| Serial Changes of CK, CK-MB after Radiofrequency Catheter
Ablation in Pediatric Patients |
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Se Young Kim, Myung Chul Hyun |
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Department of Pediatrics, College of Medicine, Kyungpook National University, Taegu, Korea |
| 소아에서 전극도자 절제술에 의한 CK, CK-MB의 변화 |
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김세영, 현명철 |
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경북대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: To investigate the degree of myocardial injury incurred by radiofrequency catheter ablation(RFCA), we serially measured CK, CK-MB levels in 24 pediatric paroxysmal supraventricular tachycardia patients undergoing RFCA(male : 12, female : 12, mean age : 10.5 years, mean weight : 37.2 kg).
Methods
: We serially measured blood CK, CK-MB levels, 1 day before RFCA(baseline), 8 hours after RFCA(stage 1), 16 hours after RFCA(stage 2), 24 hours after RFCA. Serial changes of CK, CK-MB levels were compared with baseline levels, age, body weight, number of applied RFCAs, total duration of RFCAs and the site of ablation(left heart ablation, right heart ablation).
Results
: Compared with baseline levels of CK, CK-MB, there were significant increases in CK and CK-MB levels in stage 1(base line : 130.7±54.0 U/L, 1.97±1.74 μg/L, stage 1 : 233.7±165.1, P=0.04, 7.71±7.96, P=0.01, stage 2 : 207.4±131.3, P=0.19, 6.51±8.54, P=0.08, stage 3 : 215.7±151.4, P=0.13, 5.09±4.38, P=0.36). The CK level was found to be elevated(>195 u/L) in 13 patients(54 %), while the CK-MB level was elevated(>5 μg/L) in 12 patients(50%). Comparing left heart ablations(n=11) and right heart ablations(n=13), CK-MB level in stage 1 was significantly increased in left heart ablation(12.29±9.79 μg/L, 3.82±2.48, P=0.02). In right heart ablations, there were significant correlations between the number of applied RFCAs and CK-MB level in stage 1(P=0.02, r=0.65).
Conclusion
: Significant myocardial injury was incurred by RFCA. Considering the small growing heart of pediatric patients, we should take efforts to minimize myocardial injuries. |
| Key Words:
CK, CK-MB, RFCA, Myocardial injury |
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