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Original Article
Relationship between Bronchial Hyperresponsiveness by Methacholine Provocation and the Severity of Asthma Symptoms, Pulmonary Function and Atopy
Sang Hyug Ma, Jung Mi Lee, Byung Hag Lim, Im Ju Kang
Clin Exp Pediatr. 1995;38(2):223-231.   Published online February 15, 1995
Purpose : Bronchial asthma is a disorder that is characteized by symptoms of reversible airway obstruction and increased responsiveness of the bronchus and to quantify the degree of br onchial hyperresponsivenes can be very helpful in determing the severity of disease and the prognosis. But the Methacholine provocation test is not always easy to be performed in all patients. Thus...
Airway Resistance after Exercise Loading Test in Asthmatic Children
Ji Eun Lee, Young Mi Hong, Kyung Hee Kim
Clin Exp Pediatr. 1994;37(10):1333-1339.   Published online October 15, 1994
Exercise induced asthma(EIA) is defined as acute, reversible, usually self-immiting airway obstruction which develop after strenous exercise in patients with asthma. EIA is a bigger problem in children than adults due to more active and smaller airways which obstruct more easily when bronchospasm develops. The exercise elicited amny change in pulmonary function of asthmatic children. These change could be measured...
Eosinophil Cationic Protein in Relation to Bronchial Hyperresponsiveness in Asthmatic Children
Jin Tack Kim, Joon Sung Lee
Clin Exp Pediatr. 1993;36(12):1707-1715.   Published online December 15, 1993
The eosinophil is the major cell responsible for the inflammatory reaction in bronchial asthma. Secretion of granular components is probably of considerable importance for the inflammatory effects of the eosinophils, Eosinophil cationic protein (ECP) is the one of the secretory components of the eosinophil granule and is considered as an activation marker of eosinophil, Blood eosinophil count, serum concentration of...
Arterial Blood Gas Analysis in Asthmatic Children
Dae Young Choi, Kyeong Cheol Yoon, Kang Woo Park, Sung Won Kim
Clin Exp Pediatr. 1993;36(10):1375-1382.   Published online October 15, 1993
The purpose of this study is to verify severity of asthma in asthmatic patients through the arterial blood gas analysis. Subjects were consisted of 103 patients (74 boys and 29 girls), between 2~13 years of ages. Clinically, asthmatic patients were classified into 6 groups, i.e., group 0(no rhonchi), group 1(rhonchi only), group 2(mild attack), group 3(moderate attack), group 4(severe attack), group...
A Clinical Study of Bronchial Asthma in Children
Seung Hee Park, Myung Ik Lee, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1993;36(9):1291-1299.   Published online September 15, 1993
This report is a clinical analysis and comparative study with previous report of bronchial asthma at National Medical Center on bronchial asthma in children who were admitted to the MP dept. of national Medical Center from January 1987 to December 1990. The results of the study were as follows: 1) The out-break ratio of bronchial asthma is 3.7% of hopitalized children which...
Serum Eosinophil Cationic Protien(ECP) in Children with Atopic Astham
Dae Cheol Kim, Ha Baik Lee
Clin Exp Pediatr. 1993;36(6):810-819.   Published online June 15, 1993
Eosinophils play a major role in the airway inflammation in asthma. To werify an association between airway responsiveness of asthmatics and eosinophil and/or ECP, we measured serum ECP in 23 children with atopic asthma during acute attacks and stable, and in 10 normal healthy controls. Peak flows were monitored in 15 children. The data suggest that serum ECP levels were higher...
A Significance of the Sinusitis in Asthma of Chileren
Kyong Og Ko, Young Hun Chung
Clin Exp Pediatr. 1992;35(11):1537-1545.   Published online November 15, 1992
It has long been recognized that sinusitis are commonly associated with asthma. Studies have observe a high coincidence of asthma and sinusitis. Despite observations of thease findings, a direct cause and effect relationship remains to be estabilished. So this study was undertaken to evaluate the relationship of bronchial asthma and sinusitis. 96 asthmatics and 127 non-asthmatic controls in children were taken...
Infantile Asthma and Egg Allergy
Sung Hee Lim, Hye Sun Lee, Young Min Ahn
Clin Exp Pediatr. 1992;35(9):1226-1235.   Published online September 15, 1992
Egg is known to be the most common food allergen, which induces various symptoms such as atopic dermatitis, bronchial asthma, urticaria, angioedema, gastrointestinal symproms & anaphylaxis, especially during infancy. To evaluate the clinical course & significance of egg allergy in infantile asthma, we performed diagnostic study on 44 patients who were diagnosed as infantile asthma in our hospital from 1988 to...
