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Original Article
HLA Typing, Islet Cell Antibody and C-Peptide of Insulin Dependent Diabetes Mellitus in Children.
Hyeong Rae Cho, Sei Joong Ko, Duk Hi Kim, Hyun Chul Lee, Kap Bum Huh
Clin Exp Pediatr. 1990;33(12):1705-1712.   Published online December 31, 1990
35 childhood insulin-dependent (Typel) diabetes mellitus were typed for HLA and examined for presence of islet cell antibody and level of C-peptide. The following results were obtained: 1) HLA types were present as follows; HLA A24 (9) in 58%, DR3 in 38% and DR4 in 62%. This was slightly higher than the Korean population of 38%, 7% and 48% but there was no significant difference. 2) When...
Diagnostic Significance in Case with Growth Hormone Deficient Dwarfs.
Duk Hi Kim, Mi Jung Park, Yan Kyu Lee
Clin Exp Pediatr. 1990;33(12):1699-1704.   Published online December 31, 1990
As the scope for treatment with GH widens, it is of interest to evaluate those criteria that are used conventionally for diagnosis of GH deficiency. 11 patients with hypotha lamic-pituitay lesions and 11 patients with idiopathic GH deficiency underwent retesting GH secretion with insulin or arginine stimulation test. All 11 parients with organic GH deficiency remained GH deficient. Of the 11 retested patients with...
Study on Pubertal Changes in Adolescent Girls.
Sang Mi Ha, Ki Soo Pai, Un Jun Hyoung, Duk Hi Kim
Clin Exp Pediatr. 1990;33(7):989-998.   Published online July 31, 1990
Puberty is the period of transition from childhood to adulthood whereby rapid growth takes place psychologically and physically, especially sexual maturation. Puberty usually starts at 10 to 12 years and ends at 17 to 19 years. However due to recent improvement in general hygiene, nutrition and standard of living, puberty comes at an earlier age. Three thousand nine hundred and ninety seven girls from...
Transsphenoidal Meningoencephalocele in Association with Hypopituitarism ans Congenital Dysplastic Optic Disc: A Case Report.
Chang Gee Kang, Jung Wan You, Sung Chul Shin, Myung Goo Min, Duk Hi Kim, Jin Guk Kim, Oh Wong Kwon, Tae Sub Chung
Clin Exp Pediatr. 1990;33(6):842-847.   Published online June 30, 1990
Transsphenoidal meningoencephalocele is congenital defects in the sphenoid bone through which meninges and brain tissue have herniated; the defect, located in the midline of the base of the skull, was first reported by Richter in 1813. The nine cases of transsphenoidal meningoencephalocele have been reported. Patients with transsphenoidal meningoencephalocele also may have other midline craniocerebral and midfacial anomalies, including additional meningoencephalocele hypertelorism, cleft palate, and abnormalities...
A Case of Sexual Precocity with Congenital Hypothyroidism.
Wan Kyu Lee, Eun Jun Hyung, Duk Hi Kim
Clin Exp Pediatr. 1990;33(2):259-263.   Published online February 28, 1990
Sexual precocity in assocition with congenital hypothyroidism is a rare clinical entity. We experi- enced a case of sexual precocity, such as vaginal bleeding, breast development in a patient with congenital hypothyroidism' We present with the brief review of related literature.
Effects of long-term anticonvulsant therapy of thyroid function.
Sei Joong Ko, Duk Hi Kim, Chang Jun Coe
Clin Exp Pediatr. 1989;32(11):1533-1539.   Published online November 30, 1989
Serum concentrations of total triiodothyronine (T3) and thyroxine (T4) as well as serum thyroid- stimulating hormone (TSH) were measured in 108 patients with childhood epilepsy taking anticonvul- sants and in 54 normal healthy children as control group. Of these 108 patients, 23 were treated with carbamazepine alone, 17 were phenytoin alone and the rest 68 were treated with combination of two or more drugs...
Study on Antithyroid Antibody and Thyroid Functional Status in Patients with Turner Syndrome.
Bo Young Lee, Duk Hi Kim, Kir Young Kim
Clin Exp Pediatr. 1989;32(10):1397-1401.   Published online October 31, 1989
This study is a systematic cytogenetic and clinico-hormonal analysis of 26 cases who were diagnosed as Turner syndrome at the Yonsei Medical Center from Jan. 1978 to Jan. 1988. Antithyroid antibody and thyroid function tests were performed in Turner syndrome(3 groups according to karyotypes) and control group. The results were as follows: 1) The incidence of positive antithyroid antibody in the 26 cases was 42.3% and...
