| The mechanism of Arginine-stimulated growth hormone secretion. |
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Wan Kyu Lee, Dong Goo Lee, Duk Hi Kim |
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Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea |
| Arginine의 뇌하수체 성장호르몬
분비촉진에 관한 기전 |
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이완규, 이동구, 김덕희 |
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연세대학교 의과대학 소아과학교실 |
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Received: 4 September 1990 • Accepted: 29 October 1990 |
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| Abstract |
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Although Arginine is widely used in the evaluation of growth hormone (GH) secretion in short
stature patient, the mechanism of action is unclear, yet. To elucidate how Arginine stimulate GH
secretion, we studied the interaction of Arginine with growth homrone releasing hormone (GHRH) on
GH secretion in GH deficient short stature patient and constitutional growth delay.
The results of the studies were as follows:
1) Peak GH response to Arginine, GHRH, Arginie with GHRH group was 4.98±2.39,11.62±3.32,
25.71±10.36ng/ml respectively. The GH AUC (area under curve) of Arginine, GHRH, Arginine with
GHRH group was 459.94±247.49, 699.99±247.40,1446.49±499.94ng/ml x min. each other. The peak
GH response and AUC were significantly higher in Arginine with GHRH group than other groups.
2) Serum somatostatin level was significantly lower in Arginine with GHRH group than Arginine,
GHRH groups.
In conclusion, we suggest that Arginine stimulate GH by inhibition of endogenous somatostatin
rather than by stimulating endogenous GHRH release. |
| Key Words:
Arginine, Growth hormone, Growth hormone releasing hormone, Somatostatin |
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