| Immunohistochemical Studies on Neuroendocrine Markers in Malignant Neuronal Tumors (Neuroblastoma and Ganglioneuroblastoma) in Children |
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Woo Yeong Chung1, Sun Kyung Lee2 |
1Department of Pediatrics, Pusan Paik Hospital, Inje Medical College, Pusan, Korea
2Department of Pathology, College of Medicine, Pusan National University, ,Korea |
| 소아 악성 신경종에 있어서 신경내분비 표지자에 관한 면역조직화학적 연구 |
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정우영1, 이선경2 |
1인제의대 부산백병원 소아과학교실
2부산의대 병리학교실 |
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| Abstract |
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The authors studied 24 cases of malignant neuronal tumors, 14 neuroblastomas and 10 ganglioneuroblastomas, immunohistochemically, using antibodies to neuroendocrine markers including neuron specific enolase (NSE), somatostatin, chromogranin, β-endorphin, and adrenocorticotrophic hormone (ACTH). The tissue specimens were obtained by biopsy or autopsy at Pusan National University Hopital and Pusan Paik Hospital from 1980 to 1989. The positive reactivity of markers in tumor was compared in observed groups and analyzed statistically.
The results obtained were summarized as follows:
1) The incidence of malignant neuronal tumor, poorly differentiated or occured in extraabdominal sites, was more frequent in younger patients (≤1.5 years) than differentiated or abdominal ones.
2) In 24 cases of malignant neuronal tumor, argentaffin cell was detected in 13 cases (54%) and argyrophil cell in 22 cases (92%). The positivity of argyrophil cell was significantly higher than that of argentaffin cell.
3) Most tumor cells of malignant neuronal tumor had unhomogenous multiple neuroendocrine markers.
4) The positivity of neuroendocrine markers was more frequent in younger patients, or in differentiated tumors than older mpatients of poorly differentiated tumors.
5) Positive rate of neuroendocrine markers was NSE (71%), somatostatin (46%), chromogranin (38%), β-endorphin (29%), and ACTH (25%) in decreased order.
This study concluded that immunostain for two or more markers with high positivity is valuable in differential diagnosis or morphological assessment of malignant neuronal tumor. |
| Key Words:
Malignant neuronal tumors, Neuroendocrine markers, Immunohistochemical study, Children |
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