| Quantification of Human Urinary Growth Hormone and Its Clinical Significance in the Diagnosis of Growth Hormone Deficiency |
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Seung Ryul Lee1, Ho Seong Kim1, Duk Hi Kim1, Chang Mi Kim2 |
1Department of Pediatrics, Yonsei University, College of Medicine, Seoul, Korea
2Endocrine Laboratory, Yonsei University, College of Medicine, Seoul, Korea |
| 성장호르몬 결핍성 왜소증의 진단에서 요중 성장호르몬 측정의 임상적 의의 |
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이승렬1, 김호성1, 김덕희1, 김창미2 |
1연세대학교 의과대학 소아과학교실
2연세대학교 의과대학 내분비연구실 |
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| Abstract |
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Twelve-hour nocturnal urine was collecte in 5 patients diagnosed of having complete GH deficiency, 6 of having partial GH deficiency and 7 persons as normal control group. The GH levels in urine collections were evaluated, and the results are as follows.
1) The GH level of normal control group was 16.76¡¾1.91ng/12hr, 59.00¡¾6.92ng/gCr, 16.24¡¾2.52ng/m2, 0.58¡¾0.12ng/kg.
2) The GH level of complete GH deficiency group was 3.69¡¾1.75ng/12hr, 22.62¡¾10.62ng/gCr, 5.33¡¾2.60ng/m2, 0.22¡¾0.11ng/kg.
3) The GH level of partial GH deficiency group was 5.12¡¾1.13ng/12hr, 25.89¡¾8.48gn/gCr, 6.69¡¾1.61ng/m2, 0.21¡¾0.08ng/kg.
4) There were significant decrease in urinary GH levels in complete and partial GH deficiency groups compared to the normal control group. No significant differences were found between the 2deficient groups and there were many overlapping results.
5) If the GH level from 12 hour nocturnal urine collection is more than 14.2ng/12hr, it is safe to say that the GH deficiency is not present.
In conclusion, the distinction between the complete and partial deficient groups were not possible, but the urinary GH levels of the both groups were clearly decreased compared to the normal control group. Thus, in patients suspecte of short due to the GH deficiency, Measuring GH level is a useful screening test. |
| Key Words:
Growth hormone deficiency, Urinary growth hormone |
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