Late Asthmatic Responses(LARs) and Consequences on Nonspecific Bronchial Reactivity(NSBR) after Exercise and Allergen Challenges in the Children with Bronchial Asthma
Kyung A Yoon, Young Y. Koh
Clin Exp Pediatr. 1992;35(7):957-970.   Published online July 15, 1992
Exercise and allergen challenges are the main tools to investigate the bronchial responsiveness in experimentally provoked asthma. It is recognized that LAR, which often follows early asthmatic response(EAR) by 3 to 10 hours after challenge, is more closely related to the basic pathogenetic mechanisms operating in bronchial asthma. Although exercise induces an EAR within the first hour similar to allergen...
Exercise Induced Delayed Bronchoconstriction in children with Asthma
Eun Jin Choi, Hyo Kung Shin, Un Ki Yoon, Ji Sub Oh
Clin Exp Pediatr. 1992;35(6):769-775.   Published online June 15, 1992
This study was performed to investigate delayed bronchoconstriction in 17 extrinsic asthmatic children with exercise induced asthma. Pulmonary function was monitored by PEFR and FEV1 prior to exercise and serially for ten hours after about 8 minutes up and down stairs exercise. Delayed bronchoconstriction was noted in four of seventeen patients (23.5%) at 5∼9hours after exercise and % fall in PEFR...
Case Report
A Case of Chronic Recurrent Obstructive Bronchitis Associated with Gastro-Esophageal Reflux
Myung Hee Min, Sang Soo Roh, Sang Il Lee, Sang Woo Kim
Clin Exp Pediatr. 1992;35(4):556-562.   Published online April 15, 1992
It has been well established that the gastroesophageal reflux and chronic respiratory problem were closely related. Several reports in pediatric literature have implicated the aspiration of gasrtric contents as a trigger factor of cough, wheezing, and recurrent pulmonary disease. Several possible mechanisms have been proposed whereby acidic gastric content can trigger bronchospasm and, in turn, bronchospams can trigger gastroesopohageal reflux. Several tests,...
Original Article
A Clinical Study of the Effect of Early(<12 Months) Versus Late(12-24 Months) Onset in Infantile Asthma
Jae Won OH, Ji Yeon Lim, Ha Baik Lee
Clin Exp Pediatr. 1992;35(2):201-210.   Published online February 15, 1992
Asthma in infancy can be confused with a variety of airway diseases, because not all that wheezes is asthma and controversy exists as to the role of age of asthma onset in childhood asthma. This study was designed to examine the role of age and predictive capacity of elevated serum IgE for early asthma doset. We compiled data of asthmatics (n=56)...
Diagnostic Approach of The Childhood Bronchial Asthma.
Suk Hyun Ha, Ji Sun Cho, Woon Kee Yoon, Ji Sub Oh
Clin Exp Pediatr. 1990;33(12):1689-1698.   Published online December 31, 1990
Clinical and environmental studies were made on 150 cases of bronchial asthma patients who were admitted to the Wallace Memorial Baptist Hospital from January, 1987, to December, 1988. Results were as folios: 1) The age distribution showed 64.7% under 6 years old; male to female ratio was 2.4:1. 2) The peak age of onset was below 6 years of age, 80.7% of total cases being included. 3) Bronchial...
Incidence of Exercise-Induced Asthma in One Elementary School Children.
Eung Won Park, Dong Uk Kim, Won Ho Choi, Kwang Woo Kim
Clin Exp Pediatr. 1990;33(11):1557-1561.   Published online November 30, 1990
This study was conducted to find out the incidence of exercise-induced asthma in pediatric population at Pohang in Korea. We selected an elementary school near pohang. The total number of the elementary school children except who was ill at that time, was 631. They all took pulmonary function test with Wright’s Peak Flow Meter before and after exercise. The study was done from 21st...
Clinical and Epidemiologic Studies on Childhood Asthma.
Youn Mo Ahn, Sun Ho Lee, Ha Baik Lee, Hahng Lee
Clin Exp Pediatr. 1990;33(5):632-641.   Published online May 31, 1990
The one-hundred-twenty-seven asthmatic children who were diagnosed and treated either through admission or through clinic visits at the Department of Pediatrics, Hanyang University Hospital from July 1987 to March 1989, were investigated for clinical patterns and epidemiologic correlations. The diagnosis of asthma was made by typical clinical history, physical findings and laboratory examina- tion. The results were as follows: 1) Sixty-three percent of the total population at...
