang Il Lee
Clin Exp Pediatr. 1989;32(9):1282-1287.   Published online September 30, 1989
The immunotherapy has become a useful and effective method to treat allergic respiratory diseases. It is a logical assumption that immunotherapy produces symptom relief as a result of immunologically specific response. This study was performed to delineate the IgE, IgG and IgG4 responses to immunotherapy, and their relationships. We selected the six asthmatic children on immunotherapy with Dermatophagoides pteronyssinus (Dp). A set of samples from each...
Effect of Oxandrolone Therapy in Short Stature.
Yil Sub Lee, Soo Young Lee, Duk Hi Kim
Clin Exp Pediatr. 1989;32(9):1273-1281.   Published online September 30, 1989
Fifty six boys and 28 girls aged 4 to 15.8 years were treated with oxandrolone during the 4 to 25 months. Measurement of height and bone age were made at the beginning and at 6 months intervals. The daily dose were 0.08 mg to 0.28 mg per kilogram. Predictions for adult height at the beginning of the study were compared with those at...
Methylprednisolone Pulse Therapy in Childhood Nephropathies.
Moon A Kim, Pyung Kil Kim
Clin Exp Pediatr. 1989;32(9):1259-1264.   Published online September 30, 1989
Methylprednisolone “pulse” therapy was performed on 22 patients of childhood nephropathies who showed resistance to conventional therapy. The diseases included steroid-resistant or frequent relaps- ing nephrotic syndrome including minimal change nephrotic syndrome, focal segmental glomer- ulosclerosis, membranous nephropathy, mesangioproliferative glomerulonephritis, Henoch-Schonlein purpura nephritis and SLE nephritis. Methylprednisolone 30 mg/kg/day was administered intravenously over one hour, which was repeated 6 times on every other day. Sixteen of...
A Case of Hypereosinophilic Syndrome.
Byoung Hoon Lee, Jae Wook Ko, Soon Wha Kim, Don Hee Ahn
Clin Exp Pediatr. 1989;32(4):561-566.   Published online April 30, 1989
Hypereosinophilic syndrome is a state of severe eosinophilia of unknown cause accomanied by multiple organ-system involvement. The criteria of hypereosinophilic syndrome includes. (1) A persistent eosinophil count of more than 1.5 X 10 9 /L for associated with the signs and symptoms of hypereosinohilic disease; (2) a lack of evidence for parasite, allergic, or other known causes of eosinophila; (3) presumptive signs and...
Treatment of Acute Myelogenous Leukemia in Children: Remission Induction with Adriamycin and Cytosine Arabinoside, and Postremission Maintenance Chemotherapy with Adriamycin, Cytosine Arabinoside and 6-thioguanine.
Soon Ki Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):850-862.   Published online July 31, 1988
The authers assessed the effectiveness of chemotherapy in 40 children with AML, experienced at Seoul National University Children’s Hospital during 8 years 5 months from April 1979 to August 1987. Remission induction treatment included adriamycin 30 mg/m2/day IV on days 1-3 and cytosine arabinoside 75 mg/m2/day continuous IV infusion on days 1-5. This regimen was repeated, if necessary, for one or two more courses. After...
Clinical Characteristics and Pathogenesis of Typhlitis in Childhood Non-Lymphocytic Leukemia-Considerations on Clinical Mangement with Report of Two Cases and Literature Review.
Do Hyun Kim, Sung Oh Kim, Soo Yup Lee, In Joon Seol, Hahng Lee, Chong Moo Park, Poong Man Jung, Seok Chol Jeon, Young Hyeh Ko, Jung Dal Lee
Clin Exp Pediatr. 1988;31(5):607-620.   Published online May 31, 1988
The treatment of acute leukemia in childhood has been increasingly successful due to progression of chemotherapeutics and other supportive care. Improved survival rates in acute childhood leukemia have been associated with an increasing number of complications in the gastrointestinal tract. Typhlitis also known as ileocecal syndrome is a necrotizing inflammation of the cecum in leukemic patients on chemotherapy in the terminal stage of the...