Effect of Oxandrolone Therapy in Short Stature.
Yil Sub Lee, Soo Young Lee, Duk Hi Kim
Clin Exp Pediatr. 1989;32(9):1273-1281.   Published online September 30, 1989
Fifty six boys and 28 girls aged 4 to 15.8 years were treated with oxandrolone during the 4 to 25 months. Measurement of height and bone age were made at the beginning and at 6 months intervals. The daily dose were 0.08 mg to 0.28 mg per kilogram. Predictions for adult height at the beginning of the study were compared with those at...
Clinical Study of Hypophosphatemic Rickets.
Seok Min Choi, Duk Hi Kim, Chin Suck Suh
Clin Exp Pediatr. 1989;32(8):1057-1063.   Published online August 31, 1989
Hypophosphatemic rickets is a disorder characterized by a normal or slightly reduced serum calcium level, a moderately reduced serum phosphorus level and elevated alkaline phosphatase activity. The usual mode of inheritance is X-linked dominant and postulated mechanism is a selective disorder of tubular reabsorption of phosphate, defective conversion of 21-hydroxyvitamin D3 to calcitriol and increased catabolism of calcitriol. In children with renal hypophosphatemic rickets, growth...
Goiter in Children.
Young Wan Kim, Duk Hi Kim, Byeung Ju Jeoung
Clin Exp Pediatr. 1988;31(8):1028-1036.   Published online August 31, 1988
We studied 197 cases of patients with goiter who visited Department of Pediatrics, Yonsei University College of Medicine from January 1980 to June 1987. For each patient, serum T4, free T4, T3, TSH, antithyroid antibody, and antimicrosomal antibody were analyzed, thyroid scan was performed, and radioiodine uptake was measured. Following results were obtained: 1) Male to female ratio of 197 cases of goiter was 1:7.5, predominent...
The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(7):914-923.   Published online July 31, 1988
The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man. The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment...
Neurologic Outcome in Congenital Hypothyroidism.
Byeung Ju Jeoung, Duk Hi Kim, Chang Jun Coe, Hang Cho Kang
Clin Exp Pediatr. 1988;31(7):901-913.   Published online July 31, 1988
Congenital hypothyroidism is one of the most common endocrine disease in childhood and is a major cause of mental retardation. It is clear that the earlier treatment is started, the better intellec- tual potential and the likely absence of neurological sequellae. The present study was carried out to try to define the incidence and the nature of the neurologic disorders and to examine the...
Clinical Study on Growth Hormone Deficient Dwarfs.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(5):597-606.   Published online May 31, 1988
34 patients with growth hormone (GH) deficiency were studied. The affected males outnumber females in a proportion of 1.8 to 1. The chronological ages on diagnosis was average 9.4 years old and bone age was delayed with average 6.6 years old. The major cause of GH deficiency was idiopathic and organic causes such as craniopharyngioma, germinoma & Tb. meningitis were relatively uncommon. Cerebral anoxia seemed...
The Effect of Thyroid Hormone Deficiensy on Growth Hormone Levels.
Duk Hi Kim, Chan Il Park
Clin Exp Pediatr. 1988;31(1):64-71.   Published online January 31, 1988
Growth hormone and thyroid hormone are known to affect growth and development. The present experiment was undertaken to assess GH levels in the serum and pituitary gland of prophylthiouracil (PTU) treated rats. The serum concentration of T4 were decreased during PTU treatment. Serum GH concentration and pituitary GH content were decresed with severity of hypothyroid status. After withdrawl of PTU, their levels were recovered gradually. Acidophil...
A Clinical Studies in Patients with Turner's Syndrome.
Chang Hyun Yang, Duk Hi Kim, Kir Young KIm, Young Ho Yang
Clin Exp Pediatr. 1987;30(10):1143-1151.   Published online October 31, 1987
This study is systematical cytogenetic and clinico-hormonal analysis of 42 cases who were diagnosed as Turner’s syndrome at the Yonsei Medical Center from Jan. 1971 to Dec. 1985. The careful history taking, physical examination, cytogenetic studies, radiologic and hormonal evalua- tion, and GnRH stimulation test were performed. The results were as follows. 1) The patients ranged in age from 14 months to 30 years at the...
Clinical Study of Diabetes Insipidus.
