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Original Article
Growth Status and Levels of Growth Factors in Children with Insulin-dependent Diabetes Mellitus
So Chung Chung, Duk Hee Kim
Clin Exp Pediatr. 1998;41(8):1102-1110.   Published online August 15, 1998
Purpose : It is well known that the linear growth velocity in children with insulin-dependent diabetes mellitus(type 1 DM) is closely related to metabolic control and onset age of the disease. Many studies have demonstrated growth impairment in children with type 1 DM, regardless of the degree of metabolic control, whereas other studies have found no growth retardation. Therefore, we...
Case Report
A Case of Mauriac's syndrome
Se Young Kim, Choong Ho Shin, Il Soo Ha, Hae Il Cheong, Sei Won Yang, Yong Choi, Hyung Ro Moon
Clin Exp Pediatr. 1996;39(7):1020-1024.   Published online July 15, 1996
Mauriac's syndrome was described in the 1920s, as a triad of poorly controlled insulin dependent diabetes mellitus, profound growth retardation, and hepatomgaly. Following the wide availability of insulin and intensification of diabetic control, this entity has become quite rare. A 9-year-old female child was transferred to pediatric OPD of SNUCH because of hyperglycemia, short stature, and visual disturbance. Five years prior to admission, she...
Original Article
Sex Hormone Binding Globulin Levels in Children with Insulin Dependent Diabetes Mellitus
Duk Hi Kim, Mi Jung Park, Ho Sung Kim
Clin Exp Pediatr. 1995;38(7):963-969.   Published online July 15, 1995
Purpose : Sex hormone binding globulin(SHBG) is produced in liver and binds to testostero-ne and estradiol. Plasma SHBG levels are increased by estrogen and thyrotoxicosis and decreased by testostrone, insulin, growth hormone, prolactin, obesity and noninsulin dependent diabetes mellitus. SHBG levels in patients with NIDDM is known to be higher than normal, but SHBG levels in children with IDDM is controversial....
Clinical Study on Insulin Dependent Diabetes mellitus
Seog Beom Cho, Kwang Rae Lee, Chang Beom Shin, Oh Kyung Lee, Chong Duk Kim, Oh Kyung Lee
Clin Exp Pediatr. 1995;38(6):827-834.   Published online June 15, 1995
Purpose : Insulin dependet diabetes mellitus(IDDM) is a rare disease in children, but it will progress rapidly and falls into a diabetic ketoacidosis or coma. Unfortunately, the characteristics and prevalence rate of children with IDDM are not well known in Korea. With a view to recognizing its importance, we studied clinical course of IDDM patients in Chonbuk province, Korea. Methods : From...
The Growth Hormone-Binding Proteins in Human Serum: Partial characterization and Regulation
Ji Young Suh, Bu Hun Lee, Jeh Hoon Shin, Hang Lee, Seong Ryul Jang
Clin Exp Pediatr. 1994;37(10):1427-1436.   Published online October 15, 1994
We assessed abotu growth homone binding proteins(GHP|BP) activity which was measured eluted biotin GH fraction with alkaline phosphatase-streptavidine in children with insulin dependent diabetes mellitus(IDDM), short stature due to growth hormone deficiency(GHD), chronic renal failure, short stature due to nutritional deficiency. Hypothyroidism, and noraml control groups using high pressure liquid chromatography protein pak 300 sw column. The following results are observed: 1)...
The Findings of 2D and M-mode Echocardiography in Young Insulin-Dependent Diabetes Mellitus.
Byoung Rei Cho, Jae Wook Ko, Young Jin Hong, Don Hee Ahn, Keun Chan Sohn
Clin Exp Pediatr. 1990;33(1):88-93.   Published online January 31, 1990
Twenty-one children and young adults with Insulin-dependent diatetes mellitus and 23 control underwent 2D and M-mode echocardiography. Following results were obtained: 1) LVESD, LVEDD, EF, FS, LAD/AOD ratio, Dm of IVS and Dm of PLVWT were not significantly different in diabetics compared to control subjects. 2) In IDDM PEP was slightly increased and LVET was slightly decreased, but there was not statistical significance between the two groups. But...
The Effect of Pertussive Vaccine & Cyclosporin on Streptozotocin Induced Diabetic Rats.
Duk Hi Kim
Clin Exp Pediatr. 1988;31(7):914-923.   Published online July 31, 1988
The injection of streptozotocin (STZ) at higher dose (60 mg/kg) to young male rats produce direct beta cell destruction and lead to insulin dependent diabetes (IDD). In contrast, the injection of multiple smaller dose of STZ (40 mg/kg/d for 5 days) produce IDD, which resembles type 1 diabetes in man. The protective effect of pertussis vaccine (PV) & cyclosporin (CA) against the develoment...
The Effects of Cyclosporin in Treatment of Insulin Dependent Diabetes Mellitus.
Duk Hi Kim
Clin Exp Pediatr. 1985;28(6):564-569.   Published online June 30, 1985
A 2 year 10 month old girl with 6 weeks duration and 13 year 4 month old boy with 8 weeks duration were given cyclosporin for 68 days. Therapy was initiated orally at the dosage of 10 mg per kg of body per day. Blood glucose, C-peptide, cyclosporin, creatinin, BUN and transaminase were checked regularly. Cyclosporin treatment allowed two patients to...
A Clinical Study on Insulin Dependent Diabetes Mellitus.
H S Kim, Y K Suh, T W Paik, Y D Kwon, C M Kang
Clin Exp Pediatr. 1984;27(9):903-911.   Published online September 30, 1984
The authors studied twelve cases of insulin dependent diabetes mellitus who were admitted to Pediatric Department of Keimyung University, Dong San Hospital from February 1975 to January 1983. Disease was developed after puberty in eight cases and effected both sexes equally and had tendency, prevalent in winter season. There was no significant family history except one case who had diabetic...
Case Report
Three Cases of Insulin Dependent Diabetes Mellitus in Children.
Tae Hoon Lee, Sang Chul Park, Chang Hwi Kim, Sang Man Shin, Sang Jhoo Lee
Clin Exp Pediatr. 1983;26(3):285-289.   Published online March 31, 1983
We experienced three cases of Insulin Dependent Diabetes Mellitus, which revealed fullfilling- all characteristics of clinical 技 laboratory finding during recent 3 years. Two diabetic children among three patients had developed diabetic ketoacidosis. The one of the two cases, 14 aged girl complained of dyspnea & severe emaciation. The another case, 11 year and 2 month-old boy who had cataract complained of severe epigastric pain,...
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