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Author     
Jong Seon Byun  (Byun JS) 1 Article
Original Article
Excess of leptin inhibits hypothalamic KiSS-1 expression in pubertal mice
Sung Yeon Ahn, Sei Won Yang, Hee Jae Lee, Jong Seon Byun, Ji Yeon Om, Choong Ho Shin
Clin Exp Pediatr. 2012;55(9):337-343.   Published online September 14, 2012
Purpose

Leptin has been considered a link between metabolic state and reproductive activity. Defective reproductive function can occur in leptin-deficient and leptin-excessive conditions. The aim of this study was to examine the effects of centrally injected leptin on the hypothalamic KiSS-1 system in relation to gonadotropin-releasing hormone (GnRH) action in the initial stage of puberty.

Methods

Leptin (1 µg) was injected directly into...

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