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Original Article
Cardiology
Prediction of unresponsiveness to second intravenous immunoglobulin treatment in patients with Kawasaki disease refractory to initial treatment
Euri Seo, Jeong Jin Yu, Hyun Ok Jun, Eun Jung Shin, Jae Suk Baek, Young-Hwue Kim, Jae-Kon Ko
Clin Exp Pediatr. 2016;59(10):408-413.   Published online October 17, 2016
Purpose

This study investigated predictors of unresponsiveness to second-line intravenous immunoglobulin (IVIG) treatment for Kawasaki disease (KD).

Methods

This was a single-center analysis of the medical records of 588 patients with KD who had been admitted to Asan Medical Center between 2006 and 2014. Related clinical and laboratory data were analyzed by univariate and multivariate logistic regression analyses.

Results

Eighty (13.6%) of the 588 patients...

Review Article
Genetic risk factors associated with respiratory distress syndrome
Heui Seung Jo
Clin Exp Pediatr. 2014;57(4):157-163.   Published online April 30, 2014

Respiratory distress syndrome (RDS) among preterm infants is typically due to a quantitative deficiency of pulmonary surfactant. Aside from the degree of prematurity, diverse environmental and genetic factors can affect the development of RDS. The variance of the risk of RDS in various races/ethnicities or monozygotic/dizygotic twins has suggested genetic influences on this disorder. So far, several specific mutations in...

Original Article
The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
Ho Keun Yi, Dong Jin Hwang, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(8):884-891.   Published online August 15, 2004
Purpose : PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In this study, we examined to evaluate the new function of anti-tumor effects of PTEN/MMAC1 through the regulation of the IGFs-IGFBPs in gastric cancer cells. Methods : PTEN/MMAC1 was expressed in...
Alteration of Biochemical Profiles after High-Dose Intravenous Immunoglobulin Administration in Kawasaki Disease
Ji-Won Lee, Kyung-Yil Lee
Clin Exp Pediatr. 2003;46(8):817-820.   Published online August 15, 2003
Purpose : Intravenous immunoglobulin(IVIG) has been used as an immunomodulatory treatment for several immune-mediated diseases. The early effect of high-dose IVIG on biochemical profiles including lipids and proteins was evaluated in patients with Kawasaki disease(KD). Methods : Twelve children with KD(nine boys) were treated with IVIG of 2 g/kg over 12 hours. Serial sera were collected from the patients four times...
A Study on Serum Lipids and Lipoproteins in Acute Viral Hepatitis in Children.
Kyu Hyoung Han, Chang Soo Ra
Clin Exp Pediatr. 1985;28(7):642-652.   Published online July 31, 1985
Most of the lipids in serum are transported in the from of lipoproteins. A major portion of these lipoproteins is formed in the liver. The determination of serum lipoprotein patterns is a better index of liver abnormalities than determination of lipids alone. The authors determined serum lipid concentration and the patterns of serum lipoproteins in 40 cases of acute viral...
Developmental Changes of Membrane Proteins from Human Erythrocytes.
Chan Uhng Joo, Hyun Suk Lee, Jung Soo Kim, Kyu Cha Kim, Hyung Rho Kim
Clin Exp Pediatr. 1982;25(6):541-546.   Published online June 30, 1982
To investigate the developmental changes of human erythrocytes, adult and fetal erythrocyte membranes prepared from adult and cord blood were analyzed in regard to their proteins, glycoproteins, enzyme activities and glucose transport systems. 1. Adult and fetal erythrocyte membranes appeared to have the same major proteins and gl-ycoproteins in the electrophoretic pattern. 2. ATPase activity in adult erythrocyte membranes was...
An Electrophoretic Study of Serum and Cerebrospinal Fluid Proteins in Newborn Infants.
Hyeon Soo Park, Woo Gill Lee, Chong Moo Park
Clin Exp Pediatr. 1981;24(11):1021-1027.   Published online November 15, 1981
There are many diseases that have a characteristic protein electrophoretic patterns of serum and cerebrospinal fluid. The protein electrophoretic study of serum and cerebrospinal fluid has been used clinically for the diagnosis of such diseases. There are very few studies and references on this subject to available in Korea. Therefore authors studied the protein electrophoretic patterns of serum and cerebrospinal...
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