Jung Bae Lee, Duk Hi Kim
Clin Exp Pediatr. 1987;30(8):882-890.   Published online August 31, 1987
From Aug. 1979 to June 1986 we reviewed 27 patients with diabetes insipidus to observe the clinical features, laboratory findings and treatment of diabetes insipidus. The results were as follows: 1) Central diabetes insipidus were 22 cases (81.5%) and nephrogenic diabetes insipidus were 5 cases (18.5%). Etiologic factors in the central diabetes insipidus included idiopathic (54.6%), craniopharyn- gioma (18.2%), germinoma (13.6%), post-encephalitis (9.1%) and Histiocytosis X...
Case Report
A Case of Renal Candidiasis Associated with Type I Diabetes Mellitus.
Shin Heh Kang, Jae Seung Lee, Duk Hi Kim
Clin Exp Pediatr. 1987;30(6):677-683.   Published online June 30, 1987
We have experienced a case of renal candidiasis in type I DM (IDDM). The patient was a 15-year old girl who suffered from type I DM since 3 years earlier with development of retinopathy, cataract & renal failure. Ultrasonic examination revealed multiple fungus balls in renal pelvis & urinary bladder. Candida tropicalis was cultured from fungus balls passed during urination. A brief...
Original Article
A Study on Serum Growth Hormone in DM of Childhood.
Duk Hi Kim
Clin Exp Pediatr. 1987;30(2):175-180.   Published online February 28, 1987
The human growth hormone (hGH) levels were evaluated in 13 diabetes mellitus, 11 patients were insulin dependent diabetes (ages 2 yr 10 mo to 13 yr 14 mo), 2 patients were noninsulin dependent diabetes (age 12 yr & 12 yr 5 mo). No difference in hGH level was observed in relation to duration of diabetes. The hGH responses to glucagon 1 mg injection in...
Juvenile Chronic Lymphocytic Thyroiditis.
Duk Hi Kim
Clin Exp Pediatr. 1987;30(1):71-79.   Published online January 31, 1987
A diagnosis of chronic lymphocytic thyroiditis(CLT) was made in 90 children & adolescents according to Fisher’s criteria. The age of the group ranged between 4 years & 16 years. On the basis of serum T4, T3 & TSH, three groups of patients were distinguished at the time of diagnosis.: euthyroid group (n=49), hyperthyroid group (n=7), hypothyroid group (n=34), where three subgroups were classified;...
Case Report
A Case of Hutchinson-Gilford Progeria Syndrome.
Byeung Ju Jeoung, Duk Hi Kim
Clin Exp Pediatr. 1986;29(10):1138-1142.   Published online October 31, 1986
Recently, the authers experienced a case of Hutchinson-Gilford Progeria sydrome which is characterized by stunded growth, premature aging and normal intelligence. They die prematurely as a results of myocardial infarction with on average age of 13. Berief review of the literatures was made.
Original Article
A Study on Hormonal Change of Lh, FSH, and Testosterone and Testicular Volumes in Pubertal Mal Children.
Heung Dong Kim, Duk Hi Kim, Ki Keun Oh
Clin Exp Pediatr. 1986;29(9):979-987.   Published online September 30, 1986
The mechanism involved in pubertal changes has not been clearly demonstrated, but evidence has been accumulated that hormonal changes are responsible for this pubertal changes. We studied the height, weight, testicular volume, bone age, LH, FSH, and testosterone, "by Tanner stage of pubic hair development in 134 pubertal male children with no previous endocrine disease, who admitted at Yonsei University Medical...
Clinical Studies on Sexual Precocity.
Ki Seok Ahn, Duk Hi Kim
Clin Exp Pediatr. 1986;29(3):255-264.   Published online March 31, 1986
The majority of cases of sexual precocity is idiopathic, but it can be caused by the intracranial lesions, gonadal or adrenal disorders. Clinical studies on the 33 cases of precocious puberty who visited the Dept, of Pediatrics of Yonsei Medical Center from Aug. 1978:to July 1984 were subjected in this study. The careful history taking, physical examination, radiologic and hormonal...
The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus.
Duk Hi Kim
Clin Exp Pediatr. 1985;28(6):564-569.   Published online June 30, 1985
A 2 year 10 month old girl with 6 weeks duration and 13 year 4 month old boy with 8 weeks duration were given cyclosporin for 68 days. Therapy was initiated orally at the dosage of 10 mg per kg of body per day. Blood glucose, C-peptide, cyclosporin, creatinin, BUN and transaminase were checked regularly. Cyclosporin treatment allowed two patients to...
