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Original Article
The Perinatal Complications in Infants of Mothers with Gestational Diabetes Mellitus
Ju Yeon Yeo, Seong Won Yang, Hye Kyung Han, Mi Ryung Um, Woo Gill Lee, Mi Na Lee, Hak Chul Jang, Ho Yeon Jung, Eun Sung Kim, Kyu Byung Jung
Clin Exp Pediatr. 1997;40(6):809-917.   Published online June 15, 1997
Purpose : This study was performed to examine the impact of gestational diabetes mellitus (GDM) on perinatal outcomes, especially macrosomia and metabolic complications in Korean women. Methods : We studied perinatal outcomes of 65 women with GDM who delivered a singleton infant and were not complicated by medical disease that might effect the fetal growth, 65 women with normal glucose tolerance were selected to match subject...
Case Report
A Case of Disseminated Pagetoid Reticulodsis
Hyang Mi Kwon, Sun Seong Park, Hye Lim Jung, Dong Hyuck Keum, Kye Yong Song
Clin Exp Pediatr. 1995;38(7):988-992.   Published online July 15, 1995
Pagetoid reficulosis is a rare skin disorder consisting of localized(WoringerKolopp type) or disseminated (Ketron-Goodman type), asymptomatic hyperkeratotic, cutaneous plaque. The disseminated form has clinical similarities with mycosis fungoides and histologically characteri-sed by prominent infiltration of cytologically atypical mononuclear cells within a hyperplastic epidermis. It is suggested that the infiltrating cells orginate from T-lymphocytes. A 6yr old male patient visited with...
Treatment of Vaginal Endodermal Sinus Tumor
Seok Joo Han, Myo Kyung Lee, Chuhl-Joo Lyu, Byung Soo Kim, Eui Ho Hwang
Clin Exp Pediatr. 1995;38(5):707-712.   Published online May 15, 1995
An endodermal sinus tumor of the vagina, a rare pediatric malignancy, was managed with c onservative surgey followed by adjuvant chemotherapy(vincristine, actinomycin D, cyclophosphamide : VAC). Treatment related complications were acceptible, and there is no evidence of d isease twenty months after diagnosis. As a treatment option, primary conservative surgery and adjuvant chemotherapy is viewed as a highly attractive alternative...
Original Article
Results of Chemotherapy of Hepatoblastoma and Hepatocellular Carcinoma in Children
Kyung Duk Park, Gi Woong Seong, Jae Kyung Lee, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1995;38(2):195-206.   Published online February 15, 1995
Purpose : Surgical excision has been the primary treatment for hepatoblastoma and hepatocellular carcinoma. However, at presentation, only one third of such tumors are surgically resectable. Without operation, the disease is fatal. Therefore, neoadjuvant chemotherapy has been introduced for conversion of the unresectable tumors into the resectable ones. We studied th e effects of chemotherapy for hepatic malignancy in children. Methods...
Case Report
A Case of Pulmonary Blastoma
Yun Jeong Chang, Jeong Hee Kim, Sun Ki Kim, Byong Kwan Son, Joon Mi Kim, Young Chae Chu
Clin Exp Pediatr. 1994;37(7):999-1005.   Published online July 15, 1994
Pulmonary blastoma is a rare type of malignant lung tumor comprised of epithelial and mesenchymal elements reminiscent of fetal lung. Mesenchymal element may show various patterns of differentiation toward mature tissue, such as cartilage, smooth muscle, and bone. Rhabdomyoblastic differentiation in pulmonary blastoma is quite rare. Our case of pulmonary blastoma with rhabdomyoblastic differentiation documented by electron microscopy and immunohistochemistry. Usually...
Original Article
A Study on Non-Organic Failure to Thrive Infants
Keun Lee
Clin Exp Pediatr. 1994;37(4):464-471.   Published online April 15, 1994
Failure to thrive(FTT) is defined when the weight of a child is below 3rd percentile or when there is sudden weight loss in history. If organic cause of the weight loss is not found, it is called non-organic failure to thrive (NETT). Relatively little attention has been paid to NFTT in Korea for various reasons and the incidence is...