Clinical Study on Growth Hormone Deficient Dwarfs.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(5):597-606.   Published online May 31, 1988
34 patients with growth hormone (GH) deficiency were studied. The affected males outnumber females in a proportion of 1.8 to 1. The chronological ages on diagnosis was average 9.4 years old and bone age was delayed with average 6.6 years old. The major cause of GH deficiency was idiopathic and organic causes such as craniopharyngioma, germinoma & Tb. meningitis were relatively uncommon. Cerebral anoxia seemed...
2 Cases of Infantile Spasms(Cryptogenic Type) Treated with ACTH Therapy.
Shin Heh Kang, Chang Jun Coe
Clin Exp Pediatr. 1987;30(8):928-933.   Published online August 31, 1987
We have experienced 2 cases of infantile spasms treated with ACTH. They were diagnosed as cryptogenic type within relatively short duration after the onset. With the administration of ACTH, flexor spasms and hypsarrhythmia disappeared. They did not demonstrate any intellectual impair- ment on OPD follow up study. A brief review of literatures was made.
Heparin Therapy for Disseminated Intravascular Coagulation in Childhood.
Byung Ryul Choi, Yong Hoon Park, Jeong Ok Hah
Clin Exp Pediatr. 1987;30(6):658-663.   Published online June 30, 1987
A clinical trial for the therapeutic effect of heparin on DIC was conducted on 22 patients of DIC who were admitted to the pediatric department of Yeungnam University Hospital from September 1, 1984 to May 31, 1986. In addition to the conservative treatment, intensive care of underlying disease and specific replacement therapy for DIC, heparin was administered to the one-half of the patients...
The Evaluation for the Immunotherapy to Bronchial Asthmatics.
Jung Woo Shin
Clin Exp Pediatr. 1987;30(3):247-252.   Published online March 31, 1987
The changes of skin-test reactivities, total and specific serum IgE levels, and peripheral eosinophil counts were observed periodically in 20 bronchial asthmatics. The immunotherapy was performed with the Specific desensitization Vaccine(Bencard), i. e. mixture of multiple allergens specific for each patients, and scheduled reach the maintenance doses within 6 months. The skin-test reactivity index, i. e. the ratio of the average diameter of the wheal...
Case Report
Hodgkin’s Disease in Children
Soo Jong Hong, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1986;29(12):1352-1359.   Published online December 31, 1986
Twenty one cases of Hodgkin’s disease under 15 years of age who were admitted to Dept, of Ped. of Seoul National University Hospital from Jan. 1976 to Dec. 1985 were reviewed and analysed. One hundred and five cases of non-Hodgkin’s lymphoma were seen during the same period. 1) The ratio of non-Hodgkin’s lymphoma to Hodgkin's disease was 5:1. 2) The age ranged from 18/12 years...
Original Article
Effects of Phototherapy on Peripheral Blood Findings in Full Term Newborns.
Moon Ja Kim, Keun Lee
Clin Exp Pediatr. 1986;29(7):710-714.   Published online July 31, 1986
The effects of phototherapy used in treatment of neonatal hyperbilirubinemia on peripheral blood findings were studied in full term newborns. There was no significant difference between daily mean hematocrits and WBC counts of phototherapy group and control group. The mean platelet count was not decreased during phototherapy in treated group, but significantly increased after phototherapy was stopped. 、
Clinico-pathologic Study Glumerulonephritis with Crescents in 25% or more of Glomeruli in Children.
Hoan Jong Lee, Kwang Wook Ko
Clin Exp Pediatr. 1985;28(4):353-371.   Published online April 30, 1985
We experienced 17 pediatric patients of glomerulonephritis with crescents in 25% or more of glomeruli, who were admitted to Department of Pediatrics, Seoul National University Hospital, from Jan. ’79 to Dec. ’84. A review of clinical and pathologic findings revealed as follows; 1)The 17 patients were 10 cases of Henoch-Schdnlein nephritis, 3 cases of idiopathic nephrotic syndrome which were due...
Clinical Obsertation and Treatment in Child Shigellosis.
C S Sohn, I S Lee, E H Cho, K B Kim
Clin Exp Pediatr. 1984;27(12):1168-1175.   Published online December 31, 1984
Clinical Observation and Treatment in Child Shigellosis C.S. Sohn, M.D., I.S. Lee, M.D., E.H. Cho, M.D. and K.B. Kim, M.D. Dspartmznt of Pediatrics, Kwangju Christian Hospital，Korea On 51 cases of infants and children who .had been bacterologically diagnosed as shigellosis and treated with various regimens from March, 1980 to August, 1983 in Kwang-ju Christian Hospital observations were made as to the clinical manifestation and to...