Post-Exercise Pulmonary Function Changes in Asthmatic Children.
Kyung Ae Yoon, Young Yull Koh, Hyung Ro Moon
Clin Exp Pediatr. 1989;32(8):1074-1085.   Published online August 31, 1989
To determine the frequency, severity, time course and relations of exercise induced changes in lung function, forty-one asthmatic children and fifteen control children were subjected to free running and forced vital capacity (FVC), one-second forced expiratory volume (FEV1), maximum mid-expiratory flow rate (FEF 25-75%), and peak expiratory flow rate (PEFR) were measured before and serially for 60 minutes following exercise. The results were as follows. 1) Significant...
The Effect of Infantile Eczema on the Development of Allergic Diseases.
Hee Sup Kim, Chang Sung Lee, Sung Hwan Kim, Sang Il Lee, Sung Jae Suh, Pyung Nam Kim
Clin Exp Pediatr. 1989;32(6):834-838.   Published online June 30, 1989
For the evaluation of the correlation between infantile eczema and other allergic disorders in childhood, we performed the study which included questionnaire and allergic skin test, in July through August, 1987. Eight hundred and thirty three students were selected randomly from the middle class in Seoul. All the materials were grouped into four; early primary school group (6-8 years of age; EPSG), late primary...
The Use of Continuous Theophylline Infusion in Pediatrc Severe Bronchial Asthma.
Jae Wook Lee, Hyang Suk Hyun, Byung Hak Lim, Im Ju Kang
Clin Exp Pediatr. 1989;32(5):678-686.   Published online May 31, 1989
When a pediatric patient is seen in severe bronchial asthma, he or she is treated with an intravenous theophylline preparation that is administered in an initial intravenous loading followed by a constant infusion. But when constant infusion is impossible, a fourth of the 24 hours calculated dosage may be preferred intravenously every 6 hours. We compared the time interval to steady state, pulmonary function at...
Psychosocial Screening of Childhood Asthmatic Parient by PSC(Pediatric Symptom Checklist).
Hye Hyun Kim, Keun Lee
Clin Exp Pediatr. 1989;32(5):670-677.   Published online May 31, 1989
It has been accepted that psychosocial difficuties are frequently associated with asthma of childhood, as etiologic factor and/or consequence of the disease. Management of these psychosocial problems has great impact on the course of asthma and early finding of the problems has been strongly advocated. The purpose of this study was to evaluate psychosocial functioning of asthmatic patients and compare them with other groups...
An Epidemiological Study of Bronchial Asthma in Children Who Visited the Emergency Room.
Ju Kwan park, En Jung Kim, Bok Yang Pyun, Sang Jhoo Lee
Clin Exp Pediatr. 1989;32(2):215-222.   Published online February 28, 1989
Presently, an increasing incidence of Bronchial asthma in children is of concern to medical professionals. Worldwide data from surveys indicate a wide range for the prevalence of childhood asthma, it has been estimated that 5-10% of the young population. An epidemiological approach was used to test the prevalence of bronchial asthma out of all pediatric cases referred to the emergency room. 248 cases were selected...
Clinical and Environmental Studies on Childhood Bronchial Asthma.
Myung Suk Kim, Myung Ho Kwon, Mea Young Chung, Dong Hyuck Kum
Clin Exp Pediatr. 1988;31(12):1612-1618.   Published online December 31, 1988
Clinical and environmental studies were made on 60 cases of bronchial asthma patients who were admitted to the Koryo General Hospital from July 1985 to June 1986. Results were as follows: 1) The peak age of onset was below 6 years of age, 76.7% of total cases being included. 2) Bronchial asthma occurred most common in fall (38.3%), especially in September (15%). 3) Eosinophilia was noted in 58.3%...
Non-specific Immunotherapy with Histamine-Gammalobulin Preparations in Chronic Respiratory Group Patients and Non-atopic Asthmatic Children.
Byeung Ju Jeoung, Kyu Earn Kim, Ki Young Lee
Clin Exp Pediatr. 1988;31(10):1308-1314.   Published online October 31, 1988
We evaluated the therapeutic effect of non-specific immunotherapy with Histamine- gammahlobulin in 60 patients. Among them 22 patients were chronic respiratory group patients who were under 2 years of age and suffered from frequent respiratory tract infections, and 38 patients were as follows: 1) Excluding the patients who received 9 weeks therapy for the test period, the mean duration of Histamine-gammaglobulin therapy in the chronic respiratory...
