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Author     
Janardhan P. Bhattarai  (Bhattarai JP) 1 Article
Original Article
Effects of human growth hormone on gonadotropin-releasing hormone neurons in mice
Janardhan P. Bhattarai, Shin Hye Kim, Seong Kyu Han, Mi Jung Park
Clin Exp Pediatr. 2010;53(9):845-851.   Published online September 13, 2010
Purpose

Recombinant human growth hormone (rhGH) has been widely used to treat short stature. However, there are some concerns that growth hormone treatment may induce skeletal maturation and early onset of puberty. In this study, we investigated whether rhGH can directly affect the neuronal activities of of gonadotropin-releasing hormone (GnRH).

Methods

We performed brain slice gramicidin-perforated current clamp recording to examine the direct...

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