| A study on the immune reaction to the milk protein antigens in the postpartum mother, newborn baby, and children. |
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Soo chul Cho, Ju Hyung Kim, Hong Ro Lee, Jong San Lee, Pyoung Han Hwang, Jung Soo Kim |
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Department of Pediatrics, Chonbuk National University Medical School, Chonju, Korea |
| 산모와 신생아 및 소아연령에서 우유
단백항원의 면역반응에 관한 연구 |
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조수철, 김주형, 이홍로, 이종산, 황평한, 김정수 |
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전북대학교 의과대학 소아과학교실 |
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Received: 11 April 1991 • Accepted: 5 July 1991 |
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| Abstract |
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There is continuing interest in the isotype response of human serum antibodies reactive with
dietary proteins. This study was performed to clarify the humoral immune responses against cow’s
milk proteins, 分-lactoglobulin and a-lactalbumin. Milk protein specific IgG, IgA, IgM, and IgG
subclasses were measured using ELISA in the blood of various groups of age.
The results were as follows:
1) Milk protein specific immunoglobulins were higher in maternal blood compare to cord blood.
2) 分-lactoglobulin was revealed more immunogenic than a-lactalbumin.
3) IgG levels specific to 分-lactoglobulin and a-lactalbumin were highest at 6—12 months and 1 〜2
years of age respectively, after then they were gradually decreased. Changes of IgA and IgM levels
were similar to that of IgG.
4) In children of 6 〜 24 months of age, IgG levels specific to 分-lactoglobulin and a-lactalbumin were
significantly higher in sera of children fed on cow milk formula before 4 months of age than fed on
minimal cow milk formula or formula fed after 4 months of age.
5) All IgG subclasses were involved with individual isotype variations.
6) In lymphocyte stimulation test, using specific and nonspecific stimulators, 3H-thymidine uptake
was higher in maternal blood compare to that of cord blood.
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| Key Words:
Cow's milk protein, beta-lactoglobulin, alpha-lactabumin, Immunoglobulins |
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