Clinical and Epidemiological Studies on Childhood Bronchial Asthma.
Dong Hak shin
Clin Exp Pediatr. 1987;30(12):1368-1377.   Published online December 31, 1987
Chilhood bronchial asthma tends to be increased annually and overall incidence is about 3-10% of childhood age. Asthma is a troublesome disease during school life and nocturnal attacks often frighten the family. Asthma is a chronic obstructive pulmonary disease but usually self remmission with or without specific treatment. Asthma can be triggered by a variety of causative facotrs such as extrinsic, emotional, environmental,...
A Survey of the Outcome of Childhood Asthma.
Hyung Ja Park, Myung Ik Lee, Sun Wha Kim, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1987;30(1):55-63.   Published online January 31, 1987
An outcome of 416 children who was diagnosed and treated for bronchial asthma at pediatric department of National Medical Center from 1965 to 1984 was surveyed using return postcard. The following results were obtained. 1) We mailed 416 cards and 74 cards (17.8%) were returned. 2) 37.8% of the patients had been entirely asymptomatic for a year or more and 32.5% improved. 22.9% of the patients...
The Clinical Observations in Childhood Asthma.
Bae Young Kim, Hyun Soo Park, Hae Sun Yoon
Clin Exp Pediatr. 1986;29(8):880-887.   Published online August 31, 1986
The clinical observations and the significances of IgE level on 38 cases with bronchial asthma who were admitted to the Dept, of Ped. Dong San Sacred Heart Hospital Hallym University from Oct. 1984 to Sept. 1985. The result were followings: 1) The peak age incidence of bronchial asthma was 3 to 10 year of age. The ratio of male to female...
Post-exercise Pulmonary Function Changes in Asthmatic Children.
Hee Joo Jeon, Jong Woo Shin
Clin Exp Pediatr. 1986;29(4):353-360.   Published online April 30, 1986
The pulmonary function tests were made after exercise provaction using bicycle in 22 :asthmatic and 6 healthy children. The results obtained were summarized as follows: 1) There was no significant difference in pre-exercise pulmonary function tests between asthmatic and control children. 2) Among 22 asthmatic children, 17-10 children(77.3%~45.5%) according to different test indices, showed significant air way obstruction after exercise. 3) In the time...
Change of Pulmonary Function after Exercise Loading Test and Preventive Measures on Exercise-induced Asthma in Chlidren.
Ki Yung Lee
Clin Exp Pediatr. 1986;29(3):277-286.   Published online March 31, 1986
143 cases(106 males, 37 females) with asthmatic children (aged from 54/i2 to 144/i2 year old) were performed pulmonary function test before and after exercise to detect exerciseinduced asthma (El A). If peak expiratory flow rate(PEFR), checked with Wright’s peak flowmeter, decreased 15% cr more after exercise loading test (up and down stair method for 6 minutes), the result was considered to...
A Study on Methacholine Challenge Test in Asthmatic Children.
Yong Gab Kwon, Ki Young Lee
Clin Exp Pediatr. 1985;28(11):1073-1081.   Published online November 30, 1985
A diagnosis of asthma is most confidently made by actually exposing the patient to the suspected allergen (by either inhalation or ingestion) and evoking the allergic response. Several methods are known for these kinds of provocation test for the diagnosis and differential diagnosis of asthma and one of the widely-used such test is methacholine challenge test which utilized the fact...
Clinical Studies on Childhood Bronchial Asthma.
Kwang Nam Kim, Soo Yup Lee, Ha Baik Lee, Kyu Hwan Lee, Woo Gill Lee, Keun Soo Lee
Clin Exp Pediatr. 1985;28(10):997-1006.   Published online October 31, 1985
The results of clinical observation and hematologic findings on 120 cases with bronchial asthma who were admitted to the department of pediatrics, Hanyang University Hospital from Mar. 1984 to Feb. 1985 were as followings: 1)As to the age distribution, 80% of total cases were under 7-year-old and the sex ratio was 2.6 . 1 with male predominance. 2)As to the...
A Clinical Observation on Childhood Bronchial Asthma.
Hi Ju Park
Clin Exp Pediatr. 1985;28(10):989-996.   Published online October 31, 1985
The clinical observation on 50 bronchial asthma patients were seen at the Department of Pediatrics, P.N.U. H. from July 1983 to July 1984. The results were following: 1)Age distribution at the time of visiting Allergic Clinic ranged between 1 year and 15 years. Most patients(56%) were between and 9 years of age. Sex ratio was 2.3 : 1 with, male...
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