A Clinical Study on Infants of Diabetic Mothers
Gyeong Choe, Young Kwon Choi, Young Youn Choi, Tai Ju Hwang
Clin Exp Pediatr. 1993;36(10):1407-1416.   Published online October 15, 1993
Thirty one infants of diabetic mothers(IDM) who had been admitted in Neonatal Intensive Care Unit at Chonnam University Hospital from January 1987 to July 1991 were studied for evaluation of their perinatal outcome and prognosis. The results were as follws; 1) The distribution of diabetic mothers according to modified White뭩 classification was GD & class A in 12 cases (38.7%), B in...
A Clinical Study of Childhood Soft Tissue Sarcoma
Hye Lim Jung, Hong Heo Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1993;36(9):1258-1270.   Published online September 15, 1993
Medicine, Seoul, Korea Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea To study the clinical characteristics and treatment results of childhood soft tissue sarcoma, the retrospective study was performed on 67 patients with soft tissue sarcoma, experienced at the Department of Pediatrics, Seoul National University Hospital from January, 1982 to July, 1990. The...
Intermittent Central Nervous System Irradiation and Intrathecal Chemotherapy for Recurrent Central Nervous System Leukemia in Children
Joon Ho Bang, Nak Gyun Chung, Woo Gun Choi, Hack Ki Kim, Kyong Su Lee, Man Kyu Yang
Clin Exp Pediatr. 1993;36(8):1067-1072.   Published online August 15, 1993
Between 1986 and 1990, four children with recurrent CNS leukemia who had previous NS prophylaxis therapy were treated with intermittent central nervous system irradiation and intrathecal chemotherapy (IIC). There was no isolated CNS recurrence. One patient died from bone marrow relapse. Three patients are alive without evidence of disease for 33/12 year to 36/12 years after the diagnosis of recurrence...
Outcome in Infants of Mothers with Systemic Lupus Erythematosus
Chang Ryul Kim, Young Pyo Chang, Hee Seop Kim, Mi Jung Kim, Byung Il Kim, Jung-Hwan Choi, Chong Ku Yun, Bo Hyun Yoon, Hee Chul Syn, Syng Wook Kim, Seon Yang Park, Hahng Lee
Clin Exp Pediatr. 1993;36(6):791-804.   Published online June 15, 1993
A large proportion of patients with systemic lupus erythematosus(SLE) are women of reproductive age. Their fetal outcome is undoubtedly less favourable than in haelthy women. Although there is no evidence of an increase in congenital anomalies, increased frequencies of miscarriage, stillbirth, growth retardation, and preterm delivery are recognized It mainly depends on the compromise of uteroplacental circulation such as renal...
Clinical Study on Infants of Diabetic Mothers
Eun Eui Kim, Min Jeong Kim, Yang Sook Choi, Son Sang Seo
Clin Exp Pediatr. 1993;36(3):347-355.   Published online March 15, 1993
A clinical observation was performed on the 80 cases of neonates born from diabetic mothers among the total of 34,936 neonates delivered at Il Sin Christian Hospital from January 1985 to December 1989. The results were as follows : 1) The incidence of infants of diabetic mothers was 0.23%, among whom gestational diabetic mothers were 63 cases(78.7%) and overt diabetic mothers...
Case Report
An Autopsy Case of Infant of Diabetic Mother with d-Transposition of Great Arteries and Hypertrophic Cardiomyopathy
Kye Hwan Seol, Eui Kyeung Jung, Chang Sung Son, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1992;35(4):545-550.   Published online April 15, 1992
Generally, infants of diabetic mother(IDM) have various diseases and complications affecting multisystems resulting in high perinatal morbidity and mortality. It is well known that IDM have especially higher incidence of congenital anomalies including congenital heart disease(CH D). dTransposition of great arteries(d-TGA), ventricular septal defect and hypertrophic cardiomyopathy(HCM) form most of CHD occurring in IDM. Of these, HCM appears as a...
