Study on Anti-neutrophil Cytoplasmic Antibodies in Children with Henoch-Schölein Purpura |
Shin Jong Lee1, Woo Yeong Chung1, Chul Ho Kim1, Jeong Nyeo Lee2 |
1Department of Pediatrics, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea 2Department of Clinical Parthology, Pusan Paik Hospital, College of Medicine, Inje University, Pusan, Korea |
Henoch-Schölein자반증 환아에서 항호중구 세포질 자가항체에 관한 연구 |
이신종1, 정우영1, 김철호1, 이정녀2 |
1인제대학 의과대학 부산 백병원 소아과학교실 2인제대학 의과대학 부산 백병원 임상병리학교실 |
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Abstract |
The presence of IgG, IgA and IgM antineutrophil cytoplasmic antibodies(ANCA) were inves-tigated in 32 children with Henoch-Schölein Purpura(HS purpura), in 14 children with HS pur-pura nephritis who were confirrned by renal biopsy and in 12 control children using flow cytom-etry(FASCan, Beckton-Dickinson, Co, USA) and indirect immunofluorescence technique(Sigma Diagnostics, USA). There were no evidence of IgG, IgA or IgM cytoplasmic ANCA(p-ANCA), and perinuclear ANCA(c-ANCA) in the sera of 32 children. These results suggest that ANCA are not involved in the pathogenesis of vasculitis in HS purpura & HS purpura nephritis. |
Key Words:
Henoch-Schö, lein purpura, Anti-neutrphil cytoplasmic antibodies |
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