The Influence of Phototherapy on the Concentration of Serum Calcium.
Hyun Sook Lee, Hung Bae Park
Clin Exp Pediatr. 1984;27(9):865-871.   Published online September 30, 1984
Since the report of Dr. Cremer in the 1950s the effectiveness of phototherapy in the treatment of neonatal hyperbilirubinemia has been demonstrated in many clinical trials and now become widely accepted as a routine therapeutic measure in most pediatric clinics. Considering the relatively high incidence of prematurity and neonatal jaundice especially in Asian countries, it is of great concern to...
Case Report
Rifampin Induced Nonresponsiveness to Steroid Therapy in Children with Minimal Change Nephrotic Syndrome .
Hae Il Cheong, Sang Bok Suk, Yong Choi, Kwang Wook Ko
Clin Exp Pediatr. 1984;27(5):506-510.   Published online May 31, 1984
We experienced three children with the biopsy proven minimal change nephrotic syndrome who had failed to respond to prednisolone, 60 mg/m2/d for 4 to 9 weeks due to concomittent administration of rifampin. Because rifampin is a known enzyme inducer of the liver like phenobarbital and dilantin which can increase the clearance of the other drugs such as steroid etc., rifampin were...
Original Article
A Clinical Study of Histiocytosis in Childhood.
Hee Jung Chung, Byung Soo Kim, Chan Il Park
Clin Exp Pediatr. 1984;27(3):253-264.   Published online March 31, 1984
A clinical study with particular emphasis on the result of chemotherapy has been made on. 34 cases of histiocytosis diagnosed at the Department of the Severance Hospital and Yonsei Cancer Center from January 1975 to December 1981. The results may be summarized as follows: 1) Among histiocytosis, HSC and LSD were each present in elevent cases, E-G in seven and HMR...
The Effect of Phototherapy in Distance between Light Source and Hyperbilirubinemic Baby.
Jae Gye Ryoo, Hong In Eum, Kyung Tae Kim, Kew Taek Kim
Clin Exp Pediatr. 1983;26(12):1173-1178.   Published online December 31, 1983
Warshaw reported radiat flux is closely related to distance between light source and patient for phototherapy. We tried to compare 30 cm distance (group A) frome light source to patient with 80 cm (group B) for effect of phototherapy. 1) Radiant flux were 4.68±0.3㎼/cm2/nm in group A phototherapy unit ard 1.49±0. 02㎼/cm2/nm in group B...
The Effect of Blue Light and White Light, Continous and Intermittent Phototherapy in the Treatment of Jaundice for the Low Birth Weight Infants.
Ki Tae Kim, Heon Kyung Lee, Woo Yeong Chung, Soon Youg Lee, Yeon Soon Kim
Clin Exp Pediatr. 1983;26(4):299-303.   Published online April 30, 1983
The effect of phototherapy was studied between blue and white lights, and continuous and intermittent regimens in the treatment of jaundice for the low birth weights at Busan Children’s Hospital from October, 1981 to March, 1982. The results were as following: 1) The duration of phototherapy necessary to reduce serum bilirubin level below 8 mg/dl were 58.9 hours with blue light, and 102.3 hours with white...
Effect of Phototherapy on Platelet Count in premature Infant.
Heung Kyu Kim, Young Kyoung Park
Clin Exp Pediatr. 1983;26(1):34-40.   Published online January 31, 1983
The effect of phototherapy on platelet counts performed on thirty premature infants weighing less than 2,300 grams and thirty fullterm infants with hyperbilirubmemia. Platelet counts were also performed on twenty nine healthy premature infants weighing less than 2,300 grams and thirty full-term infants as oontrol group. The following results were observed: 1) There was no significant difference in platelet counts during phototherapy on premature...
Phototherapy for Neonatal Hyperbilirubinemia.
Il Suck Chang, Chong Ku Yun
Clin Exp Pediatr. 1983;26(1):8-13.   Published online January 31, 1983
Daylight phototherapy group (27 newborn infant) were compared with blue light photother- apy group (43 newborn infant) in serum total bilirubin decrements with phototherapy.; study A. For the purpose of dose-response relationship, 4 group (total 60 newborn infant) were compared the effectiveness of phototherapy based on radiant reflux (study B); Group 1, 5.46±0.65 ㎼/cm2.nm(mean±SD) Group 2,4.48±0.70 ㎼/cm2. nm (mean±SD)...
