| Urinary Interleukin-1β Levels in Children with Urinary Tract Infection |
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Kyung Hyo Kim, Young Mi Hong, Gyoung Hee Kim |
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Department of Pediatrics, College of Medicine, Ewha Woman`s University, Seoul, Korea |
| 소아의 요로감염에서 IL-1β의 뇨중 검출에 관한 연구 |
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김경효, 홍영미, 김경희 |
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이화여자대학교 의과대학 소아과학교실 |
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| Abstract |
Purpose
: IL-1β and TNF-α are important mediators of the inflammatory response in serious
bacterial infections. The mucosal and systemic IL-1β and TNF-α responses to urinary tract
infection are analyzed in children with acute urinary tract infection.
Methods
: We studied the levels of these two cytokines in the urine and sera of 21 children at
diagnosis and after treatment with sandwich ELISA method.
Results
: The mean urinary IL-1β level in acute UTI was 3.9pg/ml compared with 1.5pg/ml in
febrile group and 1.6pg/ml in the normal control group(p< 0.05). TNF-α was not elevated in urine
in children with UTI or other groups. These results suggest that bacteriuria is accompanied by
elevated urinary IL-1β levels and that this IL-1β may be locally produced.
Conclusion
: IL-1β is elevated in urine of children with urinary tract infection. This may be due
to a local inflammatory response in the urinary tract. Variation in local cytokine production with
time and the clinical significance of these observations require further study. |
| Key Words:
Urinary tract infection, IL-1β |
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