| The Study of Serum Vascular Endothelial Growth Factor in the Acute Febrile Phase of Kawasaki Disease |
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Minshik Kim1, Kyungsook Kim2 |
1Department of Pediatrics, Anyang Metro Hospital, Anyang, Korea
2Department of Clinicopathology, Anyang Metro Hospital, Anyang, Korea |
| 급성기 가와사끼병 환아의 혈청 Vascular Endothelial Growth Factor에 대한 연구 |
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김민식1, 김경숙2 |
1안양 메트로병원 소아과
2안양 메트로병원 임상병리과 |
Correspondence:
Minshik Kim, Email: m3tqzz@edunet4u.net
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| Abstract |
Purpose
: Kawasaki Disease(KD) is a febrile disease with acute multisystemic vasculitis associated
with early development of acute myocarditis and coronary artery abnormalities. The cause
and etiologic agents are still unknown. Clinical studies suggest that KD is one of the autoimmune
disorders caused by infectious agent, but this is not proved yet. The study was performed to
investigate the levels of vascular endothelial growth factor(VEGF) in the acute stage of KD before
treatment of intravenous-gammaglobulin(IVGG) to confirm and find an early diagnostic method of
vasculitis by serologic test.
Methods
: The patient group consisted of 61 cases in acute stages of KD before treatment of
IVGG who were hospitalized from Jan. 1998 to Feb. 2001. The control group consisted of 24 cases
among the admitted cases who suffered from non KD. The levels of VEGF in the obtained sera
were measured by using chemoluminoimmunoassay, and those of both groups were compared to
each other.
Results
: The sex ratio of male to female was 1.6 : 1, males were more prone to infection, and
mean age was 2.6¡¾1.6 years old. The levels of VEGF in patients group(143.64¡¾115.38 pg/mL)
were significantly increased as compared with control group(26.55¡¾13.75 pg/mL)(P < 0.05). One
case of acute myocarditis and two cases of left coronary artery dilations occurred in the patient
group, but they all recovered after treatment two months later. Acute phage reactants such as
CRP, ESR were positive and WBC was increased in acute stages of both groups.
Conclusion
: The significant increasing level of serum VEGF in acute febrile stages of KD suggests
that acute vasculitis began in the early stage in all of the patients group, and the measurement
of VEGF can be one of useful method for early diagnosis of vasculitis in KD. This may be
helpful in early IVGG treatment of the condition. |
| Key Words:
Vascular endothelial growth factor, Kawasaki Disease |
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