Study of Bilirubin Concentration on The Neonatal Jaundice.
Seung Kwon Kim, Woo Sik Chung, Byung Do Nam, Kew Taek Kim
Clin Exp Pediatr. 1982;25(11):1089-1096.   Published online November 30, 1982
W« studied the guidelines on the serum bilirubin concentration of 15 mg% for the management of neonatal jaundice and compared the group of serum bilirubin concentration below 15 mg% ■and the group of serum bilirubin concentration above 15 mg%. 83 cased of icteric infants without any risk factors for kernicterus, ahove 12 m.g% in serum bilirubin concentration, were born at the St. Benedict hospital...
Effect of Phototherapy on the Riboflavin Status in Neonatal Hyperbilirubinemia.
Young Oak Bang
Clin Exp Pediatr. 1982;25(5):436-444.   Published online May 31, 1982
Riboflavin in unstable in light and has a maximum absorption at 450nm. A study was designed to determine whether riboflavin deficiency developed in neonate who received phototherapy with eight day light bulbs for hyperbilirubinemia and to get normal value of activity coefficient of erythrocyte glutathione reductase in neonate. Twenty-seven infants who received phototherapy were investigated. Thirth-eight normal infants without phototherapy...
Testicular Leukemia.
Young Jin Hong, Jung Yeun Choi, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1982;25(1):29-35.   Published online January 31, 1982
Leukemic infiltration of the testes has been relatively rare disease. But increased survival due to advance in the treatment of childhood leukemia has been associated with an increase in incidence of leukemic infiltration of the tests. Six of 66 male children with acute lymphocytic leukemia and 2 of 2 male children with leukemic transformation on non-Hodgkin's lymphoma, who have been...
Results of Treatment in 33 Patients with Neuroblastoma.
Hak Yong Kim, Choong Kil Chung, Duk Jin Yun, Byung Soo Kim
Clin Exp Pediatr. 1981;24(10):942-949.   Published online October 31, 1981
Neuroblastoma is a malignant neoplasm which arises from primitive sympathetic neuroblasts. It is the second most common solid tumor in young children, exceeded in incidence only by brain tumors. This tumor shows immunological features and spontaneous regression. But, in spite of recent advances in multimodality therapy survival rate has not been improved much. We reviewed 33 patients with neuroblastoma who...
Case Report
A Case of Chronic Active Hepatitis.
H J Park, H K Park, H J Chun, M J Shin, S C Kang
Clin Exp Pediatr. 1981;24(10):991-996.   Published online October 15, 1981
Chronic active hepatitis (CAH) is defined as ongoing inflammation within the liver sustained beyond the expected time of resolution. The etiology of CAH is not completely understood, but hepatitis B infection, drugs such as oxyphenisatin, isoniazid, and alpha-methyldopa, and altered immunity are considered. The most common findings are jaundice, hepatosplenomegaly, elevated serum transaminase activities, hypergammaglobulinemia, and positive "autoimmune" serologic tests,...
Original Article
Clinical Study on Idiopathic Nephrotic Syndromein Children.
Haeng Mi Kim, Chang Ho Lee, Ja Hoon Koo, Doo Hong Ahn
Clin Exp Pediatr. 1981;24(6):549-558.   Published online June 15, 1981
A clinical observation was done on 38 children with idiopathic nephrotic syndrome, who had been admitted to our pediatric department during past 3 years period, from January 1978 to September 1980. The following results were obtained: At the beginning of illness, 42% were in the age group of 3~7year, and male to female ratio was approximately 3:1 of male preponderance....
A Clinical Study of Tic Disorder in Korea.
Kang E Hong
Clin Exp Pediatr. 1981;24(3):198-208.   Published online March 15, 1981
30 patients diagnosed as having tic disorder at the Child Psychiatry clinic of Seoul National University Hospital were studied in terms of sex, age, onset, precipitating factors,characteristics of the patients and family dynamics. A short term follow up study wascarried out regarding the outcomes of the symptom and the changes in attitudes and beha-viors of patients and parents. The results...
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