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A case of persistent pulmonary hypertension of the newborn: Treatment with inhaled iloprost

Korean Journal of Pediatrics 2009;52(10):1175-1180.
Published online October 15, 2009.
A case of persistent pulmonary hypertension of the newborn: Treatment with inhaled iloprost
Yoon Young Jang, Hye Jin Park
Department of Pediatrics, School of Medicine, Catholic University of Daegu, Korea
Iloprost 흡입 투여로 치료한 신생아 폐고혈압 지속증 1예
장윤영, 박혜진
대구가톨릭병원 의과대학 소아과학교실
Correspondence: 
Hye Jin Park, Email: grapfarm@hanmail.net
Abstract
We report a case of a full-term neonate with persistent pulmonary hypertension who developed asphyxia after birth and was treated with iloprost. The neonate had persistent hypoxia and did not respond to supportive treatment. Because inhaled nitric oxide (iNO) was not available in our hospital, inhaled iloprost was administered via an endotracheal tube. This resulted in an immediate elevation of oxygen saturation. Echocardiography revealed the conversion of the right- to-left ductal shunt to the left-to-right one and a decrease of the right ventricular pressure. The use of inhaled iloprost did not cause any significant side effects. Here, we describe our experience where iloprost was used in a neonate with persistent pulmonary hypertension because the standard therapy with inhaled nitric oxide was not available.
Key Words: Persistent fetal circulation syndrome, Iloprost


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