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Original Article
Allergy
Accuracy of maximal expiratory flow-volume curve curvilinearity and fractional exhaled nitric oxide for detection of children with atopic asthma
Sang Hoo Park, Min Ji Im, Sang-Yong Eom, Youn-Soo Hahn
Clin Exp Pediatr. 2017;60(9):290-295.   Published online September 21, 2017
Purpose

Airway pathology in children with atopic asthma can be reflected by the concave shape of the maximal expiratory flow-volume (MEFV) curve and high fractional exhaled nitric oxide (FeNO) values. We evaluated the capacity of the curvilinearity of the MEFV curve, FeNO, and their combination to distinguish subjects with atopic asthma from healthy individuals.

Methods

FeNO and angle β, which characterizes the general...

House dust mite-specific immunoglobulin E and longitudinal exhaled nitric oxide measurements in children with atopic asthma
Youn Kyung Lee, Sohyoung Yang, Joohyun Park, Heon Kim, Youn-Soo Hahn
Clin Exp Pediatr. 2015;58(3):89-95.   Published online March 20, 2015
Purpose

House dust mite (HDM) has been suggested to be the most important aeroallergen responsible for atopic asthma in Korea. We aimed to investigate that specific IgE antibodies to HDM and other common indoor aeroallergens contribute differently to total serum IgE and show different relationships with longitudinal fractional exhaled nitric oxide (FeNO) measurements in Korean atopic asthmatic patients.

Methods

A total of 193...

Review Article
Measurements of fractional exhaled nitric oxide in pediatric asthma
Youn-Soo Hahn
Clin Exp Pediatr. 2013;56(10):424-430.   Published online October 31, 2013

Exhaled nitric oxide (NO) has been extensively investigated as a noninvasive marker of airway inflammation in asthma. The increased NO expression induced by inflammatory mediators in airways can be monitored easily in exhaled air from asthmatic children. Based on the relationship between the increased NO expression and eosinophilic airway inflammation, fractional exhaled nitric oxide (FeNO) measurements become an important adjunct...

Original Article
Fractional exhaled nitric oxide and forced expiratory flow between 25% and 75% of vital capacity in children with controlled asthma
Ji-Yong Yoon, Sung-Il Woo, Heon Kim, Yong-Han Sun, Youn-Soo Hahn
Clin Exp Pediatr. 2012;55(9):330-336.   Published online September 14, 2012
Purpose

Fractional exhaled nitric oxide (FeNO) and forced expiratory flow between 25% and 75% of vital capacity (FEF25-75) are not included in routine monitoring of asthma control. We observed changes in FeNO level and FEF25-75 after FeNO-based treatment with inhaled corticosteroid (ICS) in children with controlled asthma (CA).

Methods

We recruited 148 children with asthma (age, 8 to 16 years) who had maintained...

Review Article
Pathogenesis and clinical manifestations of juvenile rheumatoid arthritis
Youn-Soo Hahn, Joong-Gon Kim
Clin Exp Pediatr. 2010;53(11):921-930.   Published online November 30, 2010

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic childhood disease; its onset is before 16 years of age and it persists for at least 6 weeks. JRA encompasses a heterogeneous group of diseases that is classified according to 3 major presentations: oligoarthritis, polyarthritis, and systemic onset diseases. These presentations may originate from the same or different causes that involve...

Original Article
Clinical characteristics of acute lower respiratory tract infections due to 13 respiratory viruses detected by multiplex PCR in children
Jeong-Sook Lim, Sung-Il Woo, Hyuk-Il Kwon, Hyuk-Il Kwon, Young-Ki Choi, Youn-Soo Hahn
Clin Exp Pediatr. 2010;53(3):373-379.   Published online March 15, 2010
Purpose : This study was performed to investigate the epidemiologic and clinical features of 13 respiratory viruses in children with acute lower respiratory tract infections (ALRIs). Methods : Nasopharyngeal aspirates were prospectively obtained from 325 children aged 15 years or less from May 2008 to April 2009 and were tested for the presence of 13 respiratory viruses by multiplex real-time-polymerase chain...
Clinical Lecture
Detection and Diagnosis of Primary Immunodeficiency Diseases
Youn-Soo Hahn
Clin Exp Pediatr. 2004;47(5):475-479.   Published online May 15, 2004
Primary immunodeficiency diseases result from innate defects of immune system. As a consequence, recurrent viral, bactrial, fungal, and protozoal infections of varying severity ensue. Although primary immunodeficiency diseases are relatively rare, intensive study of these disorder has expanded our understanding of immunity. Recent progress in immunobiology and genetics has identified the causes of many of the primary immunodeficiency diseases. Diagnosis...
Original Article
Changes of Peripheral IFN-γ-Producing CD4(＋) and CD4(－) Cell Frequencies in Kawasaki Disease
Joung-Min Eom, Heon-Seok Han, Youn-Soo Hahn
Clin Exp Pediatr. 2000;43(10):1350-1355.   Published online October 15, 2000
Purpose : This study was performed to analyze the frequencies of peripheral IFN-γ-producing cells at the single cell level, and to determine concentrations of circulating interferon-γ(IFN-γ) in the acute and subacute phases of Kawasaki disease(KD). Methods : Ten patients with KD were studied and seven healthy children were selected as control subjects. Using immunofluorescent detection of intracellular IFN-γ in CD4(＋) and...
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