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Original Article
Clinical disease characteristics according to karyotype in Turner syndrome
Chae Young Yeo, Chan Jong Kim, Young Jong Woo, Dae Yeol Lee, Min Sun Kim, Eun Young Kim, Jong Duck Kim
Clin Exp Pediatr. 2010;53(2):158-162.   Published online February 15, 2010
Purpose : Turner syndrome (TS) is a disorder in which various anomalies can be accompanied, especially cardiovascular, renal, thyroid and auditory problems. The aim of this study is to identify the incidence of these disorders in patients with TS according to karyotype. Methods : We reviewed medical records of 90 patients with TS diagnosed by chromosomal analysis in 4 hospitals...
Iron chelating agent, deferoxamine, induced apoptosis in Saos-2 osteosarcoma cancer cells
Eun Hye Park, Hyo Jung Lee, Soo Yeon Lee, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2009;52(2):213-219.   Published online February 15, 2009
Purpose : Iron is a critical nutritional element that is essential for a variety of important biological processes, including cell growth and differentiation, electron transfer reactions, and oxygen transport, activation, and detoxification. Iron is also required for neoplastic cell growth due to its catalytic effects on the formation of hydroxyl radicals, suppression of host defense cell activities, and promotion of...
The anti-tumor mechanisms of p53 through the regulation of expression and glycosylation of insulin-like growth factor binding protein-3
Sun Young Kim, Se Rim Kim, Jung Chang Lee, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2006;49(4):431-438.   Published online April 15, 2006
목 적 : 새로운 암억제 유전자로 알려진 IGFBP-3의 주요 기능은 IGF-I과 IGF-II와 결합을 하여 IGF의 기능을 조절하는 IGF dependent mechanism과 IGFBP-3 자체가 IGF와 결합과는 무관하게 세포의 apoptosis를 유도하는 IGF independent mechanism이 보고되었다. 암억제 유전자 p53의 대표적인 항암기전의 하나는 직접 IGFBP-3의 발현을 증가시키며, 발현된 IGFBP-3는 암세포의 apoptosis를 유도시킨다. IGFBP-3의 항암작용은 보고되었지만, IGFBP-3의 변역 후 변형에 의한 항암기전은 전혀 밝혀져 있지 않다....
The Tumor Suppressor Function of PTEN/MMAC1 through the Regulation of IGFs and IGFBPs
Ho Keun Yi, Dong Jin Hwang, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(8):884-891.   Published online August 15, 2004
Purpose : PTEN/MMAC1, a novel tumor suppressor gene, is mutated in a variety of advanced and metastatic cancers. It acts as a phosphatase, and thereby, regulates the PI-3 kinase/Akt pathway. In this study, we examined to evaluate the new function of anti-tumor effects of PTEN/MMAC1 through the regulation of the IGFs-IGFBPs in gastric cancer cells. Methods : PTEN/MMAC1 was expressed in...
Diagnostic Approach of Wiskott-Aldrich Syndrome
Dong Jin Hwang, Jun Won Yang, Sun Young Kim, Ho Keun Yi, Dae Yeol Lee, Pyoung Han Hwang
Clin Exp Pediatr. 2004;47(7):726-734.   Published online July 15, 2004
Objective : A probable diagnosis of Wiskott-Aldrich syndrome(WAS) should be considered in any boy presenting with unusual bleeding, congenital thrombocytopenia and small platelets. The definitive diagnosis of WAS is usually made by the detection of WASP gene mutation or a decrease or absence of the WAS protein(WASP) in blood cells using molecular genetic analysis. However, these methods are too time-consuming...
Apoptotic Pathway Induced by Dominant Negative ATM Gene in CT-26 Colon Cancer Cells
Jung Chang Lee, Ho Keun Yi, Sun Young Kim, Dae Yeol Lee, Pyoung Han Hwang, Jin Woo Park
Clin Exp Pediatr. 2003;46(7):679-686.   Published online July 15, 2003
Purpose : Ataxia telangiectasia mutated(ATM) is involved in DNA damage responses at different cell cycle checkpoints, and signalling pathways associated with regulation of apoptosis in response to ionizing radiation(IR). However, the signaling pathway that underlies IR-induced apoptosis in ATM cells has remained unknown. The purpose of this study was, therefore, to investigate the apoptotic pathway that underlies IR-induced apoptosis in...