Three Cases of Brain Tumors with Bone Metastasis
Eun Joo Kim, Kyung Duk Park, Eun Sil Dong, Hye Jung Park, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn, Je Geun Chi
Clin Exp Pediatr. 1992;35(3):381-389.   Published online March 15, 1992
Medulloblastoma and primitive neuroectodermal tumor(PNET) are relatively common intracranial neoplasms in childhood. Their extracranial metastasis were thought to be rare occurrences. But they are more frequent compared to other intracranial tumors. The most frequent site of metastasis deposits in medulloblastoma is bone, and metastasis to lymph node, peritoneum, liver or lung have been reported infrequently. The authors experienced three cases...
Erratum
Pediatric Cancer Patients' Understanding of Their Disease and the Attitudes of Their Parents Towards the Care of the Child with Cancer
Eun Kyung Bom, Tai Ju Hwang, Hoon Kook
Accepted January 1, 1970  
Providing pediatric cancer patients with medical information is thought to facilitate realistic coping; however, systematic research into this concept has been lacking. We analyzed the attitudes of nationwide 220 cancer patients, their parents and doctors towards the care of children with cancer, concerning the patients' understanding of their diseases, from whom the patient heard about his(her) disease, whether the patient...
Original Article
Clinical Considerations of the Mediastinal Tumors in Children
Eun Joo Kim, Hye Lim Jung, Hong Hoe Koo, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1992;35(1):98-107.   Published online January 15, 1992
Mediastinal tumors of children constitute a heterogeneous group of malignant and benign neoplasms because they originated from a variety of structures. But they show some characteristics in type of tumor according to location, relative frequency of masses, clinical manifestations. Management and long-term reusult. We observed 82 patients less than 16 years of age who were evaluated and treated for a...
Clinical charateristics of pregnancy-induced hypertensive mothers and their neonates.
Soo Jeong Ryu, Jin Sook Kim, Kyong Hoon Choi, Myong Jin Kim, Mi Na Lee
Clin Exp Pediatr. 1991;34(7):929-933.   Published online July 31, 1991
The results were as follows; 1) The mean platelet count of peripheral blood in pergnancy-induced hypertensive mothers was 221, 733±17,357/mm3 which was than control Significant thrombocytopenia was encountered in 8 cases 2) Meanwhile their newborns showed neutropenia and prolongation of prothrombin time. 3) Intrauterine growth retardation could be assesed in 8 out of 30 newborns from these mothers.
Two cases of nasopharyngeal carcinoma in children.
Tae Sun Ha, Chul Ho Jang, Hee Young Shin, Hyo Seop Ahn
Clin Exp Pediatr. 1991;34(4):587-593.   Published online April 30, 1991
Nasopharyngeal carcinoma is a primary malignancy of nasopharyngeal epithelium, firstly de- scribed as a separate entity by Regaud and Schmincke in 1921. Although it is a rare tumor, reprsent- ing less than 1% of pediatric malignancies, it accounts for 9% of the nasopharyngeal neoplasms of childhood, and has not been reported in Korean child. We experienced two cases of nasopharyngeal carcinoma in a 10...
Clinical Evaluation on Newborn of Teenage Pregnancy.
Man Cheol Ha, Chan Yung Kim
Clin Exp Pediatr. 1990;33(3):306-314.   Published online March 31, 1990
The authors have analysed the clinical characteristics of 117 cases of teenage pregnancy and their 122 newborn cases who were visited Pusan National University Hospital and Hae Sung Hospital from January 1982 to August 1988. The results were summarized as follows; 1) The youngest teenage mother was 14 years old, and below 17 years old was 28.2% and the remainder were between 18 and 19 years...
A clinical study on histiocytosis X.
