| Immunomodulation Therapy in Children with Aplastic Anemia. |
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Won Suk Suh1, Ki Sik Min1, Woo Gun Choi1, Hack Ki Kim1, Kyoung Sn Lee1, Soon Yong Lee2 |
1Department of Pediatrics, Catholic University Medical College, Seoul, Korea.
2Department of Pediatrics, Inje Medical College, Pusan, Korea. |
| 재생불량성 빈혈 환아에서의 면역조절 요법 |
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서원석1, 민기식1, 최우건1, 김학기1, 이경수1, 이순용2 |
1가톨릭의과대학 소아과학교실
2인제대학교 의과대학 소아과학교실 |
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Received: 7 July 1989 • Accepted: 26 September 1989 |
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| Abstract |
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Thirty patients with aplastic anemia(fifteen severe aplastic anemia and fifteen moderate aplastic
anemia) treated with antilymphocyte globulin and cyclosporin A as a kind of immunomodulation
therapy were studied by analysing hematologic reseponses and complications.
The results were as follows;
1) Nineteen out of thirty patients (63.3%) treated with anti lymphocyte globulin plus cyclosporin A
showed responses (complete response of 33.3%, partial response of 30.0%).
2) Hematologic responses according to the severity of disease were shown in six out of fifteen
severe aplastic anemia patients(40.0%;complete response of 13.4%, partial response of 26.6%) and in
thirteen out of fifteen moderate aplastic anemia patients(86.6%complete response of 53.3%, Partial
response of 33.3%).
3) Hematologic responses according to the difference of sex were shown in nine out of seventeen
male patients(52.9%;complete response of 17.6%, partial response of 35.3%) and ten out of thirteen
female patients(77.0 % complete response of 53.8%, partial response of 23.2%).
4) Most of the responses were noticed between 2 months and 6 months(mean:3.6 months) after the
initiation of therapy;earlist at 2 months, latest at 6 months.
5) The complications of therapy were thrombocytopenia, hypertension, fever and rash etc.,
Although this study is preliminary, our data suggest that antilymphocyte globulin plus cyclosporin
A may be useful therapeutic modality for the patients with severe aplastic anemia who can not be the
candidate for bone marrow transplantation and moderate aplastic anemia. |
| Key Words:
Aplastic anemia, Immunomodulation |
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