Novel Gap Junction Molecules, Connexin 37, Enhances the Bystander Effect in HSVtk/GCV Gene Therapy
Sun Young Kim, Ho Keun Yi, Jung Chang Lee, Dong Jin Hwang, Pyoung Han Hwang, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 2003;46(6):541-547.   Published online June 15, 2003
Purpose : Gap junction intercellular communication(GJIC) is an important mechanism of the bystander effect in herpes simplex thymidine kinase/ganciclovir(HSVtk/GCV) gene therapy Therefore, we attempted to enhance the bystander effect in vitro by exogenous overexpressing connexin 37(Cx37) in cells to increase GJIC. Methods : NIH3T3 cells were transfected with the Cx37 and HSVtk gene or the HSVtk gene alone by the calcium...
Anti-angiogenesis and Anti-metastasis Characteristics of the Novel Tumor Suppressor Gene PTEN
Pyoung Han Hwang, Ho Keun Yi, Myoung Hee Han, Dae Yeol Lee, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2001;44(6):654-663.   Published online June 15, 2001
Purpose : The tumor suppressor gene PTEN/MMAC1 is mutated in a variety of advanced and metastatic cancers, strongly suggesting that PTEN/MMAC1 alterations may be involved in tumor progression and the formation of metastases. However, the roles of PTEN in tumor growth and metastasis and its functional mechanisms are not fully understood. We evaluated the tumor suppressor function of PTEN/MMAC1 gene...
Studies on Functional Differentiation of Small Intestinal Epithelial Cells
Ho Keun Yi, Su Mi Oh, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2001;44(5):523-532.   Published online May 15, 2001
Purpose : We investigated compounds from food sources given to children that may induce the differentiation of small intestinal epithelial cells in order to signal pathways that induce the proliferation and differentiation of small intestinal epithelial cells. Methods : We analyzed small intestinal epithelial cell differentiation using in vitro IEC-6 cells model. The growth curve of IEC-6 cells was obtained...
Effectiveness of Preoperative Transcatheter Arterial Chemoembolization in Hepatoblastoma
Pyoung Han Hwang, Dae Sun Jo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(8):1098-1105.   Published online August 15, 2000
Purpose : To evaluate the effectiveness of transcatheter arterial chemoembolization(TACE) as a preoperative treatment for initially unresectable hepatoblastomas. Methods : From January 1995 to July 1999, we identified two boys and three girls(age range : 5- 27 months; mean age : 12 months) with pathologically-confirmed hepatoblastoma. To assess response to treatment, we utilized an identical TACE procedure for all the patients....
Induction of Apoptosis of Ewing`s Sarcoma Cells by Regulating Fusion Protein Expression
Ho Keun Yi, Ran Ju Kim, Dae Yeol Lee, Jung Soo Kim, Pyoung Han Hwang
Clin Exp Pediatr. 2000;43(7):942-951.   Published online July 15, 2000
Purpose : Fusion genes(EWS-Fli-1 and EWS-erg ) function as transcription activators and are essential for maintaining tumorigenic properties in Ewing`s sarcoma cells. Several reports have noted that Ets family transcription factors bind with CBP(CREB binding protein) in vitro. To understand the interaction of fusion proteins and CBP, we studied the CBP protein in TC135 cells expressing the EWS-Fli-1 gene. We...
Profile of Insulin, Growth Hormone and Insulin-like Growth Factors in Human Cord Blood According to Birth Weight
Hye Young Kim, Dae Yeol Lee, Soo Chul Cho
Clin Exp Pediatr. 1998;41(11):1484-1490.   Published online November 15, 1998
Purpose : Insulin-like growth factors(IGFs) are mitogenic peptides that are essential for fetal and maternal tissue growth during pregnancy. They circulate primarily with serum IGF-binding protein(IGFBP) which regulates the availability of IGFs to their specific target tissue. This study was performed to examine the relationships between birth weight and IGFs, insulin and growth hormone in the sera of cord blood...
Case Report
A Case of the Renal Artery Aneurysm Associated with the Dysplastic Kidney
Tae Hee Park, Soo Hee Chang, Young Min Han, Soo Chul Cho, Dae Yeol Lee
Clin Exp Pediatr. 1995;38(11):1571-1576.   Published online November 15, 1995
Multicystic dysplastic kidney is the most frequent cause of abdominal mass in the neonate. It is frequently associated with contralateral genitourinary tract abnormalities and the most common abnormality is vesicoureteral reflux. Renal artery aneurysm is very rare in the children. Furthermore the case associated with the renal artery aneurysm has not been reported yet. We experienced a case of the left...
A Case Report of Acrorenal Syndrome
Soo Hee Chang, Jo Seph Choi, Soo Chul Cho, Dae Yeol Lee
Clin Exp Pediatr. 1995;38(8):1151-1154.   Published online August 15, 1995
Acrorenal syndrome is congenital anomaly of the limbs and urinary tract of unknown etiology. Acral malformations consist of varying combinations of oligodactyly, ectrodactyly, syndactyly, brachydactyly, polydactyly, and carpal, tarsal, or metatarsal fusions of the hands and feet. Urinary tract abnormalities include unilateral renal agenesis and duplication of the collecting system. The condition is a polytopic developmental field defect(acrorenal field) and...