Sang Oh Na, Joong Gon Kim, Hyo Seop Ahn
Clin Exp Pediatr. 1989;32(11):1510-1519.   Published online November 30, 1989
We made a clinical study on 31 cases of histiocytosis X who had been admitted to the Dept, of Ped. of S.N.U.C.H. from Jan. 1981 to Dec. 1987. Among 31 cases, 28 patients received chemotherapy to include prednisolone, vinblastine, methotrex- ate and cyclophosphamide as induction therapy, and 6-mercaptopurine, methotrexate and cyclophos- phamide as maintenance therapy. The results obtained were as follows. 1) The sex incidence revealed male...
Hypertrophic Cardiomyopathy in Infant of Diabetic Mother.
Jeong Sam Jeon, Soo Chun Kim, Chong Woo Bae, Sung Ho Cha, Chang Il Ahn
Clin Exp Pediatr. 1989;32(8):1138-1143.   Published online August 31, 1989
Generally, infant of diabetic mother (IDM) have complex multisystems disease resulting in a high incidence of perinatal morbidity and mortality. Hypertrophic cardiomyopathy (HCM)-IDM appears as the early onset, transient and non-familial cariomyopathy in neonatal period. The etiology of the left ventricular outflow obstruction in these neonates is not clear. But, it is possible that the asymmetrical septal hypertrophy was a manifestation of the generalized...
Treatment of Acute Myelogenous Leukemia in Children: Remission Induction with Adriamycin and Cytosine Arabinoside, and Postremission Maintenance Chemotherapy with Adriamycin, Cytosine Arabinoside and 6-thioguanine.
Soon Ki Kim, Hyo Seop Ahn, Chang Yee Hong
Clin Exp Pediatr. 1988;31(7):850-862.   Published online July 31, 1988
The authers assessed the effectiveness of chemotherapy in 40 children with AML, experienced at Seoul National University Children’s Hospital during 8 years 5 months from April 1979 to August 1987. Remission induction treatment included adriamycin 30 mg/m2/day IV on days 1-3 and cytosine arabinoside 75 mg/m2/day continuous IV infusion on days 1-5. This regimen was repeated, if necessary, for one or two more courses. After...
Clinical Characteristics and Pathogenesis of Typhlitis in Childhood Non-Lymphocytic Leukemia-Considerations on Clinical Mangement with Report of Two Cases and Literature Review.
Do Hyun Kim, Sung Oh Kim, Soo Yup Lee, In Joon Seol, Hahng Lee, Chong Moo Park, Poong Man Jung, Seok Chol Jeon, Young Hyeh Ko, Jung Dal Lee
Clin Exp Pediatr. 1988;31(5):607-620.   Published online May 31, 1988
The treatment of acute leukemia in childhood has been increasingly successful due to progression of chemotherapeutics and other supportive care. Improved survival rates in acute childhood leukemia have been associated with an increasing number of complications in the gastrointestinal tract. Typhlitis also known as ileocecal syndrome is a necrotizing inflammation of the cecum in leukemic patients on chemotherapy in the terminal stage of the...
A Clinical Study of Histiocytosis in Childhood.
Hee Jung Chung, Byung Soo Kim, Chan Il Park
Clin Exp Pediatr. 1984;27(3):253-264.   Published online March 31, 1984
A clinical study with particular emphasis on the result of chemotherapy has been made on. 34 cases of histiocytosis diagnosed at the Department of the Severance Hospital and Yonsei Cancer Center from January 1975 to December 1981. The results may be summarized as follows: 1) Among histiocytosis, HSC and LSD were each present in elevent cases, E-G in seven and HMR...
A Clinical Study of Tic Disorder in Korea.
Kang E Hong
Clin Exp Pediatr. 1981;24(3):198-208.   Published online March 15, 1981
30 patients diagnosed as having tic disorder at the Child Psychiatry clinic of Seoul National University Hospital were studied in terms of sex, age, onset, precipitating factors,characteristics of the patients and family dynamics. A short term follow up study wascarried out regarding the outcomes of the symptom and the changes in attitudes and beha-viors of patients and parents. The results...
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