The Study on Residual Beta-cell Function in Children with Dibetes Mellitus.
Duk Hi Kim
Clin Exp Pediatr. 1985;28(5):492-498.   Published online May 31, 1985
C-peptide can be used as a measure of endogenous insulin secretion in insulin treated diabetes mellitus. Pancreatic p cell secretory activity was measured in 11 patients with insulin dependent and 2 patients with non insulin-dependent diabetes mellitus by means of serum C-peptide response to 1 mg of glucagon subcutaneously. Serum C-peptide was increased to near normal range in the remission phase and...
Case Report
A Case of Thyroid Papillary Adenocarcinoma.
Duk Hi Kim, Chul Lee, Pyung Kil Kim, Byung Soo Kim, Yi Ho Hwang, Kyung Sik Lee, Woo Hee Chung
Clin Exp Pediatr. 1984;27(3):288-292.   Published online March 31, 1984
We report a case of thyroid papillary adenocarcinoma in a 5 year 1 month old boy. His major problem was palpable thyroid nodule & cervical lymph nodes. Extensive bilateral pulmonary metastasis was noticed. The metastatic thyroid carcinoma was regressed after therapeutic doses of radioiodine without total thyroidectomy.
Cushing'S Syndrome In Childhood.
Duk Hi Kim, Nan Ae Kim, Do Kwang Yun, Duk Jin Yun, Eui Ho Hwang
Clin Exp Pediatr. 1983;26(6):593-597.   Published online June 30, 1983
There are little reports on Cushing’s syndrome in children. We have seen a case of Cushing’s syndrome due to left adrenal adenoma from 5 year 6 months old girl. She has been complained from obesity with, buffalo hump, hirsutism and vaginal spotting. Her blood cortisol levels were high and no diurnal variation. No suppression was occurred following dexamethasone 1 mg overnight or 4 mg...
Original Article
True Hermaphroditism, Report of Eight Cases.
Duk Hi Kim, Chul Young Lee
Clin Exp Pediatr. 1983;26(5):435-439.   Published online May 31, 1983
True hermaphroditism is the most uncommon variant of intersexuality in the human beings A case of truehermaphroditism contains both ovarian and testicular tissue. Author’s eight cases of true hermaphroditism are described with 373 cases reviewed in the literature. Three cases show lateral ovary and testis, one bilateral ovotestes, one ovotestis-testis, one ovotestis, ovary and two undetermined. 46 XX chromosomal complement is the most...
Case Report
A Study of Intersex.
Chul Young Lee, Duk Hi Kim, Moo Sang Lee, Seung Kang Choi
Clin Exp Pediatr. 1982;25(6):607-615.   Published online June 30, 1982
Intersex is the state of having ambiguous or inappropriate genitalia due to abnormalities of normal mechanisms for sexual development. Three broad subcategories of intersex have been defined according to the histology of the gonad: Female & male pseudohermaphroditism and true hermaphroditism. Twenty two cases of intersex are described. Among them, true hermaphroditism was 7 cas-es, female pseudohermaphroditism 10 cases and...
Original Article
Hashimoto's Thyroiditis in childhood.
Hee Jung Chung, Back Keun Lim, Duk Hi Kim, Duk Jin Yun, Chan Il Park
Clin Exp Pediatr. 1981;24(8):752-759.   Published online August 15, 1981
Serum levels of T3, T4, TSH, 24-h RAIU and Thyroid antibodies were examined in 13 cases of chronic lymphocytic thyroiditis who were diagnosed at the pediatric department of Yonsei University hospital during the period from 1978 to 1980. The results were as follows: 1. The age distribution was dispersed between 8 and 15 years of age and all the cases...
A Clinical and Pathological Study on the Treatment and Course of Purpura Nephritis in Chidren.
Jae Seung Lee, Sang Hak Park, Duk Hi Kim, Pyung Kil Kim, Duk Jin Yun, In Joon Choi
Clin Exp Pediatr. 1981;24(5):466-476.   Published online May 15, 1981
Purpura nephritis, one of the commonly known complications of allergic purpura has variable symptoms ranging from mild transient hematuria to severe nephrotic syndrome leading to renal failure and death. This paper reports on the treatment and course of purpura nephritis with special reference to serum immunoglobulins and immunopathology. These cases were selected among pediatric patients with purpura nephritis admitted to...
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