Hutchinson-Gilford Progeria Syndrome
Moon Whan Lee, Byoung Geun Lee, Pyung Han Hwang, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1992;35(7):971-977.   Published online July 15, 1992
Hutchinson-Gilford Progeria Syndrome is an extremely rare condition that was initially reported by Jonathan Hutchinson in 1886 and further described by Hastings Gilford in 1904. Clinical manifestations are evident by the first or second year of life with the physical characteris-tics of the elderly. Progeric patients ordinarily develop atherosclerosis and die of cardiac or cerebral vascular disease between 7 and 27...
A case of Trisomy 8 mosaicism
Hong-Ro Lee, Byung-Geun Lee, Soo-Chul Cho, Dae Yeol Lee, Jung Soo Kim, So Ja Jin
Clin Exp Pediatr. 1992;35(6):845-850.   Published online June 15, 1992
This paper presents clinical manifestations and result of cytogenetic examination of a patient with trisomy 8 mosaicism syndrome. Characteristic features include hypertelolism, deep set eyes, anteverted nose, narrow pelves, hypospadia, camptodactyly and deep skin crease and furrows. Karyotyping and chromosomal analysis revealed 47 XY, + 8 mosaicism. A brief review of literature was presented.
Original Article
A Clinicopathological Study on Renal Biopsies in Children
Hun Choi, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1992;35(6):744-752.   Published online June 15, 1992
A clinical and histopathologic study was made oin 50 cases of renal biopies in children who admitted to chon buk national university hospital from December 1987 to July 1990. The result were as follows : 1) Among 50 cases, 35 cases were male and 15 cases female. The sex ratio of male to female was 2.3 : 1. The age distribution was...
A case of xanthogranulomatous pyelonephritis.
Jin Oh Kim, Soo Young Cho, Joo Hyung Kim, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1991;34(3):413-418.   Published online March 31, 1991
Xanthogranulomatous pyelonephritis is an atypical form of severe chronic renal parenchymal infection, which can be mistaken for tumor or other inflammatory renal disease due to similar clinical manifestations. This disease was classified into three stages based on the extent of involvement of renal and adjacent tissue by the xanthogranulomatous process. In stage I (nephric), the characteristic xantho- granulomatous inflammatory process is confined to the kidney. The...
Prevalence of asymptomatic hematuria, proteinemia and glucosuria in primary school children in Chonju area.
Jin Oh Kim, Joseph Choi, Soo Cheol Cho, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1991;34(2):223-229.   Published online February 28, 1991
The present study was performed to define the prevalene of asymptomatic hematuria, proteinuria,and glucosuria. A total of 5011 primary school children in Chonju city were examined with test strip urinalysis during the period of one month from June to July 1989. Test strip (Hema-Combistix) was used in this examination. The results were as. follows: 1) Prevalence of hematuria, proteinuria and glucosuria were 0.8% (40 children), 0.78%...
Changes of Plasma Atrial Natriuretic Peptide and Antidiuretic Hormone in Congenital Heart Disease.
Sun Jun Kim, Jong San Lee, Chan Uhng Joo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1989;32(8):1106-1116.   Published online August 31, 1989
Human atrial myocytes secrete atrial natriuretic peptides (ANP) into the plasma, which causes rapid and marked natriuresis, diuresis and vasorelaxation. The releases of renin, aldosterone, and antidiuretic hormone are inhibited by ANP in vivo and in vitro experiments. Various atrial natriur- etic peptides were isolated and synthesized. Plasma ANP concentrations usually elevated in conges- tive heart failure, chronic renal failure, pulmonary arterial hypertension, tachyarrhythmia,...
A Case of Pulmonary Squestration.
Byung Sook Park, Jin Oh Kim, Beyong Sang Choi, Chan Uhng Joo, Dae Yeol Lee
Clin Exp Pediatr. 1988;31(10):1390-1393.   Published online October 31, 1988
Pulmonary sequestration is an uncommon congenital malformation charcterized by the presence of nonfunctioning lung tissue which usually has no communciation with the normal bronchial tree and which receives it's blood supply from an anomalous systemic artery instead of pulmonary arterial branch. We have experienced a case of pulmonary sequestration. The patient was 5 10/12 years old girl with the complaint of fever, cough, Chest films...
Effect of Adriamycin on Lipid Metabolismin Rats.
