| A Case of Recurrent Herpes Simplex Virus Disease of a Preterm
Infant, Who Needed Continuous Oral Acyclovir Suppressive Therapy |
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Sung Seok Kim1, Ki Woong Hong1, Eun Ryoung Kim1, Young-Don Kim2, Kyoo Man Lee3 |
1Department of Pediatrics, Sung-Ae General Hospital, Seoul, Korea
2Department of Pediatrics, College of Medicine, Ulsan University Hospital, Ulsan, Korea
3Department of Laboratory Medicine, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea |
| 지속적인 경구용 Acyclovir 억제요법이 요구된 미숙아의재발성 단순포진 바이러스 감염 1례 |
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김성석1, 홍기웅1, 김은령1, 김영돈2, 이규만3 |
1성애병원 소아과
2울산대학교병원 소아과
3한림대학교 의과대학 한강성심병원 임상병리과 |
Correspondence:
Eun Ryoung Kim, Email: nicu@chollian.net
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| Abstract |
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Neonatal herpes simplex virus(HSV) infections result in significant morbidity and mortality. Although acyclovir treatment has improved survival, severe neurological sequelae can occur in the majority of survivors. HSV infections limited to the skin, eyes and mouth(SEM) can cause neurologic impairment. A direct correlation exists between the development of neurologic deficits and the frequency of cutaneous HSV recurrences. National Institutes of Allergy and Infectious Diseases(NIAID) Collaborative Antiviral Study Group conducted a phase I/II trial of continuous oral acyclovir therapy for the suppression of cutaneous recurrences. We describe a preterm infant who had two recurrences after neonatal SEM disease had been treated with intravenous acyclovir, and there were no more recurrences after continuous oral acyclovir suppressive therapy for six months. We report this case with a review of related literature. |
| Key Words:
Herpes simplex virus, Acyclovir, Preterm infant, Skin, eyes and mouth(SEM) |
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