Clinical and Experimental Pediatrics

Original Article

Nephrology (Genitourinary)

Variation in clinical usefulness of biomarkers of acute kidney injury in young children undergoing cardiac surgery

Hee Sun Baek, Youngok Lee, Hea Min Jang, Joonyong Cho, Myung Chul Hyun, Yeo Hyang Kim, Su-Kyeong Hwang, Min Hyun Cho

Clin Exp Pediatr. 2020;63(4):151-156. Published online February 5, 2020

Question: Can clinical usefulness of biomarkers of acute kidney injury vary on the clinical circumstances?
Finding: In young children undergoing cardiac surgery, urine KIM-1/Cr level peaked at 24 hours with significant difference from baseline level and was significantly higher at 6 hours in the AKI group. However, urine NGAL/Cr and IL-18/Cr levels showed no specific trend with time for 48 hours after cardiac surgery.
Meaning: Urine KIM-1/Cr concentration could be considered a good biomarker for early AKI prediction after open cardiac surgery in young children.

DOI: https://doi.org/10.3345/cep.2019.00913

Neurology

Efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy

Yuni Yun, Dongsub Kim, Yun-Jeong Lee, Soonhak Kwon, Su-Kyeong Hwang

Clin Exp Pediatr. 2019;62(7):269-273. Published online December 26, 2018

Crossref 17

Purpose: There is limited data on the use of perampanel in children under 12 years of age. We evaluated the efficacy and tolerability of adjunctive perampanel treatment in children under 12 years of age with refractory epilepsy. Methods: This retrospective observational study was performed in Kyungpook National University Hospital from July 2016 to March 2018. A responder was defined as a...

DOI: https://doi.org/10.3345/kjp.2018.06863

Clinical importance of F-waves as a prognostic factor in Guillain-Barré syndrome in children

Eung-Bin Lee, Yun Young Lee, Jae Min Lee, Su Min Son, Su-Kyeong Hwang, Soonhak Kwon, Sae Yoon Kim

Clin Exp Pediatr. 2016;59(6):271-275. Published online June 30, 2016

Crossref 6

Purpose

A limited number of studies have examined the link between F-wave abnormalities and clinical presentation in pediatric Guillain-Barré syndrome (GBS). Therefore, this study examined the importance of F-wave abnormalities as a prognostic factor in pediatric GBS patients.

Methods

The records and electrodiagnostic studies (EDS) of 70 GBS patients were retrospectively evaluated, and divided into 2 groups according to the results of EDS....

DOI: https://doi.org/10.3345/kjp.2016.59.6.271

Review Article

Early-onset epileptic encephalopathies and the diagnostic approach to underlying causes

Su-Kyeong Hwang, Soonhak Kwon

Clin Exp Pediatr. 2015;58(11):407-414. Published online November 22, 2015

Crossref 14

Early-onset epileptic encephalopathies are one of the most severe early onset epilepsies that can lead to progressive psychomotor impairment. These syndromes result from identifiable primary causes, such as structural, neurodegenerative, metabolic, or genetic defects, and an increasing number of novel genetic causes continue to be uncovered. A typical diagnostic approach includes documentation of anamnesis, determination of seizure semiology, electroencephalography, and...

DOI: https://doi.org/10.3345/kjp.2015.58.11.407

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