Chang Beom Shin, Sun Jun Kim, Chan Unng Joo, Dae Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 1988;31(9):1133-1138.   Published online September 30, 1988
This experiment was carried out to investigate the disturbance of lipid metabolism after long-term administration of adriamycin in rats (2.5 mg/kg/week for 5 weeks, S.C.). Changes of Serum lipids, GOT, GPT, LDH, albumin, BUN, and creatinine were investigated after administration of adriamycin. Clinical findings of congestive heart failure and changes of body weight were also observed during experiment. The results were as follows; 1) Serum triglyceride, total cholesterol,...
Case Report
A Clinical Experience of Continuous Ambulatory Peritoneal Dialysis in Child.
Heon Seob Song, Byung Sook Park, Kyung Jin Shin, Beyong Sang Choi, Dae Yeol Lee
Clin Exp Pediatr. 1987;30(5):560-568.   Published online May 31, 1987
Although it is generally accepted that renal transplantation provides the optimal therapy for children with endstage renal disease (ESRD), there is still uncertainty regarding the most suitable form of dialysis for children awaiting transplantation or for chronic therapy in children in whom transplantation is either not possible or unsuccessful. The therapeutic results of chronic maintenance hemodialysis in children with ESRD have been unsatisfactory because...
Original Article
Studies on the Changes of Serum Osmolality Electrolytes, Digoxin-like Substance and Plasma Renin Activity Following Angiocardiography using Hypertonic Contrast Media.
Heon Seob Song, Hyeong Won Shin, Chan Uhung Joo, Dae Yeol Lee, Jin Gon Jun
Clin Exp Pediatr. 1987;30(4):398-405.   Published online April 30, 1987
Angiocardiography and cineangiocardiography have been employed with increasing frequency for the diagnosis of cardiovascular diseases. These commonplace technics of cardiovascular radiology depend upon the rapid injection of hypertonic contrast media into the heart or central circulation. In order to study the effects of concentrated radiopaque materials(Conray®, 1382 mOsm/L, 1-2 ml/ kg) on hemodynamic consequences, the changes of serum osmolality, sodium, potassium, chloride, digoxin-like substance and...
Endogenous Digoxin-like Substance in Neonatal Serum, Pregnant Women and Placental Extracts.
Heon Seob Song, In Soo Choi, Dae Yeol Lee, Jung Soo Kim, Chang Beom Shin, Yong Bae Shin
Clin Exp Pediatr. 1986;29(9):940-947.   Published online September 30, 1986
To digoxin-like substance, the authers tried to confirm the presence of this substance in cord blood, sera from premature and full-term infants, third trimester pregnant women not receiving digoxin, and placental extracts, and to investigate the origin and potential physiologic role of DLS, endogenous Na+, K+-ATPase inhibitor in relation to renin activity. The results were as follows; 1) Cord sera DLS...
Case Report
Pulmonary Sequestration intralobar Type.
San Ho Kim, Jong Bum Kim, Dae Yeol Lee, Jong Jin Won
Clin Exp Pediatr. 1983;26(9):899-904.   Published online September 30, 1983
Pulmonaary sequestration is a relatively uncommon anomaly that usually requires arteriography for definitive diagnosis. We recently experienced a case in which the diagnosis of intraloar pulmonary sequestration was confirmed by aortogram & surgery. The patient was 9 years old female with the chief complaint of coughing, fever, sweating, and myalgia. The sequestration was resected by lobectomy. The authors report a case of...
Original Article
Effects of Arginine Vasopressin on Renal Function in the Rabbit.
Dae Yeol Lee, Sun Taik Rhim, Jung Soo Kim, Kyu Cha Kim, Kyung Woo Cho
Clin Exp Pediatr. 1981;24(7):638-644.   Published online July 15, 1981
It has long been known that Vasopressin could increase the urinary sodium and chloride excretion. The exact mechanism and site of action, however, have not yet been explained. Experiments were performed whether the renal effects were the same in both cortical and juxtamedullary nephron in decorticated kiddney model. Heat-decortication was car ried out in the left kidney immersed in water...
Case Report
Nursing Bottle Caries.
Dae Yeol Lee, Soo Chul Cho, Jung Soo Kim, Kyu Cha Kim
Clin Exp Pediatr. 1980;23(7):582-585.   Published online July 15, 1980
Feeding habits and sugar contents contents affect dental health and ultimately the total health of young chidren. Nursing bottle caries, nursing botte syndreme, bottle-propping caries are synonymous term for a devastaing condition that may render young children dental cripples. Typically, the primary maxillary incisors are affected most severely and mandibular incisors are seldom involved. We report 4 cases of nursing...