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Original Article
Bystander Effect of HSV-TK/GCV Gene Therapy in Murine Neuroblastoma
Eun Jung Shim, Se Ryoung Kim, Eun Hae Park, Hyun Sang Cho, Jae Kook Cha, Hae Ran Lee
Clin Exp Pediatr. 2001;44(11):1249-1253.   Published online November 15, 2001
Purpose : To demonstrate the bystander effect in murine neuroblastoma model which transduced with HSV-TK gene in vitro and in vivo. Methods : The LNC/TK vector was transfered in vitro into the neuro-2a cells, murine neuroblastoma cell line. Variable mixed populations of neuro-2a cells consisting of HSV-TK＋ or HSV-TK－ were plated into culture plates and treated with GCV for...
Case Report
A Case of Encephalopathy Presented with Motor Aphasia and Quadriplegia Following Intrathecal Methotrexate
Seon Woo Lee, Eun Hye Park, Hyun-Sang Cho, Jae Kook Cha, Hae Ran Lee
Clin Exp Pediatr. 2001;44(9):1066-1069.   Published online September 15, 2001
Intrathecal administration of methotrexate(IT-MTX) has constituted the standard approach to prophylaxis and treatment of central nevous system(CNS) leukemia. We experienced a quadriplegia and motor aphasia in a 14-year-old boy following repeated IT-MTX for the prophylaxis of meningeal leukemia. He was diagnosed as ALL without CNS involvement and treated by CCG- 1882 protocol. IT-MTX was administered for CNS prophylaxis. The patient began complaining of urinary incontinence,...
A Case of T-cell Acute Lymphoblastic Leukemia presented with Spontaneous Tumor Lysis Syndrome and Superior Vena Cava Syndrome
Eun Jung Shim, Hyun-Sang Cho, Jae Kook Cha, Jae Kook Cha, Chong Young Park
Clin Exp Pediatr. 2000;43(7):974-977.   Published online July 15, 2000
Acute spontaneous tumor lysis syndrome is a condition resulting from the rapid release of cellular breakdown products into the circulation due to massive cytolysis occurring before start of treatment. It occurs most often in Burkitt' s lymphoma and T-cell ALL, both of which have been well described, following cytotoxic chemotherpy and other single agent administrations. However, only a handful of spontaneous acute tumor lysis...
A Case of Septic Pulmonary Emboli in Ventricular Septal Defect
Keum Bong Jee, Jae Kook Cha, Kon Hee Lee, Kwan Seop Lee
Clin Exp Pediatr. 1999;42(2):279-283.   Published online February 15, 1999
Septic pulmonary emboli(SPE) is derived from a variety of sources, including infected heart valves, peripheral sites of septic thrombophlebitis and infected venous catheters or pacemaker wires. In adult intravenous drug users, the most common cause of septic emboli is tricuspid valve endocarditis, but infective endocarditis in the non-complicated ventricular septal defect is a relatively rare condition in infants and...
Three Cases of Acute Focal Bacterial Nephritis
Yeon Soo Lim, Jae Kook Cha, Kon Hee Lee, Kwan Seop Le
Clin Exp Pediatr. 1999;42(1):138-142.   Published online January 15, 1999
Acute focal bacterial nephritis(AFBN) is an unusual form of localized renal infection, which has various imaging findings and should be distinguished from abscess or other renal masses. Clinical symptoms are similar to other urinary tract infections but the diagnosis needs a CT or sonographic confirmation. Treatment, which is nonoperative, consists of intensive antibiotic therapy. We report three cases of AFBN...
Original Article
A Clinical Study of Histiocytosis Syndrome
Jong Jin Kim, Jae Kook Cha, Kon Hee Lee, Jong Young Park
Clin Exp Pediatr. 1998;41(11):1575-1582.   Published online November 15, 1998
Case Report
A Case of Ectopic Pancreas with Malrotation
Il Song Kang, Kil Soo Chung, Jae Kook Cha, Kon Hee Lee, Kwan Seop Lee, Byung Chun Kim, Eun Sook Nam
Clin Exp Pediatr. 1998;41(10):1438-1441.   Published online October 15, 1998
Ectopic pancreas is defined as pancreatic tissue lacking anatomical and vascular continuity with the main body of the pancreas. Common symptoms are epigastric pain, hemorrhage, chest pain, weight loss, nausea and vomiting. A 2-month-old male patient was hospitalized because of continuous bile stained vomiting for 2 days. Abdominal ultrasonography and colon study showed malrotation of the intestine. Surgical exploration revealed...
Original Article
Comparison of Antimicrobial Susceptibility of Nosocomial and Community-Acquired Pathogens in Children of Medium-Sized Hospital
Kil Soo Joung, Jae Kook Cha, Kon Hee Lee, Hye Sun Yoon, Wonkeun Song
Clin Exp Pediatr. 1997;40(11):1537-1543.   Published online November 15, 1997
Purpose : We evaluated the identification and antimicrobial susceptibility patterns of nosocomial and community-acquired pathogens in children of the medium-sized hospital. Methods : The 357 bacterial strains isolated from Pediatric department of Dongsan Sacred Heart Hospital were examined the species identification and antimicrobial susceptibility test during the period of March to October 1996. Results : Fifty three strains(15%) of 357 strains were nosocomial pathogens. A...
Case Report
A Case of Congenital Acute Megakaryoblastic Leukemia with Down Syndrome
Nan Yee Kye, Kon Hee Lee, Jae Kook Cha, Hye Sun Yoon, Won Keun Song
Clin Exp Pediatr. 1997;40(4):578-583.   Published online April 15, 1997
We experienced a case of congenital acute megakaryoblastic leukemia with Down syndrome. The patient was admitted due to characteristic facial figure of Down syndrome and abdominal distension. Acute megakaryoblastic leukemia was diagnosed with abundant megakaryoblast in peripheral blood smear, severe myelofibrosis in bone marrow biopsy and positive platelet glycoprotein Ⅲa receptor. On third hospital day, the patient expired due to DIC...