Clinical and Experimental Pediatrics

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Original Article

Efficacy of imatinib mesylate-based front-line therapy in pediatric chronic myelogenous leukemia

Hyun Jin Oh, Mun Sung Cho, Jae Wook Lee, Pil-Sang Jang, Nack-Gyun Chung, Bin Cho, Hack-Ki Kim

Clin Exp Pediatr. 2013;56(8):343-350. Published online August 27, 2013

Crossref 5

Purpose

Despite the established role of imatinib (IM) in chronic myelogenous leukemia (CML) in adults, there are few reports on its efficacy in children. In this study, we compared the outcomes of children with CML before and after the advent of IM-based treatment.

Methods

The study cohort consisted of 52 patients treated for CML at the Department of Pediatrics, The Catholic University of...

DOI: https://doi.org/10.3345/kjp.2013.56.8.343

Medical Lecture Course

Regulatory T Cells and Allogeneic Transplantation

Dae Chul Jeong

Clin Exp Pediatr. 2004;47(9):919-925. Published online September 15, 2004

Allogeneic organ or hematopoietic stem cell transplantation(HSCT) is the treatment of choice for end-stage organ diseases or various hematologic disorders. The induction of alloantigen specific T cell tolerance and its maintenance are critical for preventing immune responses, including graft rejection or graft-versus-host disease(GVHD) in allogeneic transplantation. CD4＋ T cells are classified as immune functions : Th1 CD4＋ cells for cellular...

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